Iranian Journal of Pediatrics

Published by: Kowsar

Evaluation of Serum Adenosine Deaminase in Cystic Fibrosis Patients in an Iranian Referral Hospital

Fatemeh Farahmand 1 , 2 , Parisa Tajdini 3 , * , Gholamhossein Falahi 1 , 2 , Sedigheh Shams 2 , 3 and Shima Mahmoudi 4
Authors Information
1 Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran
2 Children’s Medical Center, Pediatrics Center of Excellence, Tehran, IR Iran
3 Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
4 Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Journal of Pediatrics: June 2016, 26 (3); e2246
  • Published Online: February 10, 2016
  • Article Type: Research Article
  • Received: February 20, 2015
  • Revised: April 22, 2015
  • Accepted: May 5, 2015
  • DOI: 10.5812/ijp.2246

To Cite: Farahmand F, Tajdini P, Falahi G, Shams S, Mahmoudi S. Evaluation of Serum Adenosine Deaminase in Cystic Fibrosis Patients in an Iranian Referral Hospital, Iran J Pediatr. 2016 ; 26(3):e2246. doi: 10.5812/ijp.2246.

Copyright © 2016, Growth & Development Research Center.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Chunn JL, Mohsenin A, Young HW, Lee CG, Elias JA, Kellems RE, et al. Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations. Am J Physiol Lung Cell Mol Physiol. 2006; 290(3)-87[DOI][PubMed]
  • 2. Cristalli G, Costanzi S, Lambertucci C, Lupidi G, Vittori S, Volpini R, et al. Adenosine deaminase: functional implications and different classes of inhibitors. Med Res Rev. 2001; 21(2): 105-28[PubMed]
  • 3. Walker BA, Jacobson MA, Knight DA, Salvatore CA, Weir T, Zhou D, et al. Adenosine A3 receptor expression and function in eosinophils. Am J Respir Cell Mol Biol. 1997; 16(5): 531-7[DOI][PubMed]
  • 4. Young HW, Molina JG, Dimina D, Zhong H, Jacobson M, Chan LN, et al. A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice. J Immunol. 2004; 173(2): 1380-9[PubMed]
  • 5. Blackburn MR, Lee CG, Young HW, Zhu Z, Chunn JL, Kang MJ, et al. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest. 2003; 112(3): 332-44[DOI][PubMed]
  • 6. Blackburn MR, Kellems RE. Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation. Adv Immunol. 2005; 86: 1-41[DOI][PubMed]
  • 7. Apasov SG, Blackburn MR, Kellems RE, Smith PT, Sitkovsky MV. Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling. J Clin Invest. 2001; 108(1): 131-41[DOI][PubMed]
  • 8. Afrasiabian S, Mohsenpour B, Haji Bagheri K, Sigari N, Aftabi K. Diagnostic value of serum adenosine deaminase level in pulmonary tuberculosis. J Res Med Sci. 2013; 18(3): 252
  • 9. Chander A, Shrestha CD. Diagnostic value of serum adenosine deaminase levels in sputum smear negative pulmonary tuberculosis patients in Nepalese population. Asian Pac J Trop Biomed. 2012; 2(3)-9[DOI]
  • 10. Feliu MS, Perris P, Slobodianik N. Adenosine deaminase: as indicator of nutritional status. FASEB J. 2008; 22(1 MeetingAbstracts): 1102.2
  • 11. Goodarzi MT, Abdi M, Tavilani H, Nadi E, Rashidi M. Adenosine deaminase activity in COPD patients and healthy subjects. Iran J Allergy Asthma Immunol. 2010; 9(1): 7-12[PubMed]
  • 12. Vass G, Horvath I. Adenosine and adenosine receptors in the pathomechanism and treatment of respiratory diseases. Curr Med Chem. 2008; 15(9): 917-22[PubMed]
  • 13. Aldrich MB, Blackburn MR, Kellems RE. The importance of adenosine deaminase for lymphocyte development and function. Biochem Biophys Res Commun. 2000; 272(2): 311-5[DOI][PubMed]
  • 14. Bagheri-Hanson A, Nedwed S, Rueckes-Nilges C, Naehrlich L. Intestinal current measurement versus nasal potential difference measurements for diagnosis of cystic fibrosis: a case-control study. BMC Pulm Med. 2014; 14: 156[DOI][PubMed]
  • 15. De Boeck K, Wilschanski M, Castellani C, Taylor C, Cuppens H, Dodge J, et al. Cystic fibrosis: terminology and diagnostic algorithms. Thorax. 2006; 61(7): 627-35[DOI][PubMed]
  • 16. Chunn JL, Molina JG, Mi T, Xia Y, Kellems RE, Blackburn MR. Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice. J Immunol. 2005; 175(3): 1937-46[PubMed]
  • 17. Perris P, Feliu MS, Barbeito S, Strasnoy I, Ferraro M, Slobodianik N. Serum C3c and C4c concentrations and adenosine deaminase activity of children with cystic fibrosis: preliminary study. Proc Nutr Soc. 2008; 67
  • 18. Hirsh AJ, Stonebraker JR, van Heusden CA, Lazarowski ER, Boucher RC, Picher M. Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. Biochemistry. 2007; 46(36): 10373-83[DOI][PubMed]
  • 19. Arispe N, Ma J, Jacobson KA, Pollard HB. Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX). J Biol Chem. 1998; 273(10): 5727-34[PubMed]
  • 20. Banerjee SK, Young HW, Barczak A, Erle DJ, Blackburn MR. Abnormal alveolar development associated with elevated adenine nucleosides. Am J Respir Cell Mol Biol. 2004; 30(1): 38-50[DOI][PubMed]
  • 21. Blackburn MR, Volmer JB, Thrasher JL, Zhong H, Crosby JR, Lee JJ, et al. Metabolic Consequences of Adenosine Deaminase Deficiency in Mice Are Associated with Defects in Alveogenesis, Pulmonary Inflammation, and Airway Obstruction. J Exper Med. 2000; 192(2): 159-70[DOI]
  • 22. Caruso M, Alamo A, Crisafulli E, Raciti C, Fisichella A, Polosa R. Adenosine signaling pathways as potential therapeutic targets in respiratory disease. Expert Opin Ther Targets. 2013; 17(7): 761-72[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments