What Has National Screening Program Changed in Cases with Congenital Hypothyroidism?

AUTHORS

Şebnem Özgelen Özgelen 1 , Veysel Nijat Baş 2 , * , Semra Çetinkaya 3 , Zehra Aycan 4

How to Cite: Özgelen Ş Ö, Nijat Baş V , Çetinkaya S , Aycan Z . What Has National Screening Program Changed in Cases with Congenital Hypothyroidism?, Iran J Pediatr. 2014 ; 24(3):255-260.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 24 (3); 255-260
Published Online: May 08, 2014
Article Type: Research Article
Received: July 26, 2013
Accepted: March 04, 2014

Crossmark

CHEKING

READ FULL TEXT
Abstract

Objective: Since congenital hypothyroidism (CH) is the most important cause of preventable mental retardation, its screening is important. In this present study, it was aimed to evaluate congenital hypothyroidism cases before and after the initiation of screening program in year 2007 in our country.Methods: A total of 400 patients diagnosed with CH at our outpatient clinic were retrospectively evaluated. Age of diagnosis, complaint, clinical signs, and etiological distribution were detected and changes in those parameters were evaluated before and after year 2007, which was the initiation date of our national screening program.Findings: After year 2007, 70.6% of patients were diagnosed in the first month; 21.2% in 1-3 months; 6.5% in 3-6 months, and no patient was diagnosed after 9 months. Before initiation of the screening program, 48.4% of cases were diagnosed in the first month, the percentage was increased to 62.8% after the program; the increase was significant. While mental retardation was detected in 13.3% of patients before the screening, it was decreased to 4% after initiation of the program. An interesting finding was that age of treatment onset in girls was significantly higher than in boys before the screening; there was no difference between them after initiation of the screening.Conclusion: In this present study, it was observed that ages of diagnosis and treatment as well as mental retardation rates were significantly decreased in girls after the screening program, but ideal results have not been reached yet, and is expected to be reached in the future.

 

Keywords

Congenital Hypothyroidism Neonatal Screening Infant Thyroid Hormones

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

References

  • 1.

    References are available on the PDF.

  • COMMENTS

    LEAVE A COMMENT HERE: