Iranian Journal of Pediatrics

Published by: Kowsar

Serum Hsp70 Antigen: Early Diagnosis Marker in Perinatal Asphyxia

Hassan Boskabadi 1 , Masoud Omidian 1 , Shima Tavallai 2 , 3 , Shabnam Mohammadi 4 , 5 , Mostafa Parizadeh 2 , 3 , Majid Ghayour Mobarhan 2 , 3 , * and Gordon AA Ferns 6
Authors Information
1 Department of Pediatrics, Neonatal Research Center, Ghaem Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, IR Iran
2 Biochemistry and Nutrition Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, IR Iran
3 Cardiovascular Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, IR Iran
4 Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, IR Iran
5 Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, IR Iran
6 Brighton and Sussex Medical School, Mayfield House, Falmer, Brighton, UK
Article information
  • Iranian Journal of Pediatrics: April 28, 2015, 25 (2)
  • Published Online: April 18, 2015
  • Article Type: Research Article
  • Received: June 3, 2014
  • Accepted: December 28, 2014
  • DOI: 10.5812/ijp.381

To Cite: Boskabadi H, Omidian M, Tavallai S, Mohammadi S, Parizadeh M, et al. Serum Hsp70 Antigen: Early Diagnosis Marker in Perinatal Asphyxia, Iran J Pediatr. 2015 ; 25(2):-. doi: 10.5812/ijp.381.

Copyright © 2015, Growth & Development Research Center.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Jojart G, Nagy G, Pasztor J, Kovacs Z. [Bilateral neonatal adrenal hemorrhage associated with hypoadrenalism]. Orv Hetil. 1992; 133(19): 1179-81[PubMed]
  • 2. Pierrat V, Haouari N, Liska A, Thomas D, Subtil D, Truffert P, Groupe d'Etudes en Epidemiologie P, et al. Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study. Arch Dis Child Fetal Neonatal Ed. 2005; 90(3)-61[DOI][PubMed]
  • 3. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C, Child Health Epidemiology Reference Group of WHO, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet. 2010; 375(9730): 1969-87[DOI][PubMed]
  • 4. Hagmann CF, Brotschi B, Bernet V, Latal B, Berger TM, Robertson NJ. Hypothermia for perinatal asphyxial encephalopathy. Swiss Med Wkly. 2011; 141[DOI][PubMed]
  • 5. Million Death Study C, Bassani DG, Kumar R, Awasthi S, Morris SK, Paul VK, Shet A, Ram U, Gaffey MF, Black RE, Jha P, et al. Causes of neonatal and child mortality in India: a nationally representative mortality survey. Lancet. 2010; 376(9755): 1853-60[DOI][PubMed]
  • 6. Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010; 86(6): 329-38[DOI][PubMed]
  • 7. Garcia-Alix A, Martinez-Biarge M, Diez J, Gaya F, Quero J. [Neonatal hypoxic-ischemic encephalopathy: Incidence and prevalence in the first decade of the 21st century]. An Pediatr (Barc). 2009; 71(4): 319-26[DOI][PubMed]
  • 8. Shah PS, Beyene J, To T, Ohlsson A, Perlman M. Postasphyxial hypoxic-ischemic encephalopathy in neonates: outcome prediction rule within 4 hours of birth. Arch Pediatr Adolesc Med. 2006; 160(7): 729-36[DOI][PubMed]
  • 9. Turturici G, Sconzo G, Geraci F. Hsp70 and its molecular role in nervous system diseases. Biochem Res Int. 2011; 2011: 618127[DOI][PubMed]
  • 10. Arianpour R, Parizadeh MR, Moohebati M. Simvastatin treatment is not associated with changes in serum concentrations of heat shock proteins-60 and -70 in patients with dyslipidemia. Pharmac Sci . 2014; 20: 46-51
  • 11. Farahmand SK, Gang LZ, Saghebi SA, Mohammadi M, Mohammadi S, Mohammadi G, et al. The effects of wet cupping on serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with metabolic syndrome. Complement Ther Med. 2014; 22(4): 640-4[DOI]
  • 12. Fiedorowicz M, Makarewicz D, Stanczak-Mrozek KI, Grieb P. CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia. Acta Neurobiol Exp (Wars). 2008; 68(3): 389-97[PubMed]
  • 13. Ozer EA, Yilmaz O, Akhisaroglu M, Tuna B, Bakiler AR, Ozer E. Heat shock protein 70 expression in neonatal rats after hypoxic stress. J Matern Fetal Neonatal Med. 2002; 12(2): 112-7[DOI][PubMed]
  • 14. Jiang KW, Yang CW, Shui QX, Xia ZZ, Zhang Y. [Time-course of mu-calpain activation, c-Fos, c-Jun, HSP70 and HSP27 expression in hypoxic-ischemic neonatal rat brain]. Zhonghua Er Ke Za Zhi. 2004; 42(6): 441-5[PubMed]
  • 15. Child DF, Hudson PR, Hunter-Lavin C, Mukhergee S, China S, Williams CP, Williams JH, et al. Birth defects and anti-heat shock protein 70 antibodies in early pregnancy. Cell Stress Chaperones. 2006; 11(1): 101-5[PubMed]
  • 16. Franklin TB, Krueger-Naug AM, Clarke DB, Arrigo AP, Currie RW. The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system. Int J Hyperthermia. 2005; 21(5): 379-92[DOI][PubMed]
  • 17. Nakasono I. [Application of immunohistochemistry for forensic pathological diagnosis: finding of human brain in forensic autopsy]. Nihon Hoigaku Zasshi. 2001; 55(3): 299-309[PubMed]
  • 18. Nguyen TT, Zlacka D, Vavrincova P, Sedlacek P, Hromadnikova I. Detection of antibodies against 60-, 65- and 70-kDa heat shock proteins in paediatric patients with various disorders using Western blotting and ELISA. Clin Chem Lab Med. 2006; 44(4): 442-9[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments