Iranian Journal of Pediatrics

Published by: Kowsar

Serum Heat Shock Protein Levels in IgA Nephropathy

Zeynep Yuruk Yildirim 1 , Bagdagul Aksu 1 , Asuman Gedikbasi 2 , Aysel Kiyak 3 , Gul Ozcelik 4 , Alev Yilmaz 1 , * , Cemile Pehlivanoglu 1 , Nurver Akinci 4 , Yasemin Ozluk 5 , Aysim Ozagari 6 , Isin Kilicaslan 5 and Sevinc Emre 1
Authors Information
1 Pediatric Nephrology Department, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
2 Biochemistry Department, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
3 Pediatric Nephrology Department, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
4 Pediatric Nephrology Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
5 Pathology Department, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
6 Pathology Department, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
Article information
  • Iranian Journal of Pediatrics: June 2018, 28 (3); e63358
  • Published Online: May 30, 2018
  • Article Type: Research Article
  • Received: October 28, 2017
  • Revised: December 25, 2017
  • Accepted: January 21, 2018
  • DOI: 10.5812/ijp.63358

To Cite: Yildirim Z Y, Aksu B, Gedikbasi A, Kiyak A, Ozcelik G, et al. Serum Heat Shock Protein Levels in IgA Nephropathy, Iran J Pediatr. 2018 ; 28(3):e63358. doi: 10.5812/ijp.63358.

Copyright © 2018, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Beck FX, Neuhofer W, Muller E. Molecular chaperones in the kidney: distribution, putative roles, and regulation. Am J Physiol Renal Physiol. 2000;279(2):F203-15. doi: 10.1152/ajprenal.2000.279.2.F203. [PubMed: 10919839].
  • 2. Sreedharan R, Van Why SK. Heat shock proteins in the kidney. Pediatr Nephrol. 2016;31(10):1561-70. doi: 10.1007/s00467-015-3297-x.
  • 3. Razzaque MS, Kumatori A, Harada T, Taguchi T. Coexpression of collagens and collagen-binding heat shock protein 47 in human diabetic nephropathy and IgA nephropathy. Nephron. 1998;80(4):434-43. doi: 10.1159/000045217. [PubMed: 9832643].
  • 4. Chebotareva NV, Neprintseva NV, Bobkova IN, Kozlovskaia LV. [Investigation of 70-kDa heat shock protein in the serum and urine of patients with chronic glomerulonephritis]. Ter Arkh. 2014;86(6):18-23. [PubMed: 25095651].
  • 5. Lang A, Benke D, Eitner F, Engel D, Ehrlich S, Breloer M, et al. Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal. J Am Soc Nephrol. 2005;16(2):383-91. doi: 10.1681/ASN.2004040276. [PubMed: 15601747].
  • 6. Lebherz-Eichinger D, Krenn CG, Roth GA. Keratin 18 and heat-shock protein in chronic kidney disease. Adv Clin Chem. 2013;62:123-49. [PubMed: 24772666].
  • 7. Nakanishi K, Yoshikawa N. Immunoglobulin A Nephropathies in Children (Includes HSP). In: Avner ED, Harmon WE, Niaudet P, Yoshikawa N, Emma F, Goldstein SL, editors. Pediatric Nephrology. 7th ed. Berlin Heidelberg: Springer-Verlag; 2016. p. 983-1033. doi: 10.1007/978-3-662-43596-0_28.
  • 8. Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Hashimura Y, et al. Validity of the Oxford classification of IgA nephropathy in children. Pediatr Nephrol. 2012;27(5):783-92. doi: 10.1007/s00467-011-2061-0. [PubMed: 22134880].
  • 9. Coppo R, Davin JC. The difficulty in considering modifiable pathology risk factors in children with IgA nephropathy: crescents and timing of renal biopsy. Pediatr Nephrol. 2015;30(2):189-92. doi: 10.1007/s00467-014-2954-9. [PubMed: 25318618].
  • 10. Ozen S, Duzova A. Henoch-Schonlein Purpura, Polyarteritis Nodosa, Wegener's Granulomatosis, and Other Vasculitides. In: Cimaz R LT, editor. Pediatrics in Systemic Autoimmune Diseases. 1st ed. Amsterdam: Elsevier; 2014. p. 151-67.
  • 11. Kang Y, Park JS, Ha YJ, Kang MI, Park HJ, Lee SW, et al. Differences in clinical manifestations and outcomes between adult and child patients with Henoch-Schonlein purpura. J Korean Med Sci. 2014;29(2):198-203. doi: 10.3346/jkms.2014.29.2.198. [PubMed: 24550645]. [PubMed Central: PMC3923997].
  • 12. Dillon MJ, Ozen S. A new international classification of childhood vasculitis. Pediatr Nephrol. 2006;21(9):1219-22. doi: 10.1007/s00467-006-0181-8. [PubMed: 16821024].
  • 13. Working Group of the International Ig AN, the Renal Pathology S, Roberts IS, Cook HT, Troyanov S, Alpers CE, et al. The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int. 2009;76(5):546-56. doi: 10.1038/ki.2009.168. [PubMed: 19571790].
  • 14. Roberts IS. Pathology of IgA nephropathy. Nat Rev Nephrol. 2014;10(8):445-54. doi: 10.1038/nrneph.2014.92. [PubMed: 24861083].
  • 15. A report of the International Study of Kidney Disease in Children. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. J Pediatr. 1981;98(4):561-4. [PubMed: 7205481].
  • 16. National High Blood Pressure Education Program Working Group on High Blood Pressure in C.Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114(2 Suppl 4th Report):555-76. [PubMed: 15286277].
  • 17. Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20(3):629-37. doi: 10.1681/ASN.2008030287. [PubMed: 19158356]. [PubMed Central: PMC2653687].
  • 18. Yap HK, Lau PY. Hematuria and Proteinuria. In: Geary FD SF, editor. Comprehensive Pediatric Nephrology. 1st ed. Philadelphia: Mosby Elsevier; 2009. p. 179-93.
  • 19. Xu L, Yang HC, Hao CM, Lin ST, Gu Y, Ma J. Podocyte number predicts progression of proteinuria in IgA nephropathy. Mod Pathol. 2010;23(9):1241-50. doi: 10.1038/modpathol.2010.110. [PubMed: 20495534].
  • 20. Smoyer WE, Gupta A, Mundel P, Ballew JD, Welsh MJ. Altered expression of glomerular heat shock protein 27 in experimental nephrotic syndrome. J Clin Invest. 1996;97(12):2697-704. doi: 10.1172/JCI118723. [PubMed: 8675679]. [PubMed Central: PMC507361].
  • 21. Smoyer WE, Ransom RF. Hsp27 regulates podocyte cytoskeletal changes in an in vitro model of podocyte process retraction. FASEB J. 2002;16(3):315-26. doi: 10.1096/fj.01-0681com. [PubMed: 11874981].

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