Iranian Journal of Pediatrics

Published by: Kowsar

Is Malondialdehyde an Acceptable Biomarker of Oxidative Stress In Children with Down Syndrome?

Abolghasem Jouyban 1 and Maryam Khoubnasabjafari 2 , *
Authors Information
1 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Iranian Journal of Pediatrics: October 2017, 27 (5); e6892
  • Published Online: October 23, 2017
  • Article Type: Letter
  • Received: May 8, 2016
  • Accepted: June 18, 2017
  • DOI: 10.5812/ijp.6892

To Cite: Jouyban A, Khoubnasabjafari M. Is Malondialdehyde an Acceptable Biomarker of Oxidative Stress In Children with Down Syndrome?, Iran J Pediatr. 2017 ; 27(5):e6892. doi: 10.5812/ijp.6892.

Copyright © 2017, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. He J, Li T, Chen J, Liu Y, Xiong F, Yang J, et al. Plasma antioxidant enzymes and lipoperoxidation status in children with Down syndrome. Clin Biochem. 2016; 49(1-2): 61-5[DOI][PubMed]
  • 2. Muchova J, Sustrova M, Garaiova I, Liptakova A, Blazicek P, Kvasnicka P, et al. Influence of age on activities of antioxidant enzymes and lipid peroxidation products in erythrocytes and neutrophils of Down syndrome patients. Free Radic Biol Med. 2001; 31(4): 499-508[PubMed]
  • 3. Capone G, Kim P, Jovanovich S, Payne L, Freund L, Welch K, et al. Evidence for increased mitochondrial superoxide production in Down syndrome. Life Sci. 2002; 70(24): 2885-95[PubMed]
  • 4. Gromadzinska J, Wasowicz W, Sklodowska M, Strozynski H. Glutathione peroxidase activity, lipid peroxides and selenium status in blood in patients with Down's syndrome. J Clin Chem Clin Biochem. 1988; 26(5): 255-8[PubMed]
  • 5. Mehar Sulthana S, Nandha Kumar S, Sridhar MG, Vishnu Bhat B, Ramachandra Rao K. Oxidative stress in children with Down syndrome. Curr Pediatr. Res. 2012; 16(2): 111-4
  • 6. Casado A, Lopez-Fernandez ME, Ruiz R. Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21. Clin Chem Lab Med. 2007; 45(1): 59-62[DOI][PubMed]
  • 7. Garaiova I, Muchova J, Sustrova M, Blazicek P, Sivonova M, Kvasnicka P, et al. The relationship between antioxidant systems and some markers of oxidative stress in persons with Down syndrome. Biologia. 2004; 59(6): 787-94
  • 8. Khoubnasabjafari M, Ansarin K, Jouyban A. Critical review of malondialdehyde analysis in biological samples. Curr Pharm Analysis. 2016; 12(1): 4-17
  • 9. Gil P, Farinas F, Casado A, Lopez-Fernandez E. Malondialdehyde: a possible marker of ageing. Gerontology. 2002; 48(4): 209-14[PubMed]
  • 10. Inal ME, Kanbak G, Sunal E. Antioxidant enzyme activities and malondialdehyde levels related to aging. Clin Chim Acta. 2001; 305(1-2): 75-80[PubMed]
  • 11. Inal ME, Sunal E, Kanbak G, Zeytinoglu S. Effects of postmenopausal hormone replacement and alpha-tocopherol on the lipid profiles and antioxidant status. Clin Chim Acta. 1997; 268(1-2): 21-9[PubMed]
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