Iranian Journal of Pediatrics

Published by: Kowsar

Level of Interleukin 37 (IL-37) in Children with Systemic Lupus Erythematosus and Its Correlation with Disease Activity

Emad E Ghobrial 1 , * , Huda M Marzouk 1 , Mervat M Khorshied 1 and Mai G Sayed 1
Authors Information
1 Pediatric Rheumatology Clinic, Children’s Hospital, Faculty of Medicine, Cairo University
Article information
  • Iranian Journal of Pediatrics: February 2018, 28 (1); e11377
  • Published Online: December 23, 2017
  • Article Type: Research Article
  • Received: April 27, 2017
  • Revised: August 25, 2017
  • Accepted: November 16, 2017
  • DOI: 10.5812/ijp.11377

To Cite: Ghobrial E E, Marzouk H M, Khorshied M M, Sayed M G. Level of Interleukin 37 (IL-37) in Children with Systemic Lupus Erythematosus and Its Correlation with Disease Activity, Iran J Pediatr. 2018 ; 28(1):e11377. doi: 10.5812/ijp.11377.

Copyright © 2017, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Song L, Qiu F, Fan Y, Ding F, Liu H, Shu Q, et al. Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus. J Clin Immunol. 2013;33(1):111-7. doi: 10.1007/s10875-012-9791-z. [PubMed: 22961070].
  • 2. Watson L, Gohar F, Beresford MW. Diagnosis and management of juvenile-onset SLE. Paediatr Child Health. 2011;21(12):539-45. doi: 10.1016/j.paed.2011.06.005.
  • 3. Commins SP, Borish L, Steinke JW. Immunologic messenger molecules: cytokines, interferons, and chemokines. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S53-72. doi: 10.1016/j.jaci.2009.07.008. [PubMed: 19932918].
  • 4. Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E, et al. Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2011;127(3):701-21 e1-70. doi: 10.1016/j.jaci.2010.11.050. [PubMed: 21377040].
  • 5. Boraschi D, Lucchesi D, Hainzl S, Leitner M, Maier E, Mangelberger D, et al. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw. 2011;22(3):127-47. doi: 10.1684/ecn.2011.0288. [PubMed: 22047735].
  • 6. Ye L, Ji L, Wen Z, Zhou Y, Hu D, Li Y, et al. IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity. J Transl Med. 2014;12:69. doi: 10.1186/1479-5876-12-69. [PubMed: 24629023].
  • 7. Petri M, Orbai AM, Alarcon GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64(8):2677-86. doi: 10.1002/art.34473. [PubMed: 22553077].
  • 8. Gladman DD, Goldsmith CH, Urowitz MB, Bacon P, Fortin P, Ginzler E, et al. The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index for Systemic Lupus Erythematosus International Comparison. J Rheumatol. 2000;27(2):373-6. [PubMed: 10685799].
  • 9. Bolton S, Bon C. Pharmaceutical statistics: Practical and Clinical Applications. 5th ed. Broken Sound Parkway, NW: Taylor and Franciṣ; 2009.
  • 10. Yap DY, Lai KN. The role of cytokines in the pathogenesis of systemic lupus erythematosus - from bench to bedside. Nephrology (Carlton). 2013;18(4):243-55. doi: 10.1111/nep.12047. [PubMed: 23452295].
  • 11. Zhao JJ, Pan QZ, Pan K, Weng DS, Wang QJ, Li JJ, et al. Interleukin-37 mediates the antitumor activity in hepatocellular carcinoma: role for CD57+ NK cells. Sci Rep. 2014;4:5177. doi: 10.1038/srep05177. [PubMed: 24898887].
  • 12. Pisoni CN, Munoz SA, Carrizo C, Cosatti M, Alvarez A, Dubinsky D, et al. Multicentric prevalence study of anti P ribosomal autoantibodies in juvenile onset systemic lupus erythematosus compared with adult onset systemic lupus erythematosus. Reumatol Clin. 2015;11(2):73-7. doi: 10.1016/j.reuma.2014.03.007. [PubMed: 24816340].
  • 13. Youssef DM, Tawfek DM, Mohammed AM, Mohammed R, Khalifa NA. Pediatric systemic lupus erythematosus in a single nephrology unit. Saudi J Kidney Dis Transpl. 2015;26(2):314-9. doi: 10.4103/1319-2442.152493. [PubMed: 25758881].
  • 14. Abdwani R, Abdulla E, Yaroubi S, Bererhi H, Al-Zakwani I. Bone mineral density in juvenile onset systemic lupus erythematosus. Indian Pediatr. 2015;52(1):38-40. doi: 10.1007/s13312-015-0564-7. [PubMed: 25638183].
  • 15. Lotfy HM, Halawa EF, El Baz M. Pulmonary involvement in juvenile-onset systemic lupus erythematosus patients asymptomatic for respiratory disease. Egypt J Bronchol. 2015;9(1):59-63.
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