Iranian Journal of Pediatrics

Published by: Kowsar

Vitamin D Supplementation and High-Density Lipoprotein Cholesterol: A Study in Healthy School Children

Fatemeh Tavakoli 1 , Kokab Namakin 1 , * and Mahmood Zardast 2
Authors Information
1 Department of Pediatrics, Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, IR Iran
2 Department of Pathology, School of Medicine, Birjand University of Medical Sciences, Birjand, IR Iran
Article information
  • Iranian Journal of Pediatrics: August 2016, 26 (4); e3311
  • Published Online: July 27, 2016
  • Article Type: Research Article
  • Received: July 7, 2015
  • Revised: February 20, 2016
  • Accepted: March 12, 2016
  • DOI: 10.5812/ijp.3311

To Cite: Tavakoli F, Namakin K, Zardast M. Vitamin D Supplementation and High-Density Lipoprotein Cholesterol: A Study in Healthy School Children, Iran J Pediatr. 2016 ; 26(4):e3311. doi: 10.5812/ijp.3311.

Copyright © 2016, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Jozanikohan Z, Kazemi Saleh D. A Semi-Experimental Study to Assess Whether the Current Recommended Protocol for Treating Vitamin D Deficiency is Enough? Iran Red Crescent Med J. 2015; 17(7): 22779[DOI][PubMed]
  • 2. Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol. 2014; 2(4): 307-20[DOI][PubMed]
  • 3. Al-Daghri NM, Al-Attas O, Yakout S, Aljohani N, Al-Fawaz H, Alokail MS. Dietary products consumption in relation to serum 25-hydroxyvitamin D and selenium level in Saudi children and adults. Int J Clin Exp Med. 2015; 8(1): 1305-14[PubMed]
  • 4. Rajakumar K, de las Heras J, Chen TC, Lee S, Holick MF, Arslanian SA. Vitamin D status, adiposity, and lipids in black American and Caucasian children. J Clin Endocrinol Metab. 2011; 96(5): 1560-7[DOI][PubMed]
  • 5. Al-Othman A, Al-Musharaf S, Al-Daghri NM, Krishnaswamy S, Yusuf DS, Alkharfy KM, et al. Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents. BMC Pediatr. 2012; 12: 92[DOI][PubMed]
  • 6. Lennon SL, Quindry J, Hamilton KL, French J, Staib J, Mehta JL, et al. Loss of exercise-induced cardioprotection after cessation of exercise. J Appl Physiol (1985). 2004; 96(4): 1299-305[DOI][PubMed]
  • 7. Azizi F, Moemenan AA, Habibi M, Rahmani M. Study of non-HDL cholestrol distribution at age of 3-19 years old (Persian). Iranian J End Metab. 2004; 8(3): 209-14
  • 8. Cruz ML, Goran MI. The metabolic syndrome in children and adolescents. Curr Diab Rep. 2004; 4(1): 53-62[PubMed]
  • 9. Neal WA, John CC. Disorders of lipoprotein metabolism and transport. 2016;
  • 10. Jayachandran M, Okano H, Chatrath R, Owen WG, McConnell JP, Miller VM. Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs. J Appl Physiol (1985). 2004; 97(4): 1445-52[DOI][PubMed]
  • 11. Mozos I, Marginean O. Links between Vitamin D Deficiency and Cardiovascular Diseases. Biomed Res Int. 2015; 2015: 109275[DOI][PubMed]
  • 12. Kelishadi R, Ardalan G, Motlagh ME, Shariatinejad K, Heshmat R, Poursafa P, et al. National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): the CASPIAN-III Study. Nutrition. 2014; 30(1): 33-8[DOI][PubMed]
  • 13. Hovsepian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. J Health Popul Nutr. 2011; 29(2): 149-55[PubMed]
  • 14. Heshmat R, Mohammad K, Majdzadeh SR, Forouzanfar MH, Bahrami A, Ranjbar Omrani GH. Vitamin D deficiency in Iran: A multi-center study among different urban areas. Iran J Public Health. 2008; 37
  • 15. Vitezova A, Voortman T, Zillikens MC, Jansen PW, Hofman A, Uitterlinden AG, et al. Bidirectional associations between circulating vitamin D and cholesterol levels: The Rotterdam Study. Maturitas. 2015; 82(4): 411-7[DOI][PubMed]
  • 16. Nwosu BU, Maranda L, Cullen K, Ciccarelli C, Lee MM. Vitamin D status is associated with early markers of cardiovascular disease in prepubertal children. J Pediatr Endocrinol Metab. 2013; 26(11-12): 1067-75[DOI][PubMed]
  • 17. Williams DM, Fraser A, Sayers A, Fraser WD, Hingorani A, Deanfield J, et al. Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood: cross-sectional findings from the Avon Longitudinal Study of Parents and Children. J Clin Endocrinol Metab. 2012; 97(5): 1563-71[DOI][PubMed]
  • 18. Kelishadi R, Farajzadegan Z, Bahreynian M. Association between vitamin D status and lipid profile in children and adolescents: a systematic review and meta-analysis. Int J Food Sci Nutr. 2014; 65(4): 404-10[DOI][PubMed]
  • 19. Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014; 348: 1903[DOI][PubMed]
  • 20. Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circ Res. 2014; 114(2): 379-93[DOI][PubMed]
  • 21. Williams DM, Fraser A, Sayers A, Fraser WD, Hypponen E, Smith GD, et al. Associations of childhood 25-hydroxyvitamin D2 and D3 and cardiovascular risk factors in adolescence: prospective findings from the Avon Longitudinal Study of Parents and Children. Eur J Prev Cardiol. 2014; 21(3): 281-90[DOI][PubMed]
  • 22. Hirschler V, Maccallini G, Tamborenea MI, Gonzalez C, Sanchez M, Molinari C, et al. Improvement in lipid profile after vitamin D supplementation in indigenous argentine school children. Cardiovasc Hematol Agents Med Chem. 2014; 12(1): 42-9[PubMed]
  • 23. Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S. Relationships between 25-hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients. J Pediatr. 2010; 156(3): 444-9[DOI][PubMed]
  • 24. Birken CS, Lebovic G, Anderson LN, McCrindle BW, Mamdani M, Kandasamy S, et al. Association between Vitamin D and Circulating Lipids in Early Childhood. PLoS One. 2015; 10(7): 131938[DOI][PubMed]
  • 25. Nam GE, Kim do H, Cho KH, Park YG, Han KD, Kim SM, et al. 25-Hydroxyvitamin D insufficiency is associated with cardiometabolic risk in Korean adolescents: the 2008-2009 Korea National Health and Nutrition Examination Survey (KNHANES). Public Health Nutr. 2014; 17(1): 186-94[DOI][PubMed]
  • 26. Maki KC, Rubin MR, Wong LG, McManus JF, Jensen CD, Lawless A. Effects of vitamin D supplementation on 25-hydroxyvitamin D, high-density lipoprotein cholesterol, and other cardiovascular disease risk markers in subjects with elevated waist circumference. Int J Food Sci Nutr. 2011; 62(4): 318-27[DOI][PubMed]
  • 27. Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, Ten S. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab. 2007; 20(7): 817-23[PubMed]
  • 28. Carbone LD, Rosenberg EW, Tolley EA, Holick MF, Hughes TA, Watsky MA, et al. 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. Metabolism. 2008; 57(6): 741-8[DOI][PubMed]
  • 29. Wehmeier K, Beers A, Haas MJ, Wong NC, Steinmeyer A, Zugel U, et al. Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3. Biochim Biophys Acta. 2005; 1737(1): 16-26[DOI][PubMed]
  • 30. Wehmeier KR, Alamir AR, Sultan S, Haas MJ, Wong NC, Mooradian AD. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011; 88(1-2): 110-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments