Iranian Journal of Pediatrics

Published by: Kowsar

Flixweed vs. Polyethylene Glycol in the Treatment of Childhood Functional Constipation: A Randomized Clinical Trial

Majid Nimrouzi 1 , 2 , * , Omid Sadeghpour 1 , Mohammad Hadi Imanieh 2 , Mohammadreza Shams Ardekani 3 , Alireza Salehi 3 , Mohamad Bagher Minaei 4 and Mohammad M. Zarshenas 5 , 6
Authors Information
1 Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, IR Iran
2 Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran
4 School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
5 Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran
6 Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Iranian Journal of Pediatrics: April 28, 2015, 25 (2)
  • Published Online: April 18, 2015
  • Article Type: Research Article
  • Received: February 5, 2015
  • Revised: February 13, 2015
  • Accepted: March 10, 2015
  • DOI: 10.5812/ijp.425

To Cite: Nimrouzi M, Sadeghpour O, Imanieh M H, Shams Ardekani M, Salehi A, et al. Flixweed vs. Polyethylene Glycol in the Treatment of Childhood Functional Constipation: A Randomized Clinical Trial, Iran J Pediatr. 2015 ; 25(2):-. doi: 10.5812/ijp.425.

Copyright © 2015, Growth & Development Research Center.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Gray JR. What is chronic constipation? Definition and diagnosis. Can J Gastroenterol. 2011; 25 Suppl B: 7B-10B[PubMed]
  • 2. Ansari R, Sohrabi MR, Roohi S, Mikaeli J, Massarrat S, Tahaghoghi Mehrizi S, et al. Colonic Transit Time In 64 Iranian Patients With Idiopathic Chronic Constipation. Arch Iran Med. 2001; 4(1): 6
  • 3. Izadi M, Mansour-Ghanaei F, Jafarshad R, Joukar F, Bagherzadeh AH, Tareh F. Clinical Manifestations of Hirschsprung’ s Disease: A Six Year Course Review of Admitted Patients in Gilan, Northern Iran. Middle East J Digest Dis. 2009; 1(2): 68-73
  • 4. Baker SS, Liptak GS, Colletti RB, Croffie JM, Di Lorenzo C, Ector W, et al. Constipation in infants and children: evaluation and treatment. A medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1999; 29(5): 612-26[PubMed]
  • 5. Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther. 2010; 31(9): 938-49[DOI][PubMed]
  • 6. Inan M, Aydiner CY, Tokuc B, Aksu B, Ayvaz S, Ayhan S, et al. Factors associated with childhood constipation. J Paediatr Child Health. 2007; 43(10): 700-6[DOI][PubMed]
  • 7. Rajindrajith S, Devanarayana NM. Constipation in children: diagnosis and management. Sri Lanka J Child Health. 2009; 38(4): 127-35[DOI]
  • 8. Afzal NA, Tighe MP, Thomson MA. Constipation in children. Ital J Pediatr. 2011; 37: 28[DOI][PubMed]
  • 9. Quitadamo P, Coccorullo P, Giannetti E, Romano C, Chiaro A, Campanozzi A, et al. A randomized, prospective, comparison study of a mixture of acacia fiber, psyllium fiber, and fructose vs polyethylene glycol 3350 with electrolytes for the treatment of chronic functional constipation in childhood. J Pediatr. 2012; 161(4): 710-5 e1[DOI][PubMed]
  • 10. Bae SH. Long-term safety of PEG 4000 in children with chronic functional constipation: A biochemical perspective. Korean J Pediatr. 2010; 53(7): 741-4[DOI][PubMed]
  • 11. Li J, Liu X, Dong F, Xu J, Zheng Y, Shan W. Determination of the volatile composition in essential oil of Descurainia sophia (L.) Webb ex Prantl (Flixweed) by gas chromatography/mass spectrometry (GC/MS). Molecules. 2010; 15(1): 233-40[DOI][PubMed]
  • 12. Lee YJ, Kim NS, Kim H, Yi JM, Oh SM, Bang OS, et al. Cytotoxic and anti-inflammatory constituents from the seeds of Descurainia sophia. Arch Pharm Res. 2013; 36(5): 536-41[DOI][PubMed]
  • 13. Mohamed NH, Mahrous AE. Chemical constituents of Descurainia sophia L. and its biological activity. Rec Nat Proc. 2009; 3(1): 58-67
  • 14. Pasalar M, Bagheri Lankarani K, Mehrabani D, Tolide H. The effect of Descureania Sophia L. and Prunus Domestica L. in prevention of constipation among Iranian Hajj Pilgrims, Saudi Arabia. Res J Pharmaceut Biol Chem Sci. 2013; 4(2): 1195-204
  • 15. Sun K, Li X, Li W, Wang J, Liu J, Sha Y. Two new lactones and one new aryl-8-oxa-bicyclo[3,2,1]oct-3-en-2-one from Descurainia sophia. Chem Pharm Bull (Tokyo). 2004; 52(12): 1483-6[PubMed]
  • 16. Drossman DA, Dumitrascu DL. Rome III: New standard for functional gastrointestinal disorders. J Gastrointestin Liver Dis. 2006; 15(3): 237-41[PubMed]
  • 17. Nurko S, Youssef NN, Sabri M, Langseder A, McGowan J, Cleveland M, et al. PEG3350 in the treatment of childhood constipation: a multicenter, double-blinded, placebo-controlled trial. J Pediatr. 2008; 153(2): 254-61[DOI][PubMed]
  • 18. Avicenna H. Ghanoon Dar Teb [The Canon of Medicine], Bulaq Edition. 1978; 345[DOI]
  • 19. Sun K, Li X, Liu JM, Wang JH, Li W, Sha Y. A novel sulphur glycoside from the seeds of Descurainia sophia (L.). J Asian Nat Prod Res. 2005; 7(6): 853-6[DOI][PubMed]
  • 20. Karami H, Khademloo M, Niari P. Polyethylene glycol versus paraffin for the treatment of childhood functional constipation. Iran J Pediatr. 2009; 19(3): 255-61
  • 21. Wang Y, Wang B, Jiang X, Jiang M, Xu C, Shao C, et al. Polyethylene glycol 4000 treatment for children with constipation: A randomized comparative multicenter study. Exp Ther Med. 2012; 3(5): 853-6[DOI][PubMed]
  • 22. Lee-Robichaud H, Thomas K, Morgan J, Nelson RL. Lactulose versus Polyethylene Glycol for Chronic Constipation. Cochrane Database Syst Rev. 2010; (7)[DOI][PubMed]
  • 23. Bekkali NL, van den Berg MM, Dijkgraaf MG, van Wijk MP, Bongers ME, Liem O, et al. Rectal fecal impaction treatment in childhood constipation: enemas versus high doses oral PEG. Pediatrics. 2009; 124(6)-15[DOI][PubMed]
  • 24. Savino F, Viola S, Erasmo M, Di Nardo G, Oliva S, Cucchiara S. Efficacy and tolerability of peg-only laxative on faecal impaction and chronic constipation in children. A controlled double blind randomized study vs a standard peg-electrolyte laxative. BMC Pediatr. 2012; 12: 178[DOI][PubMed]
  • 25. Pijpers MA, Bongers ME, Benninga MA, Berger MY. Functional constipation in children: a systematic review on prognosis and predictive factors. J Pediatr Gastroenterol Nutr. 2010; 50(3): 256-68[DOI][PubMed]
  • 26. Kelishadi R, Haghdoost AA, Sadeghirad B, Khajehkazemi R. Trend in the prevalence of obesity and overweight among Iranian children and adolescents: a systematic review and meta-analysis. Nutrition. 2014; 30(4): 393-400[DOI][PubMed]
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