Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections

Alireza Monsef; Fatemeh  Eghbalian

Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections

Alireza Monsef ¹ and Fatemeh Eghbalian ^{2
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Authors Information

¹ 1. Pathology department, Hamadan University of Medical Sciences, Hamadan, Iran

² 2. Pediatrics department, Hamadan University of Medical Sciences, Hamadan

Article information

Iranian Journal of Pediatrics: September 15, 2015, 22 (3); 314-318
Published Online: September 30, 2012
Article Type: Research Article
Received: July 09, 2011
Accepted: March 10, 2012

To Cite: Monsef A, Eghbalian F . Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections , Iran J Pediatr. 2015 ;22(3):314-318.

Abstract

Objective: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections.
Methods: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospital in Hamedan province, Iran. 39 symptomatic infants with clinical and laboratory findings in favor of bacterial infection with a positive blood, CSF, and/or supra pubic urine culture entered the study; 32 newborns without any bacterial infection served as control group. Quantitative procalcitonin level ≥0.5 ng/ml was accepted as pathological. Finally sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated for procalcitonin test.
Findings: 20 blood cultures, 17 urine cultures and 8 CSF cultures were positive. Sensitivity, specificity, PPV and NPV for procalcitonin test was 76.9%, 100%, 100% and 78% respectively. Diagnostic value of procalcitonin test in accordance with blood culture for mentioned items was 85%, 100%, 100% and 91.4% respectively. Its diagnostic value according to urine culture was: sensitivity 70.6%, specificity 100%, PPV 100% and NPV 86.4%, and according to CSF culture was: sensitivity 75%, specificity 100%, PPV 100% and NPV 94.1% respectively.
Conclusion: The results show that the procalcitonin test has high sensitivity, specificity, PPV and NPV for diagnosis of neonatal infections.

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