Iranian Journal of Pediatrics

Published by: Kowsar

Rapid Etiologic Diagnosis of Herpes Virus Infections in Children

Yujie Liu 1 , Yidong Wu 2 , Xiaoting Shen 1 , Huihui Gao 1 , Wei Li 1 and Shiqiang Shang 1 , *
Authors Information
1 Department of Clinical Laboratory, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou 310003, PR China
2 Department of Clinical Laboratory, Hangzhou Children’s Hospital
Article information
  • Iranian Journal of Pediatrics: April 2017, 27 (2); e7992
  • Published Online: January 15, 2017
  • Article Type: Research Article
  • Received: July 24, 2016
  • Revised: April 12, 2016
  • Accepted: November 26, 2016
  • DOI: 10.5812/ijp.7992

To Cite: Liu Y, Wu Y, Shen X, Gao H, Li W, et al. Rapid Etiologic Diagnosis of Herpes Virus Infections in Children, Iran J Pediatr. 2017 ; 27(2):e7992. doi: 10.5812/ijp.7992.

Copyright © 2017, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Goderis J, Keymeulen A, Smets K, Van Hoecke H, De Leenheer E, Boudewyns A, et al. Hearing in Children with Congenital Cytomegalovirus Infection: Results of a Longitudinal Study. J Pediatr. 2016; 172: 110-115 e2[DOI][PubMed]
  • 2. Park JH, Yoon DH, Kim S, Park JS, Park CS, Sung H, et al. Pretreatment whole blood Epstein-Barr virus-DNA is a significant prognostic marker in patients with Hodgkin lymphoma. Ann Hematol. 2016; 95(5): 801-8[DOI][PubMed]
  • 3. Saraya AW, Wacharapluesadee S, Petcharat S, Sittidetboripat N, Ghai S, Wilde H, et al. Normocellular CSF in herpes simplex encephalitis. BMC Res Notes. 2016; 9: 95[DOI][PubMed]
  • 4. Katzenell S, Leib DA. Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons. J Virol. 2016; 90(9): 4706-19[DOI][PubMed]
  • 5. Liu T, Zheng X, Li Q, Chen J, Yin Z, Xiao J, et al. Role of human cytomegalovirus in the proliferation and invasion of extravillous cytotrophoblasts isolated from early placentae. Int J Clin Exp Med. 2015; 8(10): 17248-60[PubMed]
  • 6. Xing Y, Oliver SL, Nguyen T, Ciferri C, Nandi A, Hickman J, et al. A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL. Proc Natl Acad Sci U S A. 2015; 112(19): 6056-61[DOI][PubMed]
  • 7. Jansen MA, van den Heuvel D, Bouthoorn SH, Jaddoe VW, Hooijkaas H, Raat H, et al. Determinants of Ethnic Differences in Cytomegalovirus, Epstein-Barr Virus, and Herpes Simplex Virus Type 1 Seroprevalence in Childhood. J Pediatr. 2016; 170: 126-34 e1-6[DOI][PubMed]
  • 8. Ueda S, Uchiyama S, Azzi T, Gysin C, Berger C, Bernasconi M, et al. Oropharyngeal group A streptococcal colonization disrupts latent Epstein-Barr virus infection. J Infect Dis. 2014; 209(2): 255-64[DOI][PubMed]
  • 9. Lang D, Vornhagen R, Rothe M, Hinderer W, Sonneborn HH, Plachter B. Cross-reactivity of Epstein-Barr virus-specific immunoglobulin M antibodies with cytomegalovirus antigens containing glycine homopolymers. Clin Diagn Lab Immunol. 2001; 8(4): 747-56[DOI][PubMed]
  • 10. Zidane N, Dussart P, Bremand L, Bedouelle H. Cross-reactivities between human IgMs and the four serotypes of dengue virus as probed with artificial homodimers of domain-III from the envelope proteins. BMC Infect Dis. 2013; 13: 302[DOI][PubMed]
  • 11. Yeh HY, Yates MV, Chen W, Mulchandani A. Real-time molecular methods to detect infectious viruses. Semin Cell Dev Biol. 2009; 20(1): 49-54[DOI][PubMed]
  • 12. Mannonen L, Vainionpaa R, Kauppinen J, Lienhard R, Tritten ML, Cannon G, et al. Evaluation of multiplex polymerase chain reaction and microarray-based assay for rapid herpesvirus diagnostics. Diagn Microbiol Infect Dis. 2012; 73(1): 74-9[DOI][PubMed]
  • 13. Zheng ZB, Wu YD, Yu XL, Shang SQ. DNA microarray technology for simultaneous detection and species identification of seven human herpes viruses. J Med Virol. 2008; 80(6): 1042-50[DOI][PubMed]
  • 14. Shi J, Wu Y, Cai M, Shang S. Rapid diagnosis of herpetic encephalitis in children by PCR-microarray technology for simultaneous detection of seven human herpes viruses. Eur J Pediatr. 2010; 169(4): 421-5[DOI][PubMed]
  • 15. Soares BP, Provenzale JM. Imaging of Herpesvirus Infections of the CNS. AJR Am J Roentgenol. 2016; 206(1): 39-48[DOI][PubMed]
  • 16. Liu Y, Duan C, Zhang C, Yang X, Zhao Y, Dong R, et al. Evaluation of a viral microarray based on simultaneous extraction and amplification of viral nucleotide acid for detecting human herpesviruses and enteroviruses. PLoS One. 2015; 10(3)[DOI][PubMed]
  • 17. Balfour HJ, Dunmire SK, Hogquist KA. Infectious mononucleosis. Clin Transl Immunology. 2015; 4(2)[DOI][PubMed]
  • 18. Carvalho-Queiroz C, Johansson MA, Persson JO, Jortso E, Kjerstadius T, Nilsson C, et al. Associations between EBV and CMV Seropositivity, Early Exposures, and Gut Microbiota in a Prospective Birth Cohort: A 10-Year Follow-up. Front Pediatr. 2016; 4: 93[DOI][PubMed]
  • 19. Navari M, Fuligni F, Laginestra MA, Etebari M, Ambrosio MR, Sapienza MR, et al. Molecular signature of Epstein Barr virus-positive Burkitt lymphoma and post-transplant lymphoproliferative disorder suggest different roles for Epstein Barr virus. Front Microbiol. 2014; 5: 728[DOI][PubMed]
  • 20. Ansari MA, Singh VV, Dutta S, Veettil MV, Dutta D, Chikoti L, et al. Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells. J Virol. 2013; 87(15): 8606-23[DOI][PubMed]
  • 21. Wu SE, Miller WE. The human cytomegalovirus lytic cycle is induced by 1,25-dihydroxyvitamin D3 in peripheral blood monocytes and in the THP-1 monocytic cell line. Virology. 2015; 483: 83-95[DOI][PubMed]
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