Iranian Journal of Pediatrics

Published by: Kowsar

The Effects of Nutrition, Exercise, and a Praying Program on Reducing Iron Overload in Patients With Beta-Thalassemia Major: A Randomized Clinical Trial

Zahra Molazem 1 , * , Roghaye Noormohammadi 2 , Roya Dokouhaki 3 , Maryam Zakerinia 4 and Zahra Bagheri 5
Authors Information
1 Community Based Nursing and Midwifery Research Center, Faculty of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Nursing, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Internal Medicine, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
5 Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Iranian Journal of Pediatrics: October 2016, 26 (5); e3869
  • Published Online: June 1, 2016
  • Article Type: Research Article
  • Received: August 17, 2015
  • Revised: April 20, 2016
  • Accepted: May 8, 2016
  • DOI: 10.5812/ijp.3869

To Cite: Molazem Z, Noormohammadi R, Dokouhaki R, Zakerinia M, Bagheri Z. The Effects of Nutrition, Exercise, and a Praying Program on Reducing Iron Overload in Patients With Beta-Thalassemia Major: A Randomized Clinical Trial, Iran J Pediatr. 2016 ; 26(5):e3869. doi: 10.5812/ijp.3869.

Copyright © 2016, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Muncie HJ, Campbell J. Alpha and beta thalassemia. Am Fam Physician. 2009; 80(4): 339-44[PubMed]
  • 2. Heidary H, Bijeh N, Javahery SAAH, Abrishami F. The effect of eight weeks of aerobic training on hematological indices in β-thalassemia minor patients in kermanshah. Horiz Med Sci. 2011; 17(3): 20-8
  • 3. Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010; 5: 11[DOI][PubMed]
  • 4. Kohgo Y, Ikuta K, Ohtake T, Torimoto Y, Kato J. Body iron metabolism and pathophysiology of iron overload. Int J Hematol. 2008; 88(1): 7-15[DOI][PubMed]
  • 5. Patel HV, Qari M, Mousa SA, Bloemen S, Laat BD, Hemker HC, et al. Iron balance in β-thalassemia: Maintaining an antioxidant/oxidant ratio. J Appl Hematol. 2012; 3(1): 4
  • 6. Gujja P, Rosing DR, Tripodi DJ, Shizukuda Y. Iron overload cardiomyopathy: better understanding of an increasing disorder. J Am Coll Cardiol. 2010; 56(13): 1001-12[DOI][PubMed]
  • 7. Waseem F, Khemomal KA, Sajid R. Antioxidant status in beta thalassemia major: a single-center study. Indian J Pathol Microbiol. 2011; 54(4): 761-3[DOI][PubMed]
  • 8. Claster S, Wood JC, Noetzli L, Carson SM, Hofstra TC, Khanna R, et al. Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. Am J Hematol. 2009; 84(6): 344-8[DOI][PubMed]
  • 9. Fung EB. Nutritional deficiencies in patients with thalassemia. Ann N Y Acad Sci. 2010; 1202: 188-96[DOI][PubMed]
  • 10. Lee JW. Iron chelation therapy in the myelodysplastic syndromes and aplastic anemia: a review of experience in South Korea. Int J Hematol. 2008; 88(1): 16-23[DOI][PubMed]
  • 11. Marsella M, Pepe A, Borgna-Pignatti C. Better survival and less cardiac morbidity in female patients with thalassemia major: a review of the literature. Ann N Y Acad Sci. 2010; 1202: 129-33[DOI][PubMed]
  • 12. Wang Y, Wu M, Al-Rousan R, Liu H, Fannin J, Paturi S, et al. Iron-induced cardiac damage: role of apoptosis and deferasirox intervention. J Pharmacol Exp Ther. 2011; 336(1): 56-63[DOI][PubMed]
  • 13. Britton RS, Leicester KL, Bacon BR. Iron toxicity and chelation therapy. Int J Hematol. 2002; 76(3): 219-28[PubMed]
  • 14. Yang LP, Keam SJ, Keating GM. Deferasirox : a review of its use in the management of transfusional chronic iron overload. Drugs. 2007; 67(15): 2211-30[PubMed]
  • 15. Schumacher YO, Schmid A, Konig D, Berg A. Effects of exercise on soluble transferrin receptor and other variables of the iron status. Br J Sports Med. 2002; 36(3): 195-9[PubMed]
  • 16. Vashtani SH, Nazem F, Bordar F. The effect of aerobic rehabilitation program on concentration of ferritin, iron, TIBC and cardiovascular operation in the young patients suffering from major thalassemia. J Guilan Univ Med Sci. 2009; 18(71): 95-102
  • 17. Rashidi M, Aboomardani M, Rafraf M, Arefhosseini SR, Keshtkar A, Joshaghani H. Effects of Vitamin E and Zinc Supplementation on Antioxidants in Beta thalassemia major Patients. Iran J Pediatr. 2011; 21(1): 8-14[PubMed]
  • 18. Mishra AK, Tiwari A. Iron overload in Beta thalassaemia major and intermedia patients. Maedica (Buchar). 2013; 8(4): 328-32[PubMed]
  • 19. Cappellini MD, Cohen A, Eleftheriou A, Piga A, Porter J, Taher A. Guidelines for the Clinical Management of Thalassaemia. 2008; [PubMed]
  • 20. Hawkins RC. Total iron binding capacity or transferrin concentration alone outperforms iron and saturation indices in predicting iron deficiency. Clin Chim Acta. 2007; 380(1-2): 203-7[DOI][PubMed]
  • 21. Jordan J, Kiernan W, Merker HJ, Wenzel M, Beneke R. Red cell membrane skeletal changes in marathon runners. Int J Sports Med. 1998; 19(1): 16-9[DOI][PubMed]
  • 22. Ji JZ, Meng QH. Evaluation of the interference of hemoglobin, bilirubin, and lipids on Roche Cobas 6000 assays. Clin Chim Acta. 2011; 412(17-18): 1550-3[DOI][PubMed]
  • 23. Wish JB. Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol. 2006; 1 Suppl 1-8[DOI][PubMed]
  • 24. Ito S, Ikuta K, Kato D, Shibusa K, Niizeki N, Tanaka H, et al. Non-transferrin-bound iron assay system utilizing a conventional automated analyzer. Clin Chim Acta. 2014; 437: 129-35[DOI][PubMed]
  • 25. Brissot P, Ropert M, Le Lan C, Loreal O. Non-transferrin bound iron: a key role in iron overload and iron toxicity. Biochim Biophys Acta. 2012; 1820(3): 403-10[DOI][PubMed]
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