Iranian Journal of Pediatrics

Published by: Kowsar

Expression and Role of CD166 in the Chronic Kidney Disease

Yan Sun 1 , * , Yiping Wang 2 , Qi Cao 2 , Hong Yu 3 , Dong Zheng 2 , Ya Wang 2 and David C. H. Harris 2
Authors Information
1 Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
2 Centre for Transplantation and Renal Research, University of Sydney at Westmead Millennium Institute, Sydney, Australia
3 The High Tech Centre, Westmead Millennium Institute, University of Sydney Westmead, Sydney, Australia
Article information
  • Iranian Journal of Pediatrics: October 28, 2015, 25 (5); e543
  • Published Online: October 6, 2015
  • Article Type: Research Article
  • Received: February 5, 2015
  • Accepted: February 16, 2015
  • DOI: 10.5812/ijp.543

To Cite: Sun Y, Wang Y, Cao Q, Yu H, Zheng D, et al. Expression and Role of CD166 in the Chronic Kidney Disease, Iran J Pediatr. 2015 ; 25(5):e543. doi: 10.5812/ijp.543.

Copyright © 2015, Growth & Development Research Center.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Gimferrer I, Calvo M, Mittelbrunn M, Farnos M, Sarrias MR, Enrich C, et al. Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol. 2004; 173(4): 2262-70[PubMed]
  • 2. Ibanez A, Sarrias MR, Farnos M, Gimferrer I, Serra-Pages C, Vives J, et al. Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor. J Immunol. 2006; 177(2): 1152-9[PubMed]
  • 3. Swart GW. Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. Eur J Cell Biol. 2002; 81(6): 313-21[DOI][PubMed]
  • 4. Ohneda O, Ohneda K, Arai F, Lee J, Miyamoto T, Fukushima Y, et al. ALCAM (CD166): its role in hematopoietic and endothelial development. Blood. 2001; 98(7): 2134-42[PubMed]
  • 5. Jezierska A, Matysiak W, Motyl T. ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. Med Sci Monit. 2006; 12(8)-73[PubMed]
  • 6. Ofori-Acquah SF, King JA. Activated leukocyte cell adhesion molecule: a new paradox in cancer. Transl Res. 2008; 151(3): 122-8[DOI][PubMed]
  • 7. van Kempen LC, van den Oord JJ, van Muijen GN, Weidle UH, Bloemers HP, Swart GW. Activated leukocyte cell adhesion molecule/CD166, a marker of tumor progression in primary malignant melanoma of the skin. Am J Pathol. 2000; 156(3): 769-74[DOI][PubMed]
  • 8. Masedunskas A, King JA, Tan F, Cochran R, Stevens T, Sviridov D, et al. Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration. FEBS Lett. 2006; 580(11): 2637-45[DOI][PubMed]
  • 9. Ikezumi Y, Kanno K, Karasawa T, Han GD, Ito Y, Koike H, et al. The role of lymphocytes in the experimental progressive glomerulonephritis. Kidney Int. 2004; 66(3): 1036-48[DOI][PubMed]
  • 10. Segerer S, Djafarzadeh R, Grone HJ, Weingart C, Kerjaschki D, Weber C, et al. Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammation. J Am Soc Nephrol. 2007; 18(6): 1835-44[DOI][PubMed]
  • 11. Ruster C, Wolf G. The role of chemokines and chemokine receptors in diabetic nephropathy. Front Biosci. 2008; 13: 944-55[PubMed]
  • 12. Aggelis V, Craven RA, Peng J, Harnden P, Cairns DA, Maher ER, et al. Proteomic identification of differentially expressed plasma membrane proteins in renal cell carcinoma by stable isotope labelling of a von Hippel-Lindau transfectant cell line model. Proteomics. 2009; 9(8): 2118-30[DOI][PubMed]
  • 13. Roemeling-van Rhijn M, Reinders ME, de Klein A, Douben H, Korevaar SS, Mensah FK, et al. Mesenchymal stem cells derived from adipose tissue are not affected by renal disease. Kidney Int. 2012; 82(7): 748-58[DOI][PubMed]
  • 14. Cao Q, Wang Y, Zheng D, Sun Y, Wang Y, Lee VW, et al. IL-10/TGF-beta-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis. J Am Soc Nephrol. 2010; 21(6): 933-42[DOI][PubMed]
  • 15. Cao Q, Wang Y, Zheng D, Sun Y, Wang C, Wang XM, et al. Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo. Kidney Int. 2014; 85(4): 794-806[DOI][PubMed]
  • 16. Chi V, Chandy KG. Immunohistochemistry: paraffin sections using the Vectastain ABC kit from vector labs. J Vis Exp. 2007; (8): 308[DOI][PubMed]
  • 17. Egwuagu CE, Yu CR, Zhang M, Mahdi RM, Kim SJ, Gery I. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J Immunol. 2002; 168(7): 3181-7[PubMed]
  • 18. Egwuagu CE, Sztein J, Mahdi RM, Li W, Chao-Chan C, Smith JA, et al. IFN-gamma increases the severity and accelerates the onset of experimental autoimmune uveitis in transgenic rats. J Immunol. 1999; 162(1): 510-7[PubMed]
  • 19. Suga T, Mitani A, Mogi M, Kikuchi T, Fujimura T, Takeda H, et al. Aggregatibacter actinomycetemcomitans lipopolysaccharide stimulated epithelial cells produce interleukin-15 that regulates T cell activation. Arch Oral Biol. 2013; 58(10): 1541-8[DOI][PubMed]
  • 20. Zoja C, Abbate M, Remuzzi G. Progression of chronic kidney disease: insights from animal models. Curr Opin Nephrol Hypertens. 2006; 15(3): 250-7[DOI][PubMed]
  • 21. Isome M, Fujinaka H, Adhikary LP, Kovalenko P, El-Shemi AG, Yoshida Y, et al. Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats. Nephrol Dial Transplant. 2004; 19(12): 2997-3004[DOI][PubMed]
  • 22. Kim SM, Kim HW. Relative lymphocyte count as a marker of progression of chronic kidney disease. Int Urol Nephrol. 2014; 46(7): 1395-401[DOI][PubMed]
  • 23. van Kempen LC, Nelissen JM, Degen WG, Torensma R, Weidle UH, Bloemers HP, et al. Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction. J Biol Chem. 2001; 276(28): 25783-90[DOI][PubMed]
  • 24. Gilsanz A, Sanchez-Martin L, Gutierrez-Lopez MD, Ovalle S, Machado-Pineda Y, Reyes R, et al. ALCAM/CD166 adhesive function is regulated by the tetraspanin CD9. Cell Mol Life Sci. 2013; 70(3): 475-93[DOI][PubMed]
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