Evaluation oF Epicardial Fat and Carotid Intima-Media Thickness in Obese Children

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To Cite : Elshorbagy H H, Fouda E R, Kamal N M, Bassiouny M M, Fathi W M. et al. Evaluation oF Epicardial Fat and Carotid Intima-Media Thickness in Obese Children, Iran J Pediatr. 2016 ;26(1):e2968. doi: 10.5812/ijp.2968.
Abstract
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Van Putte-Katier N, Rooman RP, Haas L, Verhulst SL, Desager KN, Ramet J, et al. Early cardiac abnormalities in obese children: importance of obesity per se versus associated cardiovascular risk factors. Pediatr Res. 2008; 64(2): 205-9[DOI][PubMed]
  • 2. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C, American Heart A, et al. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004; 109(3): 433-8[DOI][PubMed]
  • 3. Ozdemir O, Hizli S, Abaci A, Agladioglu K, Aksoy S. Echocardiographic measurement of epicardial adipose tissue in obese children. Pediatr Cardiol. 2010; 31(6): 853-60[DOI][PubMed]
  • 4. Voulgari C, Moyssakis I, Papazafiropoulou A, Perrea D, Kyriaki D, Katsilambros N, et al. The impact of metabolic syndrome on left ventricular myocardial performance. Diabetes Metab Res Rev. 2010; 26(2): 121-7[DOI][PubMed]
  • 5. Gastaldelli A, Basta G. Ectopic fat and cardiovascular disease: what is the link? Nutr Metab Cardiovasc Dis. 2010; 20(7): 481-90[DOI][PubMed]
  • 6. Sacks HS, Fain JN. Human epicardial adipose tissue: a review. Am Heart J. 2007; 153(6): 907-17[DOI][PubMed]
  • 7. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000; 320(7244): 1240-3[PubMed]
  • 8. Shea S, Aymong E, Zybert P, Shamoon H, Tracy RP, Deckelbaum RJ, et al. Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children. Obes Res. 2003; 11(1): 95-103[DOI][PubMed]
  • 9. Vikram NK, Misra A, Dwivedi M, Sharma R, Pandey RM, Luthra K, et al. Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescents and young adults in urban North India. Atherosclerosis. 2003; 168(2): 305-13[PubMed]
  • 10. Roberts WL, Moulton L, Law TC, Farrow G, Cooper-Anderson M, Savory J, et al. Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2. Clin Chem. 2001; 47(3): 418-25[PubMed]
  • 11. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics. 2005; 115(4)-3[DOI][PubMed]
  • 12. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978; 58(6): 1072-83[PubMed]
  • 13. Devereux RB, Lutas EM, Casale PN, Kligfield P, Eisenberg RR, Hammond IW, et al. Standardization of M-mode echocardiographic left ventricular anatomic measurements. J Am Coll Cardiol. 1984; 4(6): 1222-30[PubMed]
  • 14. Spirito P, Maron BJ, Bonow RO. Noninvasive assessment of left ventricular diastolic function: comparative analysis of Doppler echocardiographic and radionuclide angiographic techniques. J Am Coll Cardiol. 1986; 7(3): 518-26[PubMed]
  • 15. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003; 88(11): 5163-8[DOI][PubMed]
  • 16. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, et al. Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis. 2007; 23(1): 75-80[DOI][PubMed]
  • 17. Spirito P, Maron BJ, Bonow RO. Noninvasive assessment of left ventricular diastolic function: Comparative analysis of Doppler echocardiographic and radionuclide angiographic techniques. J Am Coll Cardiol. 1986; 7(3): 518-26[DOI]
  • 18. Cote AT, Harris KC, Panagiotopoulos C, Sandor GG, Devlin AM. Childhood obesity and cardiovascular dysfunction. J Am Coll Cardiol. 2013; 62(15): 1309-19[DOI][PubMed]
  • 19. Abaci A, Tascilar ME, Saritas T, Yozgat Y, Yesilkaya E, Kilic A, et al. Threshold value of subepicardial adipose tissue to detect insulin resistance in obese children. Int J Obes (Lond). 2009; 33(4): 440-6[DOI][PubMed]
  • 20. Boyraz M, Pirgon O, Akyol B, Dundar B, Cekmez F, Eren N. Importance of epicardial adipose tissue thickness measurement in obese adolescents, its relationship with carotid intima-media thickness, and echocardiographic findings. Eur Rev Med Pharmacol Sci. 2013; 17(24): 3309-17[PubMed]
  • 21. Eren E, Koca B, Ture M, Guzel B. Epicardial adiposity in children with obesity and metabolic syndrome. Iran J Pediatr. 2014; 24(4): 411-7[PubMed]
  • 22. Mason C, Craig CL, Katzmarzyk PT. Influence of central and extremity circumferences on all-cause mortality in men and women. Obesity (Silver Spring). 2008; 16(12): 2690-5[DOI][PubMed]
  • 23. Janssen I, Katzmarzyk PT, Ross R. Waist circumference and not body mass index explains obesity-related health risk. Am J Clin Nutr. 2004; 79(3): 379-84[PubMed]
  • 24. Despres JP. Is visceral obesity the cause of the metabolic syndrome? Ann Med. 2006; 38(1): 52-63[DOI][PubMed]
  • 25. Akyol B, Boyraz M, Aysoy C. Relationship of epicardial adipose tissue thickness with early indicators of atherosclerosis and cardiac functional changes in obese adolescents with metabolic syndrome. J Clin Res Pediatr Endocrinol. 2013; 5(3): 156-63[DOI][PubMed]
  • 26. Blachnio-Zabielska AU, Baranowski M, Hirnle T, Zabielski P, Lewczuk A, Dmitruk I, et al. Increased bioactive lipids content in human subcutaneous and epicardial fat tissue correlates with insulin resistance. Lipids. 2012; 47(12): 1131-41[DOI][PubMed]
  • 27. Fernandez Munoz MJ, Basurto Acevedo L, Cordova Perez N, Vazquez Martinez AL, Tepach Gutierrez N, Vega Garcia S, et al. Epicardial adipose tissue is associated with visceral fat, metabolic syndrome, and insulin resistance in menopausal women. Rev Esp Cardiol (Engl Ed). 2014; 67(6): 436-41[DOI][PubMed]
  • 28. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003; 108(20): 2460-6[DOI][PubMed]
  • 29. Pierdomenico SD, Pierdomenico AM, Cuccurullo F, Iacobellis G. Meta-analysis of the relation of echocardiographic epicardial adipose tissue thickness and the metabolic syndrome. Am J Cardiol. 2013; 111(1): 73-8[DOI][PubMed]
  • 30. Alam MS, Green R, de Kemp R, Beanlands RS, Chow BJ. Epicardial adipose tissue thickness as a predictor of impaired microvascular function in patients with non-obstructive coronary artery disease. J Nucl Cardiol. 2013; 20(5): 804-12[DOI][PubMed]
  • 31. Tamarappoo B, Dey D, Shmilovich H, Nakazato R, Gransar H, Cheng VY, et al. Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. JACC Cardiovasc Imaging. 2010; 3(11): 1104-12[DOI][PubMed]
  • 32. Cavalcante JL, Tamarappoo BK, Hachamovitch R, Kwon DH, Alraies MC, Halliburton S, et al. Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction. Am J Cardiol. 2012; 110(12): 1793-8[DOI][PubMed]
  • 33. Khawaja T, Greer C, Chokshi A, Chavarria N, Thadani S, Jones M, et al. Epicardial fat volume in patients with left ventricular systolic dysfunction. Am J Cardiol. 2011; 108(3): 397-401[DOI][PubMed]
  • 34. Tei C, Ling LH, Hodge DO, Bailey KR, Oh JK, Rodeheffer RJ, et al. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function--a study in normals and dilated cardiomyopathy. J Cardiol. 1995; 26(6): 357-66[PubMed]
  • 35. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007; 115(4): 459-67[DOI][PubMed]
  • 36. Aydin H, Toprak A, Deyneli O, Yazici D, Tarcin O, Sancak S, et al. Epicardial fat tissue thickness correlates with endothelial dysfunction and other cardiovascular risk factors in patients with metabolic syndrome. Metab Syndr Relat Disord. 2010; 8(3): 229-34[DOI][PubMed]
  • 37. Iacobellis G, Barbarini G, Letizia C, Barbaro G. Epicardial fat thickness and nonalcoholic fatty liver disease in obese subjects. Obesity (Silver Spring). 2014; 22(2): 332-6[DOI][PubMed]
  • 38. Alexopoulos N, McLean DS, Janik M, Arepalli CD, Stillman AE, Raggi P. Epicardial adipose tissue and coronary artery plaque characteristics. Atherosclerosis. 2010; 210(1): 150-4[DOI][PubMed]
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