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Effect of Oral Ondansetron on Decreasing the Vomiting Associated with Acute Gastroenteritis in Iranian Children

AUTHORS

Hamidreza Badeli 1 , * , Kioomars Golshekan 2 , Saman Rezaieian 3 , Haniyeh Mohammadpour 4 , Afagh Hassanzadehrad 5

AUTHORS INFORMATION

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How to Cite: Badeli H, Golshekan K, Rezaieian S, Mohammadpour H, Hassanzadehrad A . Effect of Oral Ondansetron on Decreasing the Vomiting Associated with Acute Gastroenteritis in Iranian Children, Iran J Pediatr. 2013 ; 23(5):557-563.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 23 (5); 557-563
Published Online: July 24, 2013
Article Type: Research Article
Received: October 13, 2012
Accepted: June 21, 2013

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Abstract

Objective: The aim of this study was to determine the effect of oral ondansetron in decreasing the vomiting due to acute gastroenteritis in children. Methods: In a single center, randomized, double blind, controlled trial, the effect of oral ondansetron was compared with placebo on 176 patients between 1 and 10 years old with acute gastroenteritis. 30 minutes after drug administration, oral rehydration therapy (ORT) was initiated. Severity of vomiting was evaluated during emergency department (ED) stay and 48 hours follow up. Data were collected and analyzed by SPSS16. Findings: Fifty two of children (58.5%) were males with the mean age of 3.12 (±2.30) years. Ten patients in ondansetron and 14 in placebo group had persistent vomiting during ED stay. After analyzing, there was no significant relation between vomiting in 4 and 48 hours and need for intra venous fluid therapy between the two groups although ondansetron generally decreased ORT failure (P=0.03). Conclusion: Although administrayion of oral ondansetron in gastroenteritis could decrease failure of ORT, it seems that further well-conducted clinical studies are needed to determine effects of oral ondansetron precisely.

 

Keywords

Ondansetron Acute Gastroenteritis Vomiting Oral Rehydration Therapy

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