Can Urinary Nitrite Results Be Used to Conduct Antimicrobial Option for Urinary Tract Infection in Children?

AUTHORS

Ameneh Barikani 1 , Mohammad-Mahdi Daneshi-Kohan 2 , Mahta Froozesh 3 , Parviz Ayazi 3 , Abolfazl Mahyar 3 , *

1 Department of Social Sciences, Qazvin university of Medical Sciences, Qazvin, Iran

2 Department of Diagnostic laboratory Medicine, Qazvin university of Medical Sciences, Qazvin, Iran

3 Department of Pediatrics, Qazvin university of Medical Sciences, Qazvin, Iran

How to Cite: Barikani A, Daneshi-Kohan M, Froozesh M, Ayazi P, Mahyar A. Can Urinary Nitrite Results Be Used to Conduct Antimicrobial Option for Urinary Tract Infection in Children?, Iran J Pediatr. 2015 ; 22(2):237-240.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 22 (2); 237-240
Published Online: June 30, 2012
Article Type: Research Article
Received: March 30, 2011
Accepted: October 25, 2011

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Abstract

Objective: This study was performed to determine the relationship between urinary nitrite results and bacterial resistance to antimicrobial drugs in urinary tract infection of children.
Methods: In a cross-section study 119 children younger than 12 years with urinary tract infection were evaluated in Qazvin children's hospital. Patients were divided into negative and positive nitrite groups depending on urinary nitrite test result. Rates of antibiotic resistance in the two groups were compared.
Findings: Sixty seven patients were in the negative nitrite group and 52 in the positive nitrite group. Resistance rates to ceftriaxone, trimethoprim sulfamethoxazole, ampicillin, gentamicin, amikacin, nalidixic acid, cephalothin and nitrofurantoin in the nitrite negative group were 7.5%, 31.3%, 50.7%, 11.9%, 9%, 3%, 14.9% and 11.9%, respectively. These values in the nitrite positive group were 21.2%, 28.8%, 63.5%, 7.7%, 5.8%, 1.9%, 9.6%, and 3.8%, respectively (P>0.05).
Conclusion: This study showed that there is no correlation between urinary nitrite results and bacterial resistance to antimicrobial drugs. Therefore, it seems that physicians should not adjust antibiotic therapy for UTI based on nitrite results.

 

Keywords

Urinary Tract Infections Nitrite Anti-bacterial agents Drug resistance

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