Iranian Journal of Pediatrics

Published by: Kowsar

The Effect of Probiotics in Prevention of Necrotising Enterocolitis in Preterm Neonates in Comparison with Control Group

Elaheh Amini 1 , Hosein Dalili 2 , Nikoo Niknafs 1 , Mamak Shariat 3 , Maryam Nakhostin 4 and Saeid Jedari-Attari 1 , *
Authors Information
1 Neonatologist, Maternal-Fetal and Neonatal Research Center
2 Neonatologist, Breastfeeding Research Center, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Maternal and Child Health Specialist, Maternal, Fetal and Neonatal Research Center
4 MD, Breastfeeding Research Center, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Iranian Journal of Pediatrics: December 2017, 27 (6); e7663
  • Published Online: October 22, 2017
  • Article Type: Research Article
  • Received: June 25, 2016
  • Revised: August 8, 2016
  • Accepted: June 29, 2017
  • DOI: 10.5812/ijp.7663

To Cite: Amini E, Dalili H, Niknafs N, Shariat M, Nakhostin M, et al. The Effect of Probiotics in Prevention of Necrotising Enterocolitis in Preterm Neonates in Comparison with Control Group, Iran J Pediatr. 2017 ; 27(6):e7663. doi: 10.5812/ijp.7663.

Copyright © 2017, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Szajewska H. Probiotics and prebiotics in preterm infants: where are we? Where are we going? Early Hum Dev. 2010; 86 Suppl 1: 81-6[DOI][PubMed]
  • 2. Cloherty JP, Eichenwald EC, Stark AR. Manual of neonatal care. 2008;
  • 3. Patel RM, Denning PW. Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: what is the current evidence? Clin Perinatol. 2013; 40(1): 11-25[DOI][PubMed]
  • 4. Neu J, Young CM, Mai V. Avery's Diseases of the Newborn. 2012; : 1016-21
  • 5. Yoshioka H, Iseki K, Fujita K. Development and differences of intestinal flora in the neonatal period in breast-fed and bottle-fed infants. Pediatrics. 1983; 72(3): 317-21[PubMed]
  • 6. Pietzak M. Bacterial colonization of the neonatal gut. J Pediatr Gastroenterol Nutr. 2004; 38(4): 389-91[PubMed]
  • 7. Gewolb IH, Schwalbe RS, Taciak VL, Harrison TS, Panigrahi P. Stool microflora in extremely low birthweight infants. Arch Dis Child Fetal Neonatal Ed. 1999; 80(3)-73[PubMed]
  • 8. Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006; 118(2): 511-21[DOI][PubMed]
  • 9. Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics. 2010; 125(5): 921-30[DOI][PubMed]
  • 10. Ladd N, Ngo T. The use of probiotics in the prevention of necrotizing enterocolitis in preterm infants. Proc (Bayl Univ Med Cent). 2009; 22(3): 287-91[PubMed]
  • 11. Fernandez-Carrocera LA, Solis-Herrera A, Cabanillas-Ayon M, Gallardo-Sarmiento RB, Garcia-Perez CS, Montano-Rodriguez R, et al. Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis. Arch Dis Child Fetal Neonatal Ed. 2013; 98(1)-9[DOI][PubMed]
  • 12. Grave L. The use of probiotics in preventing NEC. 2011;
  • 13. Fanaroff AAM, Fanaroff RA, Martin RJ. Neonatal-perinatal medicine: diseases of the fetus and infant. 2002;
  • 14. Alfaleh K, Anabrees J, Bassler D, Al-Kharfi T. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2011; (3)[DOI][PubMed]
  • 15. Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr. 2005; 147(2): 192-6[DOI][PubMed]
  • 16. Costalos C, Skouteri V, Gounaris A, Sevastiadou S, Triandafilidou A, Ekonomidou C, et al. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum Dev. 2003; 74(2): 89-96[PubMed]
  • 17. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate. 2002; 82(2): 103-8[PubMed]
  • 18. Kitajima H, Sumida Y, Tanaka R, Yuki N, Takayama H, Fujimura M. Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 1997; 76(2)-7[PubMed]
  • 19. Li Y, Shimizu T, Hosaka A, Kaneko N, Ohtsuka Y, Yamashiro Y. Effects of bifidobacterium breve supplementation on intestinal flora of low birth weight infants. Pediatr Int. 2004; 46(5): 509-15[DOI][PubMed]
  • 20. Lin HC, Su BH, Chen AC, Lin TW, Tsai CH, Yeh TF, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2005; 115(1): 1-4[DOI][PubMed]
  • 21. Manzoni P, Mostert M, Leonessa ML, Priolo C, Farina D, Monetti C, et al. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis. 2006; 42(12): 1735-42[DOI][PubMed]
  • 22. Millar MR, Bacon C, Smith SL, Walker V, Hall MA. Enteral feeding of premature infants with Lactobacillus GG. Arch Dis Child. 1993; 69(5 Spec No): 483-7[PubMed]
  • 23. Reuman PD, Duckworth DH, Smith KL, Kagan R, Bucciarelli RL, Ayoub EM. Lack of effect of Lactobacillus on gastrointestinal bacterial colonization in premature infants. Pediatr Infect Dis. 1986; 5(6): 663-8[PubMed]
  • 24. Deshpande GC, Rao SC, Keil AD, Patole SK. Evidence-based guidelines for use of probiotics in preterm neonates. BMC Med. 2011; 9: 92[DOI][PubMed]
  • 25. Commane DM, Shortt CT, Silvi S, Cresci A, Hughes RM, Rowland IR. Effects of fermentation products of pro- and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer. 2005; 51(1): 102-9[DOI][PubMed]
  • 26. Falony G, Vlachou A, Verbrugghe K, De Vuyst L. Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol. 2006; 72(12): 7835-41[DOI][PubMed]
  • 27. Bjorksten B, Naaber P, Sepp E, Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999; 29(3): 342-6[PubMed]
  • 28. Thomas DW, Greer FR, American Academy of Pediatrics Committee on N, American Academy of Pediatrics Section on Gastroenterology H. Probiotics and prebiotics in pediatrics. Pediatrics. 2010; 126(6): 1217-31[DOI][PubMed]
  • 29. Kliegman RM. The relationship of neonatal feeding practices and the pathogenesis and prevention of necrotizing enterocolitis. Pediatrics. 2003; 111(3): 671-2[PubMed]
  • 30. Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, et al. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009; 123(1): 58-66[DOI][PubMed]
  • 31. Li D, Rosito G, Slagle T. Probiotics for the prevention of necrotizing enterocolitis in neonates: an 8-year retrospective cohort study. J Clin Pharm Ther. 2013; 38(6): 445-9[DOI]
  • 32. Crittenden R, Bird AR, Gopal P, Henriksson A, Lee YK, Playne MJ. Probiotic research in Australia, New Zealand and the Asia-Pacific region. Curr Pharm Des. 2005; 11(1): 37-53[PubMed]

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments