Iranian Journal of Pediatrics

Published by: Kowsar

A Rare Overgrowth Disorder: Sotos Syndrome

Burcin Sanlidag 1 , * , Ceyhun Dalkan 1 , Nilufer Gali 1 , Ozlem Sahaloglu 1 , Nerin Bahceciler Onder 1 and Eray Dirik 1
Authors Information
1 Department of Pediatrics, Near East University, Nicosia, Cyprus
Article information
  • Iranian Journal of Pediatrics: April 2017, 27 (2); e6504
  • Published Online: October 8, 2016
  • Article Type: Letter
  • Received: April 22, 2016
  • Revised: August 10, 2016
  • Accepted: September 12, 2016
  • DOI: 10.5812/ijp.6504

To Cite: Sanlidag B, Dalkan C, Gali N, Sahaloglu O, Onder N B, et al. A Rare Overgrowth Disorder: Sotos Syndrome, Iran J Pediatr. 2017 ; 27(2):e6504. doi: 10.5812/ijp.6504.

Copyright © 2016, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. Sotos JF, Dodge PR, Muirhead D, Crawford JD, Talbot NB. Cerebral Gigantism in Childhood. A Syndrome of Excessively Rapid Growth and Acromegalic Features and a Nonprogressive Neurologic Disorder. N Engl J Med. 1964; 271: 109-16[DOI][PubMed]
  • 2. Rath A, Wakap SN, Demarest S, Lanneau V. Prevalence of rare diseases: Bibliographic data. Orphanet Report Series. 2012; 1: 26
  • 3. Cole TR, Hughes HE. Sotos syndrome: a study of the diagnostic criteria and natural history. J Med Genet. 1994; 31(1): 20-32[PubMed]
  • 4. Kurotaki N, Imaizumi K, Harada N, Masuno M, Kondoh T, Nagai T, et al. Haploinsufficiency of NSD1 causes Sotos syndrome. Nat Genet. 2002; 30(4): 365-6[DOI][PubMed]
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  • 6. Tatton-Brown K, Douglas J, Coleman K, Baujat G, Cole TR, Das S, et al. Genotype-phenotype associations in Sotos syndrome: an analysis of 266 individuals with NSD1 aberrations. Am J Hum Genet. 2005; 77(2): 193-204[DOI][PubMed]
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  • 8. de Boer L, Kant SG, Karperien M, van Beers L, Tjon J, Vink GR, et al. Genotype-phenotype correlation in patients suspected of having Sotos syndrome. Horm Res. 2004; 62(4): 197-207[DOI][PubMed]
  • 9. Kossard S. Defining lymphocytic vasculitis. Australas J Dermatol. 2000; 41(3): 149-55[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

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