Iranian Journal of Pediatrics

Published by: Kowsar

The Association of Serum Osteopontin Levels with Insulin Resistance in Obese, Dyslipidemic Children

Sahin Hamilcıkan 1 , Meltem Erol 1 , Ozlem Bostan Gayret 1 , Ovgu Buke 1 and Emrah Can 1 , *
Authors Information
1 Department of Pediatrics, Bagcilar Training and Research Hospital, Istanbul, Turkey
Article information
  • Iranian Journal of Pediatrics: February 2017, 27 (1); e7483
  • Published Online: December 25, 2016
  • Article Type: Research Article
  • Received: June 9, 2016
  • Revised: November 30, 2016
  • Accepted: December 20, 2016
  • DOI: 10.5812/ijp.7483

To Cite: Hamilcıkan S, Erol M, Bostan Gayret O, Buke O, Can E. The Association of Serum Osteopontin Levels with Insulin Resistance in Obese, Dyslipidemic Children, Iran J Pediatr. 2017 ; 27(1):e7483. doi: 10.5812/ijp.7483.

Copyright © 2016, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Kahles F, Findeisen HM, Bruemmer D. Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes. Mol Metab. 2014; 3(4): 384-93[DOI][PubMed]
  • 2. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003; 112(12): 1796-808[DOI][PubMed]
  • 3. Curat CA, Miranville A, Sengenes C, Diehl M, Tonus C, Busse R, et al. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes. 2004; 53(5): 1285-92[PubMed]
  • 4. Kiefer FW, Zeyda M, Todoric J, Huber J, Geyeregger R, Weichhart T, et al. Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations. Endocrinology. 2008; 149(3): 1350-7[DOI][PubMed]
  • 5. Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, et al. Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest. 2007; 117(10): 2877-88[DOI][PubMed]
  • 6. Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, et al. Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes. 2010; 59(4): 935-46[DOI][PubMed]
  • 7. Denhardt DT, Mistretta D, Chambers AF, Krishna S, Porter JF, Raghuram S, et al. Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter. Clin Exp Metastasis. 2003; 20(1): 77-84[PubMed]
  • 8. Sainger R, Grau JB, Poggio P, Branchetti E, Bavaria JE, Gorman JH 3rd, et al. Dephosphorylation of circulating human osteopontin correlates with severe valvular calcification in patients with calcific aortic valve disease. Biomarkers. 2012; 17(2): 111-8[DOI][PubMed]
  • 9. Reinehr T, de Sousa G, Toschke AM, Andler W. Comparison of metabolic syndrome prevalence using eight different definitions: a critical approach. Arch Dis Child. 2007; 92(12): 1067-72[DOI][PubMed]
  • 10. Braga-Tavares H, Fonseca H. Prevalence of metabolic syndrome in a Portuguese obese adolescent population according to three different definitions. Eur J Pediatr. 2010; 169(8): 935-40[DOI][PubMed]
  • 11. Lezhenko G, Gladun E. [The role of osteopontin and adiponectin in the development of insulin resistance and hypertension in obesed adolescents]. Georgian Med News. 2013; (214): 43-8[PubMed]
  • 12. Daniels SR, Greer FR, Committee on N. Lipid screening and cardiovascular health in childhood. Pediatrics. 2008; 122(1): 198-208[DOI][PubMed]
  • 13. Valerio G, Licenziati MR, Iannuzzi A, Franzese A, Siani P, Riccardi G, et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc Dis. 2006; 16(4): 279-84[DOI][PubMed]
  • 14. Strauss RS, Pollack HA. Epidemic increase in childhood overweight, 1986-1998. JAMA. 2001; 286(22): 2845-8[PubMed]
  • 15. Dietz WH, Robinson TN. Clinical practice. Overweight children and adolescents. N Engl J Med. 2005; 352(20): 2100-9[DOI][PubMed]
  • 16. van Dam RM, Willett WC, Manson JE, Hu FB. The relationship between overweight in adolescence and premature death in women. Ann Intern Med. 2006; 145(2): 91-7[PubMed]
  • 17. Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med. 1992; 327(19): 1350-5[DOI][PubMed]
  • 18. Must A, Phillips SM, Naumova EN. Occurrence and timing of childhood overweight and mortality: findings from the Third Harvard Growth Study. J Pediatr. 2012; 160(5): 743-50[DOI][PubMed]
  • 19. Bjorge T, Engeland A, Tverdal A, Smith GD. Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents. Am J Epidemiol. 2008; 168(1): 30-7[DOI][PubMed]
  • 20. Inge TH, King WC, Jenkins TM, Courcoulas AP, Mitsnefes M, Flum DR, et al. The effect of obesity in adolescence on adult health status. Pediatrics. 2013; 132(6): 1098-104[DOI][PubMed]
  • 21. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004; 350(23): 2362-74[DOI][PubMed]
  • 22. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med. 2003; 157(8): 821-7[DOI][PubMed]
  • 23. Lambert M, Paradis G, O'Loughlin J, Delvin EE, Hanley JA, Levy E. Insulin resistance syndrome in a representative sample of children and adolescents from Quebec, Canada. Int J Obes Relat Metab Disord. 2004; 28(7): 833-41[DOI][PubMed]
  • 24. Harel Z, Riggs S, Vaz R, Flanagan P, Harel D. Isolated low HDL cholesterol emerges as the most common lipid abnormality among obese adolescents. Clin Pediatr (Phila). 2010; 49(1): 29-34[DOI][PubMed]
  • 25. Williams DP, Going SB, Lohman TG, Harsha DW, Srinivasan SR, Webber LS, et al. Body fatness and risk for elevated blood pressure, total cholesterol, and serum lipoprotein ratios in children and adolescents. Am J Public Health. 1992; 82(3): 358-63[PubMed]
  • 26. Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic Risks and Severity of Obesity in Children and Young Adults. N Engl J Med. 2015; 373(14): 1307-17[DOI][PubMed]
  • 27. Healthy Study Group , Kaufman FR, Hirst K, Linder B, Baranowski T, Cooper DM, et al. Risk factors for type 2 diabetes in a sixth- grade multiracial cohort: the HEALTHY study. Diabetes Care. 2009; 32(5): 953-5[DOI][PubMed]
  • 28. Marcus MD, Baranowski T, DeBar LL, Edelstein S, Kaufman FR, Schneider M, et al. Severe obesity and selected risk factors in a sixth grade multiracial cohort: the HEALTHY study. J Adolesc Health. 2010; 47(6): 604-7[DOI][PubMed]
  • 29. Gomez-Ambrosi J, Catalan V, Ramirez B, Rodriguez A, Colina I, Silva C, et al. Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J Clin Endocrinol Metab. 2007; 92(9): 3719-27[DOI][PubMed]
  • 30. Ahmad R, Al-Mass A, Al-Ghawas D, Shareif N, Zghoul N, Melhem M, et al. Interaction of osteopontin with IL-18 in obese individuals: implications for insulin resistance. PLoS One. 2013; 8(5)[DOI][PubMed]
  • 31. Speiser PW, Rudolf MC, Anhalt H, Camacho-Hubner C, Chiarelli F, Eliakim A, et al. Childhood obesity. J Clin Endocrinol Metab. 2005; 90(3): 1871-87[DOI][PubMed]
  • 32. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology. 1999; 116(6): 1413-9[PubMed]
  • 33. Zhang H, Yang H, Lai C, Xu X, Huang K, Fu J. Quantitative relationship between liver fat content and metabolic syndrome in obese children and adolescents. Clin Endocrinol (Oxf). 2015; 83(1): 43-9[DOI][PubMed]
  • 34. Huang JS, Barlow SE, Quiros-Tejeira RE, Scheimann A, Skelton J, Suskind D, et al. Childhood obesity for pediatric gastroenterologists. J Pediatr Gastroenterol Nutr. 2013; 56(1): 99-109[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments