Iranian Journal of Pediatrics

Published by: Kowsar

Evaluation of Neurodevelopment and Factors Affecting it in Children With Acyanotic Congenital Cardiac Disease

Ayten Ozmen 1 , Semiha Terlemez 2 , * , Fatma Sedef Tunaoglu 2 , Sebnem Soysal 1 , Ayhan Pektas 2 , Erman Cilsal 2 , Ulker Koca 3 , Serdar Kula 2 and Ayse Deniz Oguz 2
Authors Information
1 Department of Pediatrics, Faculty of Medicine, Gazi University, Ankara, Turkey
2 Pediatric Cardiology Department, Faculty of Medicine, Gazi University, Ankara, Turkey
3 Pediatric Hematology Department, Faculty of Medicine Gazi University, Ankara, Turkey
Article information
  • Iranian Journal of Pediatrics: February 28, 2016, 26 (1); e3278
  • Published Online: January 30, 2016
  • Article Type: Research Article
  • Received: June 29, 2015
  • Revised: October 17, 2015
  • Accepted: November 2, 2015
  • DOI: 10.5812/ijp.3278

To Cite: Ozmen A, Terlemez S, Tunaoglu F S, Soysal S, Pektas A, et al. Evaluation of Neurodevelopment and Factors Affecting it in Children With Acyanotic Congenital Cardiac Disease, Iran J Pediatr. 2016 ; 26(1):e3278. doi: 10.5812/ijp.3278.

Copyright © 2016, Growth & Development Research Center.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Boneva RS, Botto LD, Moore CA, Yang Q, Correa A, Erickson JD. Mortality associated with congenital heart defects in the United States: trends and racial disparities, 1979-1997. Circulation. 2001; 103(19): 2376-81[PubMed]
  • 2. Limperopoulos C, Majnemer A, Shevell MI, Rosenblatt B, Rohlicek C, Tchervenkov C. Neurodevelopmental status of newborns and infants with congenital heart defects before and after open heart surgery. J Pediatr. 2000; 137(5): 638-45[DOI][PubMed]
  • 3. Limperopoulos C, Majnemer A, Shevell MI, Rosenblatt B, Rohlicek C, Tchervenkov C. Neurologic status of newborns with congenital heart defects before open heart surgery. Pediatrics. 1999; 103(2): 402-8[PubMed]
  • 4. Licht DJ, Shera DM, Clancy RR, Wernovsky G, Montenegro LM, Nicolson SC, et al. Brain maturation is delayed in infants with complex congenital heart defects. J Thorac Cardiovasc Surg. 2009; 137(3): 529-36[DOI][PubMed]
  • 5. Donofrio MT, Massaro AN. Impact of congenital heart disease on brain development and neurodevelopmental outcome. Int J Pediatr. 2010; 2010[DOI][PubMed]
  • 6. Newburger JW, Bellinger DC. Brain injury in congenital heart disease. Circulation. 2006; 113(2): 183-5[DOI][PubMed]
  • 7. Marino BS, Lipkin PH, Newburger JW, Peacock G, Gerdes M, Gaynor JW, et al. Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management: a scientific statement from the American Heart Association. Circulation. 2012; 126(9): 1143-72[DOI][PubMed]
  • 8. Bayley N. Bayley Scales of Infant Development. 1993;
  • 9. Guedes DZ, Primi R, Kopelman BI. BINS validation - Bayley neurodevelopmental screener in Brazilian preterm children under risk conditions. Infant Behav Dev. 2011; 34(1): 126-35[DOI][PubMed]
  • 10. Terman LM, Merrill MA. Stanford-Binet intelligence scale: Manual for the third revision, form lM. 1960;
  • 11. Aktas D, Utine EG, Mrasek K, Weise A, von Eggeling F, Yalaz K, et al. Derivative chromosome 1 and GLUT1 deficiency syndrome in a sibling pair. Mol Cytogenet. 2010; 3(1): 10[DOI][PubMed]
  • 12. Anlar B, Yalaz K. Denver II Developmental screening test, its adaptation to turkish children and standardization. 1995; : 1-43
  • 13. Tunc B. Iron deficiency anemia in children. TURK Child Hosp J. 2008; 2(2): 43-57
  • 14. Utens EM, Verhulst FC, Meijboom FJ, Duivenvoorden HJ, Erdman RA, Bos E, et al. Behavioural and emotional problems in children and adolescents with congenital heart disease. Psychol Med. 1993; 23(2): 415-24[PubMed]
  • 15. Bellinger DC, Newburger JW. Neuropsychological, psychosocial, and quality-of-life outcomes in children and adolescents with congenital heart disease. Prog Pediatr Cardiol. 2010; 29(2): 87-92
  • 16. Dogangun B. Psyhchiatric conditions requiring private education. I.U. Cerrahpasa medicine faculty continuing education events most encountered psychiatric diseases symposium series. 2008; : 157-74
  • 17. Aydın H, Diler RS, Yurdagul E, Oguz S. Attention deficit hyperactivity disorder Rate in Parents of Children Diagnosed with attention deficit hyperactivity disorder. Klin Psikiyatr Derg. 2006; : 70-4
  • 18. McCann JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr. 2007; 85(4): 931-45[PubMed]
  • 19. Beard JL, Wiesinger JA, Connor JR. Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats. Dev Neurosci. 2003; 25(5): 308-15[DOI][PubMed]
  • 20. Youdim MB, Yehuda S. The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamine-opiate system. Cell Mol Biol (Noisy-le-grand). 2000; 46(3): 491-500[PubMed]
  • 21. Beard JL, Felt B, Schallert T, Burhans M, Connor JR, Georgieff MK. Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res. 2006; 170(2): 224-32[DOI][PubMed]
  • 22. Tunaoglu FS, Gursel T, Bozkurt A, et al. . The effect of iron deficiency on platelet 5-hydroxytryptamine levels and relation to behavioral abnormalities. Acta Pediatr. 1991; (7): 35-7
  • 23. Broberg CS, Bax BE, Okonko DO, Rampling MW, Bayne S, Harries C, et al. Blood viscosity and its relationship to iron deficiency, symptoms, and exercise capacity in adults with cyanotic congenital heart disease. J Am Coll Cardiol. 2006; 48(2): 356-65[DOI][PubMed]
  • 24. Tay EL, Peset A, Papaphylactou M, Inuzuka R, Alonso-Gonzalez R, Giannakoulas G, et al. Replacement therapy for iron deficiency improves exercise capacity and quality of life in patients with cyanotic congenital heart disease and/or the Eisenmenger syndrome. Int J Cardiol. 2011; 151(3): 307-12[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments