Iranian Journal of Pediatrics

Published by: Kowsar

Vitamin B12 < 300 pg/mL in Children and Especially Adolescents May Predispose Forgetfulness, Anxiety, and Unhappiness

Selcen Yaroglu Kazanci 1 , * , Neslihan Ozkul Saglam 1 and Rahma Houssein Omar 1
Authors Information
1 Department of Pediatrics, Division of General Pediatrics, Bakırkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey
Article information
  • Iranian Journal of Pediatrics: August 2017, 27 (4); e4663
  • Published Online: August 14, 2016
  • Article Type: Research Article
  • Received: November 9, 2015
  • Revised: June 29, 2016
  • Accepted: July 22, 2016
  • DOI: 10.5812/ijp.4663

To Cite: Kazanci S Y, Saglam N O, Omar R H. Vitamin B12 < 300 pg/mL in Children and Especially Adolescents May Predispose Forgetfulness, Anxiety, and Unhappiness, Iran J Pediatr. 2017 ; 27(4):e4663. doi: 10.5812/ijp.4663.

Copyright © 2016, Growth &amp; Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Patıroglu, T. , Ozdemir, M. A. , Hasanoglu, E. . İlkokul cocuklarında anemi taraması [Turkish]. Cocuk Sag Hast Derg. 1987; 30(4): 315-9
  • 2. Isik Balci Y, Karabulut A, Gurses D, Ethem Covut I. Prevalence and Risk Factors of Anemia among Adolescents in Denizli, Turkey. Iran J Pediatr. 2012; 22(1): 77-81[PubMed]
  • 3. Baytan B, Ozdemir O, Erdemir G, Gunes, A. M. . Cocukluk cagında vitamin B12 eksikligi klinik bulgular ve tedavi. Uludağ Univ Tıp Fak Derg. 2007; 33(2): 61-4
  • 4. Taneja S, Bhandari N, Strand TA, Sommerfelt H, Refsum H, Ueland PM, et al. Cobalamin and folate status in infants and young children in a low-to-middle income community in India. Am J Clin Nutr. 2007; 86(5): 1302-9[PubMed]
  • 5. Dong C, Ge P, Ren X, Zhao X, Wang J, Fan H, et al. The micronutrient status of children aged 24-60 months living in rural disaster areas one year after the Wenchuan Earthquake. PLoS One. 2014; 9(2): 88444[DOI][PubMed]
  • 6. Onal H, Adal E, Oner T. Gelismekte olan ulkelerde önemli bir sorun: annede ve yenidoganda B12 vitamini eksikligi [Turkish]. Turk Ped Ars. 2010; 45(3): 242-5
  • 7. Rosales FJ, Reznick JS, Zeisel SH. Understanding the role of nutrition in the brain and behavioral development of toddlers and preschool children: identifying and addressing methodological barriers. Nutr Neurosci. 2009; 12(5): 190-202[DOI][PubMed]
  • 8. Benton D. The influence of dietary status on the cognitive performance of children. Mol Nutr Food Res. 2010; 54(4): 457-70[DOI][PubMed]
  • 9. Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull. 2008; 29(2 Suppl): 126-31[PubMed]
  • 10. Sachdev PS, Parslow RA, Lux O, Salonikas C, Wen W, Naidoo D, et al. Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychol Med. 2005; 35(4): 529-38[PubMed]
  • 11. Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 2005; 19(1): 59-65[DOI][PubMed]
  • 12. Georgieff MK. Nutrition and the developing brain: nutrient priorities and measurement. Am J Clin Nutr. 2007; 85(2): 612-20[PubMed]
  • 13. Lampkin BC, Saunders EF. Nutritional vitamin B12 deficiency in an infant. J Pediatr. 1969; 75(6): 1053-5[PubMed]
  • 14. Garewal G, Narang A, Das KC. Infantile tremor syndrome: a vitamin B12 deficiency syndrome in infants. J Trop Pediatr. 1988; 34(4): 174-8[PubMed]
  • 15. Siddiqui AH, Ansari A, Beech CM, Shah NP, Tanner SM, Sarnaik SA. Juvenile cobalamin deficiency in a 17-year-old child with autonomic dysfunction and skin changes. J Pediatr Hematol Oncol. 2012; 34(2): 140-2[DOI][PubMed]
  • 16. Incecik F, Herguner MO, Altunbasak S, Leblebisatan G. Neurologic findings of nutritional vitamin B12 deficiency in children. Turk J Pediatr. 2010; 52(1): 17-21[PubMed]
  • 17. Grober U, Kisters K, Schmidt J. Neuroenhancement with vitamin B12-underestimated neurological significance. Nutrients. 2013; 5(12): 5031-45[DOI][PubMed]
  • 18. Song SM, Bae KW, Yoon HS, Im HJ, Seo JJ. A case of anemia caused by combined vitamin B12 and iron deficiency manifesting as short stature and delayed puberty. Korean J Pediatr. 2010; 53(5): 661-5[DOI][PubMed]
  • 19. Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency--an update. Haematologica. 2006; 91(11): 1506-12[PubMed]
  • 20. Bolaman Z, Kadıkoyle, G. , Yukselen, V. , Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center prospective randomized open-label study. Clin Ther. 2003; 25(12): 3124-34[DOI]
  • 21. Carmel R. How I treat cobalamin (vitamin B12) deficiency. Blood. 2008; 112(6): 2214-21[DOI][PubMed]
  • 22. Green R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am J Clin Nutr. 2011; 94(2): 666-72[DOI][PubMed]
  • 23. AydoGdu Colak, A. , Anil, M. , Toprak, B. . B12 vitamin level in children and its relationship with complete blood count parameters. Behc Uz Coc Hast Derg. 2012; 2(2): 75-9[DOI]
  • 24. Elete itKoc A, Kocyigit, A. , Ulukanlıgil, M. , Demir, N. . Sanlıurfa yoresinde 9-12 yas grubu cocuklarda B12 vitamini ve folik asit eksikligi sıklıgı ile bagırsak solucanlarıyla iliskisi[Turkish]. Cocuk Sag Hast Derg. 2005; 48(4): 308-15
  • 25. Iglesia I, Mouratidou T, Gonzalez-Gross M, Huybrechts I, Breidenassel C, Santabarbara J, et al. Foods contributing to vitamin B6, folate, and vitamin B12 intakes and biomarkers status in European adolescents: The HELENA study. Eur J Nutr. 2016; [DOI][PubMed]
  • 26. Gupta Bansal P, Singh Toteja G, Bhatia N, Kishore Vikram N, Siddhu A, Kumar Garg A, et al. Deficiencies of Serum Ferritin and Vitamin B12, but not Folate, are Common in Adolescent Girls Residing in a Slum in Delhi. Int J Vitam Nutr Res. 2015; 85(1-2): 14-22[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments