IF: 0.587
Cite Score:
0.7
THOMSON REUTERS - SCOPUS

Colonization with Clostridium difficile in Children with Cancer

AUTHORS

Shahnaz Armin 1 , * , Shahin Shamsian 2 , Hojatollah Drakhshanfar 3

AUTHORS INFORMATION

1

2

3

How to Cite: Armin S, Shamsian S, Drakhshanfar H. Colonization with Clostridium difficile in Children with Cancer, Iran J Pediatr. 2013 ; 23(4):473-476.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 23 (4); 473-476
Published Online: March 07, 2013
Article Type: Rapid Communication
Received: July 29, 2012
Accepted: February 25, 2013

Crossmark

CHEKING

READ FULL TEXT
Abstract

Objective: Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus. Usually it does not cause disease unless a patient who is colonized with toxin-producing strains has been treated with antibiotics, particularly those that change the anaerobic flora of the large intestine. Methods: We investigated in a prospective study intestinal colonization of C. difficile and its toxins in children with malignancy that used different antibiotics and cytotoxic drugs. Findings: One hundred fifty-two patients were included in this prospective study. Stool samples were obtained within the first 48 hours after admission and cultured for C. difficile; cytopathic effect of C. difficile was detected on HELA cells, also ELISA test was performed for detection of toxins A and B. 25% of patients had positive culture for C. difficile; 36/38 (92%) revealed positive cytopathic effect on HELA cells. No significant relation was found between age, gender, history of antibiotic consumption and C. difficile positive culture and cytopathic effect on HELA cells. The only relation was seen between cotrimoxazol usage and cytopathic effect on HELA cells (P=0.03). Conclusion: Although the rate of C. difficile colonization (25.6%) and toxigenic strains (23.7%) in admitted children in hematologic ward is high, the rate of ELISA positive test for toxin A+B was not correspond with culture and cytopatic effect on HELA cell. With respect to sensitivity and specificity of ELISA test, possibility for existence of toxin C with cytopathic effect is high in this type of patients.

 

Keywords

Colonization Clostridium Difficile Cancer Cytopathic Effect

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

References

  • 1. References are available on the PDF.
  • COMMENTS

    LEAVE A COMMENT HERE: