Iranian Journal of Pediatrics

Published by: Kowsar

The Evaluation of Optimum Radiation Dose to Prevent Transfusion-Associated Graft-Versus-Host Disease Among the Iranian Population

Bahareh Aboufazeli 1 , Ahmad Tamaddoni 2 , * , Ali Shabestani Monfared 3 , Ebrahim Zabihi 1 , Zeinab Abedian 1 , Seied Rabi Mahdavi 4 , Masoome Karimi 5 and Sajad Borzoueisileh 1
Authors Information
1 Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, IR Iran
2 Amirkola Hospital, Babol University of Medical Sciences, Babol, IR Iran
3 Cancer Research Center, Babol University of Medical Sciences, Babol, IR Iran
4 Medical Physics Department, Iran University of Medical Sciences, Tehran, IR Iran
5 Shahid Rajaei Hospital, Babol University of Medical Sciences, Babol, IR Iran
Article information
  • Iranian Journal of Pediatrics: August 2018, 28 (4); e62300
  • Published Online: July 2, 2018
  • Article Type: Research Article
  • Received: September 28, 2017
  • Revised: December 9, 2017
  • Accepted: December 16, 2017
  • DOI: 10.5812/ijp.62300

To Cite: Aboufazeli B, Tamaddoni A, Shabestani Monfared A, Zabihi E, Abedian Z, et al. The Evaluation of Optimum Radiation Dose to Prevent Transfusion-Associated Graft-Versus-Host Disease Among the Iranian Population, Iran J Pediatr. 2018 ; 28(4):e62300. doi: 10.5812/ijp.62300.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Adams F, Bellairs G, Bird A, Oguntibeju O. Biochemical storage lesions occurring in nonirradiated and irradiated red blood cells: a brief review. BioMed Res Int. 2015;2015.
  • 2. Kopolovic I, Ostro J, Tsubota H, Lin Y, Cserti-Gazdewich CM, Messner HA, et al. A systematic review of transfusion-associated graft-versus-host disease. Blood. 2015;126(3):406-14. doi: 10.1182/blood-2015-01-620872. [PubMed: 25931584].
  • 3. Hathaway WE, Fulginiti VA, Pierce CW, Githens JH, Pearlman DS, Muschenheim F, et al. Graft-vs-host reaction following a single blood transfusion. JAMA. 1967;201(13):1015-20. [PubMed: 6072477].
  • 4. Parkman R, Mosier D, Umansky I, Cochran W, Carpenter CB, Rosen FS. Graft-versus-host disease after intrauterine and exchange transfusions for hemolytic disease of the newborn. N Engl J Med. 1974;290(7):359-63. doi: 10.1056/NEJM197402142900703. [PubMed: 4149239].
  • 5. Shastry S, Ramya B, Ninan J, Srinidhi GC, Bhat SS, Fernandes DJ. Linear accelerator: a reproducible, efficacious and cost effective alternative for blood irradiation. Transfus Apher Sci. 2013;49(3):528-32. doi: 10.1016/j.transci.2013.03.007. [PubMed: 23541712].
  • 6. Moroff G, Leitman SF, Luban NL. Principles of blood irradiation, dose validation, and quality control. Transfusion. 1997;37(10):1084-92. [PubMed: 9354830].
  • 7. Janatpour K, Denning L, Nelson K, Betlach B, Mackenzie M, Holland P. Comparison of X-ray vs. gamma irradiation of CPDA-1 red cells. Vox Sang. 2005;89(4):215-9. doi: 10.1111/j.1423-0410.2005.00699.x. [PubMed: 16262754].
  • 8. Green L, Allard S, Cardigan R. Modern banking, collection, compatibility testing and storage of blood and blood components. Anaesthesia. 2015;70 Suppl 1:3-9. e2. doi: 10.1111/anae.12912. [PubMed: 25440389].
  • 9. Shabestani Monfared A, Mozdarani H, Samavat H, Hashemoghli A. Chromosomal aberrations in radiation workers of radiology departments in Northern Iran-Babol. Int J Low Radiat. 2006;3(1):83-7.
  • 10. Shabestani Monfared A, Borzoueisileh S, Zabihi E, Amiri M, Abedian S. Predicting factors of radiosensitivity in individual radiotherapy. J Babol Univ Med Sci. 2015;17(10):67-73.
  • 11. Elahimanesh F, Shabestani Monfared A, Khosravifarsani M, Akhavan Niaki H, Abedian Z, Hajian-Tilaki K, et al. Is Radiosensitivity Associated to Different Types of Blood Groups? (A cytogenetic study). Int J Mol Cell Med. 2013;2(3):131-5. [PubMed: 24551803]. [PubMed Central: PMC3920532].
  • 12. Khosravifarsani M, Monfared AS, Elahimanesh F, Borzoueisileh S, Hajian-Tilaki K, Seyfizadeh N, et al. Is there association between handedness and radiosensitivity in breast cancer women? Med Oncol. 2012;29(4):2552-5. doi: 10.1007/s12032-011-0153-0. [PubMed: 22219084].
  • 13. Borzoueisileh S, Monfared AS, Abediankenari S, Mostafazadeh A. The assessment of cytotoxic T cell and natural killer cells activity in residents of high and ordinary background radiation areas of Ramsar-Iran. J Med Phys. 2013;38(1):30-3. doi: 10.4103/0971-6203.106602. [PubMed: 23531635]. [PubMed Central: PMC3607342].
  • 14. Solomon SR, Tran T, Carter CS, Donnelly S, Hensel N, Schindler J, et al. Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation. Cytotherapy. 2002;4(5):395-406. doi: 10.1080/146532402320775982. [PubMed: 12473206].
  • 15. Valerius N, Johansen KS, Nielsen OS, Platz P, Rosenkvist J, Sorensen H. Effect of in Vitro X‐Irradiation on Lymphocyte and Granulocyte Function. Europ J Haematol. 1981;27(1):9-18.
  • 16. Lowenthal RM, Challis DR, Griffiths AE, Chappell RA, Goulder PJ. Transfusion-associated graft-versus-host disease: report of an occurrence following the administration of irradiated blood. Transfusion. 1993;33(6):524-9. [PubMed: 8516797].
  • 17. Rosen NR, Weidner JG, Boldt HD, Rosen DS. Prevention of transfusion-associated graft-versus-host disease: selection of an adequate dose of gamma radiation. Transfusion. 1993;33(2):125-7. [PubMed: 8430450].
  • 18. Asai T, Inaba S, Ohto H, Osada K, Suzuki G, Takahashi K, et al. Guidelines for irradiation of blood and blood components to prevent post-transfusion graft-vs.-host disease in Japan. Transfus Med. 2000;10(4):315-20. [PubMed: 11123816].
  • 19. Nadi S, Monfared AS, Mozdarani H, Mahmodzade A, Pouramir M. Effects of Arbutin on Radiation-Induced Micronuclei in Mice Bone Marrow Cells and Its Definite Dose Reduction Factor. Iran J Med Sci. 2016;41(3):180-5. [PubMed: 27217601]. [PubMed Central: PMC4876295].
  • 20. Davey RJ. Transfusion-associated graft-versus-host disease and the irradiation of blood components. Immunol Invest. 1995;24(1-2):431-4. [PubMed: 7713602].
  • 21. Goes EG, Borges JC, Covas DT, Orellana MD, Palma PV, Morais FR, et al. Quality control of blood irradiation: determination T cells radiosensitivity to cobalt-60 gamma rays. Transfusion. 2006;46(1):34-40. doi: 10.1111/j.1537-2995.2005.00669.x. [PubMed: 16398728].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments