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The Effect of Malnutrition on Protein Glycosylation in Children

AUTHORS

Oznur Bilen 1 , Zekiye Altun 2 , Nur Arslan 3 , * , Banu Onvural 4 , Pinar Akan 5 , Canan Coker 6

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How to Cite: Bilen O , Altun Z , Arslan N , Onvural B , Akan P , et al. The Effect of Malnutrition on Protein Glycosylation in Children, Iran J Pediatr. 2014 ; 24(3):273-279.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 24 (3); 273-279
Published Online: April 07, 2014
Article Type: Research Article
Received: April 15, 2013
Accepted: February 08, 2014

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Abstract

Objective: The goal of this study was to evaluate the effect of protein energy malnutrition on protein glycosylation by investigating transferrin isoform pattern and its relationship to the degree of malnutrition and the biochemical markers of nutritional status in children. Methods: Forty one children with mild (n=23) and severely/moderately (n=18) acute malnutrition and 29 controls were enrolled in the study. Serum transferrin isoforms were determined by isoelectric focusing electrophoresis. Transferrin, prealbumin, zinc, iron and insulin-like growth factor-1 (IGF-1) were measured using automated analyzers.Findings: Asialotransferrin and disialotransferrin were significantly higher in severely/moderately malnourished patients compared to controls (P=0.04 and P=0.04, respectively). Other transferrin isoform patterns were not different among three groups. Serum IGF-1, transferrin and iron levels of severely/ moderately malnourished group were significantly lower than tose of controls (P=0.001, 0.02 and 0.03, respectively). Serum prealbumin and zinc levels were similar in all three groups. Serum IGF-1, transferrin and iron levels, and all transferrin isoform patterns were not significantly different in mildly malnutrition group from other two groups.Conclusion: The changes in transferrin isoform pattern observed in malnourished patients may indicate that malnutrition is a catabolic state which has effects on glycosylation.

 

Keywords

Glycosylation Isoelectric Focusing Protein Energy Malnutrition Transferrin Isoform

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