Iranian Journal of Pediatrics

Published by: Kowsar

An Exhaustive Echocardiographic Analysis of Left Ventricular Structure and Functions in Children with Duchenne Muscular Dystrophy

Helen Bornaun 1 , * , Murat Muhtar Yilmazer 2 , Savas Dedeoglu 3 and Reyhan Dedeoglu 4
Authors Information
1 Department of Pediatric Cardiology, Kanuni Sultan Suleyman Educational and Research Hospital, Istanbul, Turkey
2 Department of Pediatric Cardiology, SBU Izmir Dr. Behcet Uz Children’s Hospital, Izmir, Turkey
3 Department of Health Sciences, Uskudar University, Istanbul, Turkey
4 Department of Pediatric Cardiology, Cerrahpasa Medical Faculty Istanbul University, Istanbul, Turkey
Article information
  • Iranian Journal of Pediatrics: August 2018, 28 (4); e62204
  • Published Online: May 30, 2018
  • Article Type: Research Article
  • Received: October 19, 2017
  • Revised: January 30, 2018
  • Accepted: April 2, 2018
  • DOI: 10.5812/ijp.62204

To Cite: Bornaun H, Muhtar Yilmazer M, Dedeoglu S, Dedeoglu R. An Exhaustive Echocardiographic Analysis of Left Ventricular Structure and Functions in Children with Duchenne Muscular Dystrophy, Iran J Pediatr. 2018 ;28(4):e62204. doi: 10.5812/ijp.62204.

Abstract
Copyright © 2018, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
References
  • 1. Eidem BW. Identifying abnormalities of left ventricular systolic function in asymptomatic "carriers" of dystrophin mutations: getting better...But not there yet. J Am Soc Echocardiogr. 2010;23(8):854-6. doi: 10.1016/j.echo.2010.06.025. [PubMed: 20659664].
  • 2. Gumerson JD, Michele DE. The dystrophin-glycoprotein complex in the prevention of muscle damage. J Biomed Biotechnol. 2011;2011:210797. doi: 10.1155/2011/210797. [PubMed: 22007139]. [PubMed Central: PMC3189583].
  • 3. Ameen V, Robson LG. Experimental models of duchenne muscular dystrophy: relationship with cardiovascular disease. Open Cardiovasc Med J. 2010;4:265-77. doi: 10.2174/1874192401004010265. [PubMed: 21258567]. [PubMed Central: PMC3024556].
  • 4. Zhou L, Lu H. Targeting fibrosis in Duchenne muscular dystrophy. J Neuropathol Exp Neurol. 2010;69(8):771-6. doi: 10.1097/NEN.0b013e3181e9a34b. [PubMed: 20613637]. [PubMed Central: PMC2916968].
  • 5. Shevchenko KG. Selected issues of the Duchenne Muscular Dystrophy gene and cell therapy. Cell Ther Transplant. 2012;3(1).
  • 6. Verhaert D, Richards K, Rafael-Fortney JA, Raman SV. Cardiac involvement in patients with muscular dystrophies: magnetic resonance imaging phenotype and genotypic considerations. Circ Cardiovasc Imaging. 2011;4(1):67-76. doi: 10.1161/CIRCIMAGING.110.960740. [PubMed: 21245364]. [PubMed Central: PMC3057042].
  • 7. Gulati S, Saxena A, Kumar V, Kalra V. Duchenne muscular dystrophy: prevalence and patterns of cardiac involvement. Indian J Pediatr. 2005;72(5):389-93. [PubMed: 15973020].
  • 8. Yilmazer MM, Omeroglu RE, Bornaun H, Oner N, Nisli K, Ertugrul T. Repolarization abnormalities in Duchenne-type muscular dystrophy. Turk Kardiyol Dern Ars. 2009;37(8):538-42. [PubMed: 20200454].
  • 9. Percival JM, Adamo CM, Beavo JA, Froehner SC. Evaluation of the therapeutic utility of phosphodiesterase 5A inhibition in the mdx mouse model of duchenne muscular dystrophy. Handb Exp Pharmacol. 2011;(204):323-44. doi: 10.1007/978-3-642-17969-3_14. [PubMed: 21695647]. [PubMed Central: PMC4063120].
  • 10. Burke W. Genomics as a probe for disease biology. N Engl J Med. 2003;349(10):969-74. doi: 10.1056/NEJMra012479. [PubMed: 12954746].
  • 11. Jefferies JL, Eidem BW, Belmont JW, Craigen WJ, Ware SM, Fernbach SD, et al. Genetic predictors and remodeling of dilated cardiomyopathy in muscular dystrophy. Circulation. 2005;112(18):2799-804. doi: 10.1161/CIRCULATIONAHA.104.528281. [PubMed: 16246949].
  • 12. Chetboul V, Escriou C, Tessier D, Richard V, Pouchelon JL, Thibault H, et al. Tissue Doppler imaging detects early asymptomatic myocardial abnormalities in a dog model of Duchenne's cardiomyopathy. Eur Heart J. 2004;25(21):1934-9. doi: 10.1016/j.ehj.2004.09.007. [PubMed: 15522473].
  • 13. Chetboul V, Carlos C, Blot S, Thibaud JL, Escriou C, Tissier R, et al. Tissue Doppler assessment of diastolic and systolic alterations of radial and longitudinal left ventricular motions in Golden Retrievers during the preclinical phase of cardiomyopathy associated with muscular dystrophy. Am J Vet Res. 2004;65(10):1335-41. [PubMed: 15524319].
  • 14. Pradhan S. Valley sign in duchenne muscular dystrophy: importance in patients with inconspicuous calves. Neurol India. 2002;50(2):184-6. [PubMed: 12134184].
  • 15. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification. Eur J Echocardiogr. 2006;7(2):79-108. doi: 10.1016/j.euje.2005.12.014. [PubMed: 16458610].
  • 16. Gottdiener JS, Bednarz J, Devereux RB, Gardin J, Klein AL, Manning WJ, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials: A report from the american society of echocardiography's guidelines and standards committee and the task force on echocardiography in clinical trials. J Am Soc Echocardiograph. 2004;17(10):1086-119.
  • 17. Teichholz LE, Kreulen T, Herman MV, Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol. 1976;37(1):7-11. [PubMed: 1244736].
  • 18. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440-63. doi: 10.1016/j.echo.2005.10.005. [PubMed: 16376782].
  • 19. Verma A, Meris A, Skali H, Ghali JK, Arnold JM, Bourgoun M, et al. Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan In Acute myocardial iNfarcTion) Echocardiographic Study. JACC Cardiovasc Imaging. 2008;1(5):582-91. doi: 10.1016/j.jcmg.2008.05.012. [PubMed: 19356485].
  • 20. Maurer MS, Spevack D, Burkhoff D, Kronzon I. Diastolic dysfunction: can it be diagnosed by Doppler echocardiography? J Am Coll Cardiol. 2004;44(8):1543-9. doi: 10.1016/j.jacc.2004.07.034. [PubMed: 15489083].
  • 21. Nagueh SF, Smiseth OA, Appleton CP, Byrd B3, Dokainish H, Edvardsen T, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277-314. doi: 10.1016/j.echo.2016.01.011. [PubMed: 27037982].
  • 22. Sohn DW, Chai IH, Lee DJ, Kim HC, Kim HS, Oh BH, et al. Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol. 1997;30(2):474-80. [PubMed: 9247521].
  • 23. Osterne EC, Haddad J, da Motta VP, da Motta PA, Osterne TE, Osterne NM, et al. Determination of mitral valve area through pressure half-time measurements in the left atrium and pulmonary capillary wedge. Arq Bras Cardiol. 2006;87(6):705-10. [PubMed: 17262107].
  • 24. Rafael JA, Cox GA, Corrado K, Jung D, Campbell KP, Chamberlain JS. Forced expression of dystrophin deletion constructs reveals structure-function correlations. J Cell Biol. 1996;134(1):93-102. [PubMed: 8698825]. [PubMed Central: PMC2120912].
  • 25. Corrado K, Rafael JA, Mills PL, Cole NM, Faulkner JA, Wang K, et al. Transgenic mdx mice expressing dystrophin with a deletion in the actin-binding domain display a "mild Becker" phenotype. J Cell Biol. 1996;134(4):873-84. [PubMed: 8769413]. [PubMed Central: PMC2120962].
  • 26. Ashwath ML, Jacobs IB, Crowe CA, Ashwath RC, Super DM, Bahler RC. Left ventricular dysfunction in duchenne muscular dystrophy and genotype. Am J Cardiol. 2014;114(2):284-9. doi: 10.1016/j.amjcard.2014.04.038. [PubMed: 24878125]. [PubMed Central: PMC4768789].
  • 27. Angelini C, Di Leo R, Cudia P. Autonomic regulation in muscular dystrophy. Front Physiol. 2013;4:257. doi: 10.3389/fphys.2013.00257. [PubMed: 24065927]. [PubMed Central: PMC3778236].
  • 28. Yilmazer MM, Omeroglu RE, Bornaun H, Oner N, Nisli K. Duchenne Muskuler Distrofi'de Kardiyak Otonomik Disfonksiyonun Degerlendirilmesi. J Neurol Sci. 2010;27(1):12-9. Turkish.
  • 29. Burchfield JS, Xie M, Hill JA. Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation. 2013;128(4):388-400. doi: 10.1161/CIRCULATIONAHA.113.001878. [PubMed: 23877061]. [PubMed Central: PMC3801217].
  • 30. Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, et al. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2012;28(1):99-107. doi: 10.1007/s10554-010-9781-2. [PubMed: 21222036].
  • 31. Markham LW, Michelfelder EC, Border WL, Khoury PR, Spicer RL, Wong BL, et al. Abnormalities of diastolic function precede dilated cardiomyopathy associated with Duchenne muscular dystrophy. J Am Soc Echocardiogr. 2006;19(7):865-71. doi: 10.1016/j.echo.2006.02.003. [PubMed: 16824995].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments