Evaluation of Oxidative Stress and Erythrocyte Properties in Children with Henoch-Shoenlein Purpura
Iranian Journal of Pediatrics: April 30, 2014, 24 (2); 166-172
February 06, 2014
Article Type: Research Article
June 25, 2013
January 23, 2014
D , Parlaz
N , Bor-Kucukatay
G. et al. Evaluation of Oxidative Stress and Erythrocyte Properties in Children with Henoch-Shoenlein Purpura,
Iran J Pediatr.
Objective: Pathogenesis of Henoch-Schönlein purpura (HSP) is not clearly defined. The present study was conducted to investigate the alterations in erythrocyte deformability and oxidative stress in HSP and to examine the possible relationship between erythrocyte deformability and organ involvement in this disease.
Methods: Plasma malondialdehyde (MDA) levels, total antioxidant status (TAS), erythrocyte deformability and aggregation were measured in 21 children with HSP at the disease onset and during the remission period in comparison with healthy subjects.
Findings: HSP patients at the active stage had significantly higher MDA and lower TAS levels (P<0.05). Erythrocyte deformability was decreased at the active-stage and increased again at the remission period of HSP (P<0.05). Erythrocyte deformability was significantly decreased at four different shear stresses in patients with gastrointestinal system or renal involvement; and decreased at six different shear stresses in patients with gastrointestinal system, and renal involvement compared to the patients without organ involvement (P<0.05). No significant difference was observed in aggregation parameters (P>0.05).
Conclusion: The present findings emphasize the association between impaired erythrocyte deformability and organ involvement in HSP.
Erythrocyte Aggregation; Erythrocyte Deformability; Henoch-Schönlein Purpura; Malondialdehyde; Oxidative Stress
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