Iranian Journal of Pediatrics

Published by: Kowsar

Investigation of H19/RsaI Polymorphism in Children With Low Birth Weight in Pernambuco, Brazil

Paula Maia 1 , 2 , Paulo Souza 3 , Hildson Dornelas Angelo 4 , 5 , Igor Santos 3 , Danyelly Martins 6 , Jose Lima Filho 6 and Maria Mascena Maia 3 , *
Authors Information
1 Federal University of Vale do Sao Francisco, Petrolina, Brazil
2 Dom Malan Hospital, Petrolina- Pernambuco, Brazil
3 Department of Biology, Federal Rural University of Pernambuco, Recife-Pernambuco, Brazil
4 Federal Institute of Pernambuco, Campus Garanhuns, Garanhuns- Pernambuco, Brazil
5 Post-Graduated Program in Genetics, Federal University of Pernambuco Recife- Pernambuco, Recife, Brazil
6 Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife-Pernambuco, Brazil
Article information
  • Iranian Journal of Pediatrics: April 28, 2015, 25 (2)
  • Published Online: April 18, 2015
  • Article Type: Research Article
  • Received: February 14, 2014
  • Accepted: January 17, 2015
  • DOI: 10.5812/ijp.461

To Cite: Maia P, Souza P, Angelo H D, Santos I, Martins D, et al. Investigation of H19/RsaI Polymorphism in Children With Low Birth Weight in Pernambuco, Brazil, Iran J Pediatr. 2015 ; 25(2):-. doi: 10.5812/ijp.461.

Copyright © 2015, Growth & Development Research Center.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Falcao MC. Avaliacao nutricional do recem-nascido. Pediatria. 2000; 22(3): 233-9
  • 2. Lee JE, Pintar J, Efstratiadis A. Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development. 1990; 110(1): 151-9[PubMed]
  • 3. Gabory A, Ripoche MA, Le Digarcher A, Watrin F, Ziyyat A, Forne T, et al. H19 acts as a trans regulator of the imprinted gene network controlling growth in mice. Development. 2009; 136(20): 3413-21[DOI][PubMed]
  • 4. Hao Y, Crenshaw T, Moulton T, Newcomb E, Tycko B. Tumour-suppressor activity of H19 RNA. Nature. 1993; 365(6448): 764-7[DOI][PubMed]
  • 5. Li YM, Franklin G, Cui HM, Svensson K, He XB, Adam G, et al. The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans. J Biol Chem. 1998; 273(43): 28247-52[PubMed]
  • 6. Faienza MF, Santoro N, Lauciello R, Calabro R, Giordani L, Di Salvo G, et al. IGF2 gene variants and risk of hypertension in obese children and adolescents. Pediatr Res. 2010; 67(4): 340-4[DOI][PubMed]
  • 7. Banet G, Bibi O, Matouk I, Ayesh S, Laster M, Kimber KM, et al. Characterization of human and mouse H19 regulatory sequences. Mol Biol Rep. 2000; 27(3): 157-65[PubMed]
  • 8. Petry CJ, Ong KK, Barratt BJ, Wingate D, Cordell HJ, Ring SM, et al. Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genet. 2005; 6: 22[DOI][PubMed]
  • 9. Leighton PA, Ingram RS, Eggenschwiler J, Efstratiadis A, Tilghman SM. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature. 1995; 375(6526): 34-9[DOI][PubMed]
  • 10. Araujo FM. Ocorrencia Familial e Associacao de Polimorfismos dos Genes H19 e IGF2 com as Síndromes Hipertensivas Gestacionais 118f.
  • 11. de Mascena Diniz Maia PF, da Silva TM, Angelo HD, e Silva LW, Gondim Martins DB, de Mascena Diniz Maia M, et al. IGF2/ApaI polymorphism associated with birth weight in children of the region of Petrolina-PE, Brazil. J Matern Fetal Neonatal Med. 2013; 26(3): 316-7[DOI][PubMed]
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