Iranian Journal of Pediatrics

Published by: Kowsar

Evaluation of Classic Wiskott Aldrich Syndrome with Mild Symptoms in Two Cousins: A Case Report

Afshin Shirkani 1 and Shokrollah Farrokhi 1 , *
Authors Information
1 Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
Article information
  • Iranian Journal of Pediatrics: October 2017, 27 (5); e5883
  • Published Online: October 10, 2017
  • Article Type: Case Report
  • Received: March 6, 2016
  • Revised: June 23, 2017
  • Accepted: July 8, 2017
  • DOI: 10.5812/ijp.5883

To Cite: Shirkani A, Farrokhi S. Evaluation of Classic Wiskott Aldrich Syndrome with Mild Symptoms in Two Cousins: A Case Report, Iran J Pediatr. 2017 ; 27(5):e5883. doi: 10.5812/ijp.5883.

Copyright © 2017, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Zhu X, Tang B, Zheng C, Liu H, Song K, Sun Z. A novel mutation in Wiskott-Aldrich syndrome and successfully treated with umbilical cord blood transplantation. Blood Cells Mol Dis. 2014; 53(4): 283-5[DOI][PubMed]
  • 2. Yu H, Liu T, Meng W, Hou L. A novel WASP gene mutation in a Chinese boy with Wiskott-Aldrich syndrome. Int J Hematol. 2010; 92(2): 271-5[DOI][PubMed]
  • 3. Baharin MF, Kader Ibrahim SB, Yap SH, Abdul Manaf AM, Mat Ripen A, Dhaliwal JS. Molecular characterization of two Malaysian patients with Wiskott-Aldrich syndrome. Malays J Pathol. 2015; 37(2): 153-8[PubMed]
  • 4. Bouma G, Burns SO, Thrasher AJ. Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology. 2009; 214(9-10): 778-90[DOI][PubMed]
  • 5. Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, et al. Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood. 2008; 112(10): 4158-69[DOI][PubMed]
  • 6. Thrasher AJ. New insights into the biology of Wiskott-Aldrich syndrome (WAS). Hematology Am Soc Hematol Educ Program. 2009; : 132-8[DOI][PubMed]
  • 7. Ozsahin H, Cavazzana-Calvo M, Notarangelo LD, Schulz A, Thrasher AJ, Mazzolari E, et al. Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation. Blood. 2008; 111(1): 439-45[DOI][PubMed]
  • 8. Almagor Y, Revel-Vilk S, Averbuch D, Mechoulam H, Engelhard D, Resnick IB, et al. Congenital cytomegalovirus infection and Wiskott-Aldrich syndrome successfully treated with unrelated cord blood transplantation. Pediatr Blood Cancer. 2011; 57(4): 681-3[DOI][PubMed]
  • 9. Kobayashi R, Ariga T, Nonoyama S, Kanegane H, Tsuchiya S, Morio T, et al. Outcome in patients with Wiskott-Aldrich syndrome following stem cell transplantation: an analysis of 57 patients in Japan. Br J Haematol. 2006; 135(3): 362-6[DOI][PubMed]
  • 10. Massaad MJ, Ramesh N, Geha RS. Wiskott-Aldrich syndrome: a comprehensive review. Ann N Y Acad Sci. 2013; 1285: 26-43[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

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