Iranian Journal of Pediatrics

Published by: Kowsar

Oxidative Status in Epileptic Children Using Carbamazepine

Murat Tutanc 1 , Mustafa Aras 2 , Recep Dokuyucu 3 , * , Murat Altas 2 , Cem Zeren 4 , Vefik Arica 1 , Oktay Hasan Ozturk 5 , Sedat Motor 6 and Cahide Yilmaz 1
Authors Information
1 Department of Pediatrics, Mustafa Kemal University, Antakya, Hatay, Turkey
2 Department of Neurosurgery, Mustafa Kemal University, Antakya, Hatay, Turkey
3 Department of Physiology, Mustafa Kemal University, Antakya, Hatay, Turkey
4 Department of Forensic Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey
5 Department of Biochemistry, Akdeniz University, Antalya, Turkey
6 Department of Biochemistry, Mustafa Kemal University, Antakya, Hatay, Turkey
Article information
  • Iranian Journal of Pediatrics: December 28, 2015, 25 (6); e3885
  • Published Online: December 23, 2015
  • Article Type: Research Article
  • Received: August 20, 2015
  • Accepted: August 28, 2015
  • DOI: 10.5812/ijp.3885

To Cite: Tutanc M, Aras M, Dokuyucu R, Altas M, Zeren C, et al. Oxidative Status in Epileptic Children Using Carbamazepine, Iran J Pediatr. 2015 ; 25(6):e3885. doi: 10.5812/ijp.3885.

Abstract
Copyright © 2015, Growth & Development Research Center.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Footnote
References
  • 1. Carbamazepine In Childhood Epilepsy. The World Health Organization. Report prepared for the World Health Organization. 2006;
  • 2. Guideline SNC. Diagnosis and Management of Epilepsies in Children and Young People, in Scottish National Clinical Guideline. 2005;
  • 3. Yalçin A, Onaran İ, Yalçin A. Effect of antiepileptic drugs on erythrocyte osmotic fragility and lipid peroxidation. Epilepsy Res. 1994; 19(3): 249-52[DOI]
  • 4. Bast A, Haenen GR, Doelman CJ. Oxidants and antioxidants: State of the art. Am J Med. 1991; 91(3)[DOI]
  • 5. Arroyo S, de la Morena A. Life-threatening adverse events of antiepileptic drugs. Epilepsy Res. 2001; 47(1-2): 155-74[DOI]
  • 6. Del Maestro RF. An approach to free radicals in medicine and biology. Acta Physiol Scand Suppl. 1980; 492: 153-68[PubMed]
  • 7. Jesberger JA, Richardson JS. Oxygen Free Radicals and Brain Dysfunction. Int J Neurosci. 1991; 57(1-2): 1-17[DOI]
  • 8. Ramaekers VT, Bosman B, Jansen GA, Wanders RJ. Increased plasma malondialdehyde associated with cerebellar structural defects. Arch Dis Child. 1997; 77(3): 231-4[PubMed]
  • 9. Potrebic O, Jovic-Stosic J, Vucinic S, Tadic J, Radulac M. [Acute glyphosate-surfactant poisoning with neurological sequels and fatal outcome]. Vojnosanit Pregl. 2009; 66(9): 758-62[PubMed]
  • 10. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004; 37(4): 277-85[DOI][PubMed]
  • 11. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 38(12): 1103-11[DOI][PubMed]
  • 12. McCord JM. The evolution of free radicals and oxidative stress. Am J Med. 2000; 108(8): 652-9[DOI]
  • 13. Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radical Biol Med. 2000; 29(11): 1106-14[DOI]
  • 14. Kosecik M, Erel O, Sevinc E, Selek S. Increased oxidative stress in children exposed to passive smoking. Int J Cardiol. 2005; 100(1): 61-4[DOI][PubMed]
  • 15. Kawachi I, Colditz GA, Speizer FE, Manson JE, Stampfer MJ, Willett WC, et al. A prospective study of passive smoking and coronary heart disease. Circulation. 1997; 95(10): 2374-9[PubMed]
  • 16. Cengiz M, Yuksel A, Seven M. The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children. Pharmacol Res. 2000; 41(4): 423-5[DOI][PubMed]
  • 17. Gupta M, Gupta YK, Agarwal S, Aneja S, Kalaivani M, Kohli K. Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsia. 2004; 45(12): 1636-9[DOI][PubMed]
  • 18. Isik M, Demir Y, Kirici M, Demir R, Simsek F, Beydemir S. Changes in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs. Arch Physiol Biochem. 2015; 121(3): 97-102[DOI][PubMed]
  • 19. Naziroglu M, Yurekli VA. Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements. Cell Mol Neurobiol. 2013; 33(5): 589-99[DOI][PubMed]
  • 20. Stockis A, Chanteux H, Rosa M, Rolan P. Brivaracetam and carbamazepine interaction in healthy subjects and in vitro. Epilepsy Res. 2015; 113: 19-27[DOI][PubMed]
  • 21. Li ZH, Li P, Rodina M, Randak T. Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa. Chemosphere. 2010; 80(5): 530-4[DOI][PubMed]
  • 22. Li ZH, Zlabek V, Velisek J, Grabic R, Machova J, Randak T. Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment. Comp Biochem Physiol C Toxicol Pharmacol. 2010; 151(1): 137-41[DOI][PubMed]
  • 23. Chang SJ, Yu BC. Mitochondrial matters of the brain: mitochondrial dysfunction and oxidative status in epilepsy. J Bioenerg Biomembr. 2010; 42(6): 457-9[DOI][PubMed]
  • 24. Liang LP, Patel M. Seizure-induced changes in mitochondrial redox status. Free Radic Biol Med. 2006; 40(2): 316-22[DOI][PubMed]
  • 25. Bruce AJ, Baudry M. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radical Biol Med. 1995; 18(6): 993-1002[DOI]
  • 26. Gluck MR, Jayatilleke E, Shaw S, Rowan AJ, Haroutunian V. CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy. Epilepsy Res. 2000; 39(1): 63-71[DOI]
  • 27. Willmore LJ, Rubin JJ. Antiperoxidant pretreatment and iron-induced epileptiforom discharges in the rat: EEG and histopathologic studies. Neurology. 1981; 31(1): 63[DOI]
  • 28. Hamed S, Abdellah MM. Trace Elements and Electrolytes Homeostasis and Their Relation to Antioxidant Enzyme Activity in Brain Hyperexcitability of Epileptic Patients. J Pharmacol Sci. 2004; 96(4): 349-59[DOI]
  • 29. Solowiej E, Sobaniec W. [The effect of antiepileptic drug therapy on antioxidant enzyme activity and serum lipid peroxidation in young patients with epilepsy]. Neurol Neurochir Pol. 2003; 37(5): 991-1003[PubMed]
  • 30. Niketic V, Ristic S, Saicic ZS, Spasic M, Buzadzic B, Stojkovic M. Activities of antioxidant enzymes and formation of the glutathione adduct of hemoglobin (Hb ASSG) in epileptic patients with long-term antiepileptic therapy. Farmaco. 1995; 50(11): 811-3[PubMed]
  • 31. Mahle C, Dasgupta A. Decreased total antioxidant capacity and elevated lipid hydroperoxide concentrations in sera of epileptic patients receiving phenytoin. Life Sci. 1997; 61(4): 437-43[DOI]
  • 32. Peker E, Oktar S, Ari M, Kozan R, Dogan M, Cagan E, et al. Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid. Brain Res. 2009; 1297: 194-7[DOI][PubMed]
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