Iranian Journal of Pediatrics

Published by: Kowsar

Probiotics for Prophylaxis and Treatment of Urinary Tract Infections in Children

Ilke Beyitler 1 , * and Salih Kavukcu 1
Authors Information
1 Department of Pediatrics, Near East University Hospital, Nicosia, Cyprus
Article information
  • Iranian Journal of Pediatrics: April 2017, 27 (2); e7695
  • Published Online: October 22, 2016
  • Article Type: Review Article
  • Received: June 28, 2016
  • Accepted: September 30, 2016
  • DOI: 10.5812/ijp.7695

To Cite: Beyitler I, Kavukcu S. Probiotics for Prophylaxis and Treatment of Urinary Tract Infections in Children, Iran J Pediatr. 2017 ; 27(2):e7695. doi: 10.5812/ijp.7695.

Copyright © 2016, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Mechanisms Behind Action
4. Trials on the Current Concept
5. Recommended Dosages and Duration
6. Conclusion
  • 1. Madden-Fuentes RJ, Arshad M, Ross SS, Seed PC. Efficacy of Fluoroquinolone/Probiotic Combination Therapy for Recurrent Urinary Tract Infection in Children: A Retrospective Analysis. Clin Ther. 2015; 37(9): 2143-7[DOI][PubMed]
  • 2. Borchert D, Sheridan L, Papatsoris A, Faruquz Z, Barua JM, Junaid I, et al. Prevention and treatment of urinary tract infection with probiotics: Review and research perspective. Indian J Urol. 2008; 24(2): 139-44[PubMed]
  • 3. Amdekar S, Singh V, Singh DD. Probiotic therapy: immunomodulating approach toward urinary tract infection. Curr Microbiol. 2011; 63(5): 484-90[DOI][PubMed]
  • 4. Singhi SC, Kumar S. Probiotics in critically ill children. F1000Research. 2016; 5: 407[DOI]
  • 5. Chapman CM, Gibson GR, Rowland I. Effects of single- and multi-strain probiotics on biofilm formation and in vitro adhesion to bladder cells by urinary tract pathogens. Anaerobe. 2014; 27: 71-6[DOI][PubMed]
  • 6. Lee SJ, Shim YH, Cho SJ, Lee JW. Probiotics prophylaxis in children with persistent primary vesicoureteral reflux. Pediatr Nephrol. 2007; 22(9): 1315-20[DOI][PubMed]
  • 7. Storm DW, Patel AS, Koff SA, Justice SS. Novel management of urinary tract infections. Curr Opin Urol. 2011; 21(4): 328-33[DOI][PubMed]
  • 8. Cadieux PA, Burton J, Devillard E, Reid G. Lactobacillus by-products inhibit the growth and virulence of uropathogenic Escherichia coli. J Physiol Pharmacol. 2009; 60 Suppl 6: 13-8[PubMed]
  • 9. Anukam KC, Hayes K, Summers K, Reid G. ProbioticLactobacillus rhamnosusGR-1 andLactobacillus reuteriRC-14 May Help Downregulate TNF-Alpha, IL-6, IL-8, IL-10 and IL-12 (p70) in the Neurogenic Bladder of Spinal Cord Injured Patient with Urinary Tract Infections: A Two-Case Study. Adv Urol. 2009; 2009: 1-5[DOI]
  • 10. Olivares M, Diaz-Ropero MP, Gomez N, Lara-Villoslada F, Sierra S, Maldonado JA, et al. The consumption of two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, boosts the immune system of healthy humans. Int Microbiol. 2006; 9(1): 47-52[PubMed]
  • 11. Karlsson M, Scherbak N, Khalaf H, Olsson PE, Jass J. Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-kappaB activity in Escherichia coli-stimulated urinary bladder cells. FEMS Immunol Med Microbiol. 2012; 66(2): 147-56[DOI][PubMed]
  • 12. Delley M, Bruttin A, Richard M, Affolter M, Rezzonico E, Brück WM, et al. In vitroactivity of commercial probioticLactobacillusstrains against uropathogenicEscherichia coli. FEMS Microbiology Letters. 2015; 362(13): 96[DOI]
  • 13. Anukam K, Osazuwa E, Ahonkhai I, Ngwu M, Osemene G, Bruce AW, et al. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 2006; 8(6): 1450-4[DOI][PubMed]
  • 14. Marild S, Hansson S, Jodal U, Oden A, Svedberg K. Protective effect of breastfeeding against urinary tract infection. Acta Paediatr. 2004; 93(2): 164-8[PubMed]
  • 15. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate. 2002; 82(2): 103-8[PubMed]
  • 16. Gerasimov SV. Probiotic Prophylaxis in Pediatric Recurrent Urinary Tract Infections. Clin Ped. 2004; 43(1): 95-8[DOI]
  • 17. Reid G, Bruce AW, Fraser N, Heinemann C, Owen J, Henning B. Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol. 2001; 30(1): 49-52[PubMed]
  • 18. Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012; 172(9): 704-12[DOI][PubMed]
  • 19. Mohseni MJ, Aryan Z, Emamzadeh-Fard S, Paydary K, Mofid V, Joudaki H, et al. Combination of probiotics and antibiotics in the prevention of recurrent urinary tract infection in children. Iran J Pediatr. 2013; 23(4): 430-8[PubMed]
  • 20. Naderi A, Kasra-Kermanshahi R, Gharavi S, Imani Fooladi AA, Abdollahpour Alitappeh M, Saffarian P. Study of antagonistic effects of Lactobacillus strains as probiotics on multi drug resistant (MDR) bacteria isolated from urinary tract infections (UTIs). Iran J Basic Med Sci. 2014; 17(3): 201-8[PubMed]
  • 21. Kumar S, Singhi S, Chakrabarti A, Bansal A, Jayashree M. Probiotic use and prevalence of candidemia and candiduria in a PICU. Pediatr Crit Care Med. 2013; 14(9): 409-15[DOI][PubMed]
  • 22. Akil I, Yilmaz O, Kurutepe S, Degerli K, Kavukcu S. Influence of oral intake of Saccharomyces boulardii on Escherichia coli in enteric flora. Pediatr Nephrol. 2006; 21(6): 807-10[DOI][PubMed]
  • 23. Lee SJ, Cha J, Lee JW. Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts. World Journal of Pediatrics. 2016; [DOI]
  • 24. Tommasi C, Equitani F, Masala M, Ballardini M, Favaro M, Meledandri M, et al. Diagnostic difficulties of Lactobacillus casei bacteraemia in immunocompetent patients: a case report. J Med Case Rep. 2008; 2: 315[DOI][PubMed]
  • 25. Dani C, Coviello CC, Corsini II, Arena F, Antonelli A, Rossolini GM. Lactobacillus Sepsis and Probiotic Therapy in Newborns: Two New Cases and Literature Review. AJP Rep. 2016; 6(1): 25-9[DOI][PubMed]
  • 26. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology. 2015; 107(1): 56-9[DOI][PubMed]
  • 27. Stefanatou E, Kompoti M, Paridou A, Koutsodimitropoulos I, Giannopoulou P, Markou N, et al. Probiotic sepsis due to Saccharomyces fungaemia in a critically ill burn patient. Mycoses. 2011; 54(5): 643-6[DOI][PubMed]
  • 28. Kligler B, Cohrssen A. Probiotics. Am Fam Physician. 2008; 78(9): 1073-8[PubMed]
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