Iranian Journal of Pediatrics

Published by: Kowsar

The Effect of Respiratory Syncytial Virus on the Severity of Acute Bronchiolitis in Hospitalized Infants: A Prospective Study from Turkey

Sule Gokce 1 , * , Zafer Kurugol 2 , Zeynep Cerit 3 and Candan Cicek 4
Authors Information
1 Department of Pediatrics, General Pediatrics Unit, Ege University Childrens’ Hospital, Izmir, Turkey
2 Division of Pediatric Infection, Department of Pediatrics, Ege University, Izmir, Turkey
3 Near East University, Department of Pediatrics, Nicosia, Cyprus
4 Department of Microiology, Ege University, Faculty of Medicine, Izmir, Turkey
Article information
  • Iranian Journal of Pediatrics: April 2018, 28 (2); e61034
  • Published Online: March 13, 2018
  • Article Type: Research Article
  • Received: August 29, 2017
  • Revised: December 19, 2017
  • Accepted: February 8, 2018
  • DOI: 10.5812/ijp.61034

To Cite: Gokce S, Kurugol Z, Cerit Z, Cicek C. The Effect of Respiratory Syncytial Virus on the Severity of Acute Bronchiolitis in Hospitalized Infants: A Prospective Study from Turkey, Iran J Pediatr. 2018 ; 28(2):e61034. doi: 10.5812/ijp.61034.

Copyright © 2018, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Wainwright C. Acute viral bronchiolitis in children- a very common condition with few therapeutic options. Paediatr Respir Rev. 2010;11(1):39-45. quiz 45. doi: 10.1016/j.prrv.2009.10.001. [PubMed: 20113991].
  • 2. WHO . WHO Consultation on respiratory syncytial virus (RSV) vaccine development. WHO; 2015.
  • 3. Zorc JJ, Hall CB. Bronchiolitis: recent evidence on diagnosis and management. Pediatrics. 2010;125(2):342-9. doi: 10.1542/peds.2009-2092. [PubMed: 20100768].
  • 4. Bamberger E, Srugo I, Abu Raya B, Segal E, Chaim B, Kassis I. What is the clinical relevance of respiratory syncytial virus bronchiolitis?: findings from a multi-center, prospective study. Eur J Clin Microbiol Infect Dis. 2012;31(12):3323-30. doi: 10.1007/s10096-012-1699-2. [PubMed: 22825246].
  • 5. Garcia CG, Bhore R, Soriano-Fallas A, Trost M, Chason R, Ramilo O. Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics. 2010;126(6):1453-60. doi: 10.1542/peds.2010-0507. [PubMed: 21098154].
  • 6. Mansbach JM, Piedra PA, Teach SJ, Sullivan AF, Forgey T, Clark S. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med. 2012;166(8):700-6. doi: 10.1001/archpediatrics.2011.1669. [PubMed: 22473882].
  • 7. Wolf DG, Greenberg D, Kalkstein D, Shemer-Avni Y, Givon-Lavi N, Saleh N. Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children. Pediatr Infect Dis J. 2006;25(4):320-4. doi: 10.1097/ [PubMed: 16567983].
  • 8. Wilkesmann A, Schildgen O, Eis-Hubinger AM, Geikowski T, Glatzel T, Lentze MJ. Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections. Eur J Pediatr. 2006;165(7):467-75. doi: 10.1007/s00431-006-0105-4. [PubMed: 16607540].
  • 9. Wang EE, Milner RA, Navas L, Maj H. Observer agreement for respiratory signs and oximetry in infants hospitalized with lower respiratory infections. Am Rev Respir Dis. 1992;145(1):106-9. doi: 10.1164/ajrccm/145.1.106. [PubMed: 1731571].
  • 10. Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134(5):1474-502. doi: 10.1542/peds.2014-2742. [PubMed: 25349312].
  • 11. Purcell K, Fergie J. Lack of usefulness of an abnormal white blood cell count for predicting a concurrent serious bacterial infection in infants and young children hospitalized with respiratory syncytial virus lower respiratory tract infection. Pediatr Infect Dis J. 2007;26(4):311-5. doi: 10.1097/01.inf.0000258627.23337.00. [PubMed: 17414393].
  • 12. Midulla F, Scagnolari C, Bonci E, Pierangeli A, Antonelli G, De Angelis D. Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants. Arch Dis Child. 2010;95(1):35-41. doi: 10.1136/adc.2008.153361. [PubMed: 19822538].
  • 13. Antunes H, Rodrigues H, Silva N, Ferreira C, Carvalho F, Ramalho H. Etiology of bronchiolitis in a hospitalized pediatric population: prospective multicenter study. J Clin Virol. 2010;48(2):134-6. doi: 10.1016/j.jcv.2010.03.002. [PubMed: 20362492].
  • 14. Stempel HE, Martin ET, Kuypers J, Englund JA, Zerr DM. Multiple viral respiratory pathogens in children with bronchiolitis. Acta Paediatr. 2009;98(1):123-6. doi: 10.1111/j.1651-2227.2008.01023.x. [PubMed: 18785966].
  • 15. Ong GM, Wyatt DE, O'Neill HJ, McCaughey C, Coyle PV. A comparison of nested polymerase chain reaction and immunofluorescence for the diagnosis of respiratory infections in children with bronchiolitis, and the implications for a cohorting strategy. J Hosp Infect. 2001;49(2):122-8. doi: 10.1053/jhin.2001.1044. [PubMed: 11567557].
  • 16. Hervas D, Reina J, Yanez A, del Valle JM, Figuerola J, Hervas JA. Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis. Eur J Clin Microbiol Infect Dis. 2012;31(8):1975-81. doi: 10.1007/s10096-011-1529-y. [PubMed: 22240853].
  • 17. Martinez-Roig A, Salvado M, Caballero-Rabasco MA, Sanchez-Buenavida A, Lopez-Segura N, Bonet-Alcaina M. Viral coinfection in childhood respiratory tract infections. Arch Bronconeumol. 2015;51(1):5-9. doi: 10.1016/j.arbres.2014.01.018. [PubMed: 24666712].
  • 18. Asner SA. Respiratory viruses in pediatrics: what's new?. 17. Rev Med Suisse; 2016. p. 358-61.
  • 19. Ramagopal G. Demographic,Clinical and Hematological Profile of Children with Bronchiolitis: A Comparative Study between Respiratory Synctial Virus [RSV] and [Non RSV] Groups. J Clinical Diagnostic Res. 2016. doi: 10.7860/jcdr/2016/20331.8262.
  • 20. Goka EA, Vallely PJ, Mutton KJ, Klapper PE. Single and multiple respiratory virus infections and severity of respiratory disease: a systematic review. Paediatr Respir Rev. 2014;15(4):363-70. doi: 10.1016/j.prrv.2013.11.001. [PubMed: 24361079].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments