Iranian Journal of Pediatrics

Published by: Kowsar

Detection of Early Right Ventricular Dysfunction in Young Patients With Thalassemia Major Using Tissue Doppler Imaging

Helen Bornaun 1 , * , Reyhan Dedeoglu 2 , Kazim Oztarhan 1 , Savas Dedeoglu 3 , Erkan Erfidan 4 , Muge Gundogdu 5 , Gonul Aydogan 5 and Dicle Cengiz 6
Authors Information
1 Department of Pediatric Cardiology, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
2 Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
3 Institute of Health Sciences, Uskudar University, Istanbul, Turkey
4 Department of Pediatrics, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
5 Department of Pediatric Hematology, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
6 Departments of Statistics, Istanbul Commerce University, Istanbul, Turkey
Article information
  • Iranian Journal of Pediatrics: June 2016, 26 (3); e5808
  • Published Online: May 18, 2016
  • Article Type: Research Article
  • Received: February 27, 2016
  • Revised: April 11, 2016
  • Accepted: April 30, 2016
  • DOI: 10.5812/ijp.5808

To Cite: Bornaun H, Dedeoglu R, Oztarhan K, Dedeoglu S, Erfidan E, et al. Detection of Early Right Ventricular Dysfunction in Young Patients With Thalassemia Major Using Tissue Doppler Imaging, Iran J Pediatr. 2016 ; 26(3):e5808. doi: 10.5812/ijp.5808.

Copyright © 2016, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Weatherall DJ, Clegg JB. The thalassaemia syndromes. 2008;
  • 2. Borgna-Pignatti C, Rugolotto S, De Stefano P, Piga A, Di Gregorio F, Gamberini MR, et al. Survival and disease complications in thalassemia major. Ann N Y Acad Sci. 1998; 850: 227-31[PubMed]
  • 3. Li CK, Luk CW, Ling SC, Chik KW, Yuen HL, Li CK, et al. Morbidity and mortality patterns of thalassaemia major patients in Hong Kong: retrospective study. Hong Kong Med J. 2002; 8(4): 255-60[PubMed]
  • 4. Modell B, Khan M, Darlison M, Westwood MA, Ingram D, Pennell DJ. Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2008; 10: 42[DOI][PubMed]
  • 5. Olivieri NF, Nathan DG, MacMillan JH, Wayne AS, Liu PP, McGee A, et al. Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med. 1994; 331(9): 574-8[DOI][PubMed]
  • 6. Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, et al. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009; 120(20): 1961-8[DOI][PubMed]
  • 7. Vogel M, Anderson LJ, Holden S, Deanfield JE, Pennell DJ, Walker JM. Tissue Doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload. Eur Heart J. 2003; 24(1): 113-9[PubMed]
  • 8. Hamdy AM. Use of strain and tissue velocity imaging for early detection of regional myocardial dysfunction in patients with beta thalassemia. Eur J Echocardiogr. 2007; 8(2): 102-9[DOI][PubMed]
  • 9. Magri D, Sciomer S, Fedele F, Gualdi G, Casciani E, Pugliese P, et al. Early impairment of myocardial function in young patients with beta-thalassemia major. Eur J Haematol. 2008; 80(6): 515-22[DOI][PubMed]
  • 10. Kremastinos DT, Tsetsos GA, Tsiapras DP, Karavolias GK, Ladis VA, Kattamis CA. Heart failure in beta thalassemia: a 5-year follow-up study. Am J Med. 2001; 111(5): 349-54[PubMed]
  • 11. Quinones MA, Otto CM, Stoddard M, Waggoner A, Zoghbi WA, Doppler Quantification Task Force of the N, et al. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr. 2002; 15(2): 167-84[PubMed]
  • 12. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989; 2(5): 358-67[PubMed]
  • 13. Miller D, Farah MG, Liner A, Fox K, Schluchter M, Hoit BD. The relation between quantitative right ventricular ejection fraction and indices of tricuspid annular motion and myocardial performance. J Am Soc Echocardiogr. 2004; 17(5): 443-7[DOI][PubMed]
  • 14. Eidem BW, McMahon CJ, Cohen RR, Wu J, Finkelshteyn I, Kovalchin JP, et al. Impact of cardiac growth on Doppler tissue imaging velocities: a study in healthy children. J Am Soc Echocardiogr. 2004; 17(3): 212-21[DOI][PubMed]
  • 15. Westwood M, Anderson LJ, Firmin DN, Gatehouse PD, Charrier CC, Wonke B, et al. A single breath-hold multiecho T2* cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload. J Magn Reson Imaging. 2003; 18(1): 33-9[DOI][PubMed]
  • 16. Wood JC. Impact of iron assessment by MRI. Hematology Am Soc Hematol Educ Program. 2011; 2011: 443-50[DOI][PubMed]
  • 17. Carpenter JP, He T, Kirk P, Roughton M, Anderson LJ, de Noronha SV, et al. On T2* magnetic resonance and cardiac iron. Circulation. 2011; 123(14): 1519-28[DOI][PubMed]
  • 18. Hahalis G, Manolis AS, Gerasimidou I, Alexopoulos D, Sitafidis G, Kourakli A, et al. Right ventricular diastolic function in beta-thalassemia major: echocardiographic and clinical correlates. Am Heart J. 2001; 141(3): 428-34[DOI][PubMed]
  • 19. Hahalis G, Manolis AS, Apostolopoulos D, Alexopoulos D, Vagenakis AG, Zoumbos NC. Right ventricular cardiomyopathy in beta-thalassaemia major. Eur Heart J. 2002; 23(2): 147-56[DOI][PubMed]
  • 20. Noori NM, Mehralizadeh S. Echocardiographic evaluation of systolic and diastolic heart function in patients suffering from beta-thalassemia major aged 5-10 years at the Zahedan Research Center for Children and Adolescent Health. Anadolu Kardiyol Derg. 2010; 10(2): 150-3[DOI][PubMed]
  • 21. Buja LM, Roberts WC. Iron in the heart. Etiology and clinical significance. Am J Med. 1971; 51(2): 209-21[PubMed]
  • 22. Kyriacou K, Michaelides Y, Senkus R, Simamonian K, Pavlides N, Antoniades L, et al. Ultrastructural pathology of the heart in patients with beta-thalassaemia major. Ultrastruct Pathol. 2000; 24(2): 75-81[PubMed]
  • 23. Louie EK, Lin SS, Reynertson SI, Brundage BH, Levitsky S, Rich S. Pressure and volume loading of the right ventricle have opposite effects on left ventricular ejection fraction. Circulation. 1995; 92(4): 819-24[PubMed]
  • 24. Barosi G, Arbustini E, Gavazzi A, Grasso M, Pucci A. Myocardial iron grading by endomyocardial biopsy. A clinico-pathologic study on iron overloaded patients. Eur J Haematol. 1989; 42(4): 382-8[PubMed]
  • 25. Saxena N, Rajagopalan N, Edelman K, Lopez-Candales A. Tricuspid annular systolic velocity: a useful measurement in determining right ventricular systolic function regardless of pulmonary artery pressures. Echocardiography. 2006; 23(9): 750-5[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments