Iranian Journal of Pediatrics

Published by: Kowsar

Comparative Analysis of Iron Metabolism and Its Adjustment Changes at Cancer Patients in Childhood

Gulsan Yavuz 1 , Emel Unal 1 , Nurdan Tacyildiz 1 , S.Kenan Kose 2 , Hafize Gokce 1 , Zulfukar Gordu 1 , Esra Pekpak 1 , Basak Aksoy 1 , Eda Ilarslan 3 , Fatih Gunay 3 and Handan Dincaslan 1 , *
Authors Information
1 Department of Pediatric Hematology-Oncology, Ankara University School of Medicine, Ankara, Turkey
2 Department of Biostatistic, Ankara University School of Medicine, Ankara, Turkey
3 Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey
Article information
  • Iranian Journal of Pediatrics: October 2017, 27 (5); e10092
  • Published Online: October 22, 2017
  • Article Type: Research Article
  • Received: December 19, 2016
  • Revised: July 25, 2017
  • Accepted: September 2, 2017
  • DOI: 10.5812/ijp.10092

To Cite: Yavuz G, Unal E, Tacyildiz N, Kose S, Gokce H, et al. Comparative Analysis of Iron Metabolism and Its Adjustment Changes at Cancer Patients in Childhood, Iran J Pediatr. 2017 ; 27(5):e10092. doi: 10.5812/ijp.10092.

Copyright © 2017, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Torti SV, Torti FM. Iron and cancer: more ore to be mined. Nat Rev Cancer. 2013; 13(5): 342-55[DOI][PubMed]
  • 2. Campbell JA. Effects of Precipitated Silica and of Iron Oxide on the Incidence of Primary Lung Tumours in Mice. Br Med J. 1940; 2(4156): 275-80[PubMed]
  • 3. Hann HW, Stahlhut MW, Menduke H. Iron enhances tumor growth. Observation on spontaneous mammary tumors in mice. Cancer. 1991; 68: 2407-10
  • 4. Daniels TR, Bernabeu E, Rodriguez JA, Patel S, Kozman M, Chiappetta DA, et al. The transferrin receptor and the targeted delivery of therapeutic agents against cancer. Biochim Biophys Acta. 2012; 1820(3): 291-317[DOI][PubMed]
  • 5. Leng X, Wu Y, Arlinghaus RB. Relationships of lipocalin 2 with breast tumorigenesis and metastasis. J Cell Physiol. 2011; 226(2): 309-14[DOI][PubMed]
  • 6. Zhang Y, Fan Y, Mei Z. NGAL and NGALR overexpression in human hepatocellular carcinoma toward a molecular prognostic classification. Cancer Epidemiol. 2012; 36(5): 294-9[DOI][PubMed]
  • 7. Shpyleva SI, Tryndyak VP, Kovalchuk O, Starlard-Davenport A, Chekhun VF, Beland FA, et al. Role of ferritin alterations in human breast cancer cells. Breast Cancer Res Treat. 2011; 126(1): 63-71[DOI][PubMed]
  • 8. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306(5704): 2090-3[DOI][PubMed]
  • 9. Kwok JC, Richardson DR. The iron metabolism of neoplastic cells: alterations that facilitate proliferation? Crit Rev Oncol Hematol. 2002; 42(1): 65-78[PubMed]
  • 10. Marcus DM, Zinberg N. Measurement of serum ferritin by radioimmunoassay: results in normal individuals and patients with breast cancer. J Natl Cancer Inst. 1975; 55(4): 791-5[PubMed]
  • 11. Richardson DR, Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997; 1331(1): 1-40[PubMed]
  • 12. Hann HW, Levy HM, Evans AE. Serum ferritin as a guide to therapy in neuroblastoma. Cancer Res. 1980; 40(5): 1411-3[PubMed]
  • 13. Bauer M, Eickhoff JC, Gould MN, Mundhenke C, Maass N, Friedl A. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat. 2008; 108(3): 389-97[DOI][PubMed]
  • 14. Cho H, Kim JH. Lipocalin2 expressions correlate significantly with tumor differentiation in epithelial ovarian cancer. J Histochem Cytochem. 2009; 57(5): 513-21[DOI][PubMed]
  • 15. Mannelqvist M, Stefansson IM, Wik E, Kusonmano K, Raeder MB, Oyan AM, et al. Lipocalin 2 expression is associated with aggressive features of endometrial cancer. BMC Cancer. 2012; 12: 169[DOI][PubMed]
  • 16. Barresi V, Reggiani-Bonetti L, Di Gregorio C, Vitarelli E, Ponz De Leon M, Barresi G. Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in stage I colorectal carcinoma. Pathol Res Pract. 2011; 207(8): 479-86[DOI][PubMed]
  • 17. Linnerth NM, Sirbovan K, Moorehead RA. Use of a transgenic mouse model to identify markers of human lung tumors. Int J Cancer. 2005; 114(6): 977-82[DOI][PubMed]
  • 18. Moniaux N, Chakraborty S, Yalniz M, Gonzalez J, Shostrom VK, Standop J, et al. Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia. Br J Cancer. 2008; 98(9): 1540-7[DOI][PubMed]
  • 19. Morrone G, Corbo L, Turco MC, Pizzano R, De Felice M, Bridges S, et al. Transferrin-like autocrine growth factor, derived from T-lymphoma cells, that inhibits normal T-cell proliferation. Cancer Res. 1988; 48(12): 3425-9[PubMed]
  • 20. Zhang S, Chen Y, Guo W, Yuan L, Zhang D, Xu Y, et al. Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cell Signal. 2014; 26(11): 2539-50[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments