Iranian Journal of Pediatrics

Published by: Kowsar

Salivary Tumor Necrosis Factor-Alpha and Dental Caries in Children and Adolescents

Bahareh Nazemisalman 1 , Faezeh Jafari 2 , Abdolreza Esmaelzadeh 3 , Soghrat Faghihzadeh 4 , Surena Vahabi 5 , * and Hamidreza Moslemi 6
Authors Information
1 Department of Pedodontics, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
2 Dentist, Zanjan, Iran
3 Zanjan Metabolic Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
4 Department of Statistics and Epidemiology, Zanjan University of Medical Sciences, Zanjan, Iran
5 Periodontics Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Article information
  • Iranian Journal of Pediatrics: 29 (1); e80899
  • Published Online: December 11, 2018
  • Article Type: Research Article
  • Received: June 16, 2018
  • Revised: October 8, 2018
  • Accepted: October 15, 2018
  • DOI: 10.5812/ijp.80899

To Cite: Nazemisalman B, Jafari F , Esmaelzadeh A, Faghihzadeh S, Vahabi S, et al. Salivary Tumor Necrosis Factor-Alpha and Dental Caries in Children and Adolescents, Iran J Pediatr. Online ahead of Print ; 29(1):e80899. doi: 10.5812/ijp.80899.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Caufield PW, Griffen AL. Dental caries. An infectious and transmissible disease. Pediatr Clin North Am. 2000;47(5):1001-19. v. doi: 10.1016/S0031-3955(05)70255-8. [PubMed: 11059347].
  • 2. Featherstone JD. The continuum of dental caries--evidence for a dynamic disease process. J Dent Res. 2004;83 Spec No C:C39-42. [PubMed: 15286120].
  • 3. Smith DJ. Dental caries vaccines: Prospects and concerns. Crit Rev Oral Biol Med. 2002;13(4):335-49. doi: 10.1177/154411130201300404. [PubMed: 12191960].
  • 4. Selwitz RH, Ismail AI, Pitts NB. Dental caries. Lancet. 2007;369(9555):51-9. doi: 10.1016/S0140-6736(07)60031-2. [PubMed: 17208642].
  • 5. Shifa S, Muthu MS, Amarlal D, Rathna Prabhu V. Quantitative assessment of IgA levels in the unstimulated whole saliva of caries-free and caries-active children. J Indian Soc Pedod Prev Dent. 2008;26(4):158-61. doi: 10.4103/0970-4388.44031. [PubMed: 19008624].
  • 6. Lenander-Lumikari M, Loimaranta V. Saliva and dental caries. Adv Dent Res. 2000;14:40-7. doi: 10.1177/08959374000140010601. [PubMed: 11842922].
  • 7. Lencova E, Broukal Z, Spizek J. Point-of-care salivary microbial tests for detection of cariogenic species--clinical relevance thereof--review. Folia Microbiol (Praha). 2010;55(6):559-68. doi: 10.1007/s12223-010-0090-x. [PubMed: 21253899].
  • 8. Martins C, Buczynski AK, Maia LC, Siqueira WL, Castro GF. Salivary proteins as a biomarker for dental caries--a systematic review. J Dent. 2013;41(1):2-8. doi: 10.1016/j.jdent.2012.10.015. [PubMed: 23142096].
  • 9. Zhao A, Blackburn C, Chin J, Srinivasan M. Soluble toll like receptor 2 (TLR-2) is increased in saliva of children with dental caries. BMC Oral Health. 2014;14:108. doi: 10.1186/1472-6831-14-108. [PubMed: 25174416]. [PubMed Central: PMC4236648].
  • 10. Dodds MW, Johnson DA, Yeh CK. Health benefits of saliva: A review. J Dent. 2005;33(3):223-33. doi: 10.1016/j.jdent.2004.10.009. [PubMed: 15725522].
  • 11. Van Nieuw Amerongen A, Bolscher JG, Veerman EC. Salivary proteins: Protective and diagnostic value in cariology? Caries Res. 2004;38(3):247-53. doi: 10.1159/000077762. [PubMed: 15153696].
  • 12. Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, et al. Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A. 2011;108(20):8402-7. doi: 10.1073/pnas.1019437108. [PubMed: 21536877]. [PubMed Central: PMC3100978].
  • 13. Shapiro H, Lutaty A, Ariel A. Macrophages, meta-inflammation, and immuno-metabolism. ScientificWorldJournal. 2011;11:2509-29. doi: 10.1100/2011/397971. [PubMed: 22235182]. [PubMed Central: PMC3253544].
  • 14. De Paepe B, Creus KK, De Bleecker JL. The tumor necrosis factor superfamily of cytokines in the inflammatory myopathies: Potential targets for therapy. Clin Dev Immunol. 2012;2012:369432. doi: 10.1155/2012/369432. [PubMed: 22110532]. [PubMed Central: PMC3202109].
  • 15. Slattery ML, Lundgreen A, Bondurant KL, Wolff RK. Tumor necrosis factor-related genes and colon and rectal cancer. Int J Mol Epidemiol Genet. 2011;2(4):328-38. [PubMed: 22199996]. [PubMed Central: PMC3243449].
  • 16. Guo L, Shi W. Salivary biomarkers for caries risk assessment. J Calif Dent Assoc. 2013;41(2):107-9. 112-8. [PubMed: 23505756]. [PubMed Central: PMC3825179].
  • 17. Fontana M, Zero DT. Assessing patients' caries risk. J Am Dent Assoc. 2006;137(9):1231-9. doi: 10.14219/jada.archive.2006.0380. [PubMed: 16946427].
  • 18. Cogulu D, Onay H, Ozdemir Y, I. Aslan G , Ozkinay F, Kutukculer N, et al. Associations of interleukin (IL)-1beta, IL-1 receptor antagonist, and IL-10 with dental caries. J Oral Sci. 2015;57(1):31-6. doi: 10.2334/josnusd.57.31. [PubMed: 25807906].
  • 19. Gornowicz A, Bielawska A, Bielawski K, Grabowska SZ, Wojcicka A, Zalewska M, et al. Pro-inflammatory cytokines in saliva of adolescents with dental caries disease. Ann Agric Environ Med. 2012;19(4):711-6. [PubMed: 23311795].
  • 20. Sharma V, Gupta N, Srivastava N, Rana V, Chandna P, Yadav S, et al. Diagnostic potential of inflammatory biomarkers in early childhood caries - A case control study. Clin Chim Acta. 2017;471:158-63. doi: 10.1016/j.cca.2017.05.037. [PubMed: 28579141].
  • 21. Ribeiro CCC, Pacheco CJB, Costa EL, Ladeira LLC, Costa JF, da Silva RA, et al. Proinflammatory cytokines in early childhood caries: Salivary analysis in the mother/children pair. Cytokine. 2018;107:113-7. doi: 10.1016/j.cyto.2017.12.009. [PubMed: 29246654].
  • 22. Costa SM, Martins CC, Bonfim Mde L, Zina LG, Paiva SM, Pordeus IA, et al. A systematic review of socioeconomic indicators and dental caries in adults. Int J Environ Res Public Health. 2012;9(10):3540-74. doi: 10.3390/ijerph9103540. [PubMed: 23202762]. [PubMed Central: PMC3509471].
  • 23. Do LG. Distribution of caries in children: Variations between and within populations. J Dent Res. 2012;91(6):536-43. doi: 10.1177/0022034511434355. [PubMed: 22223436].
  • 24. Benabdelmoumene S, Dumont S, Petit C, Poindron P, Wachsmann D, Klein JP. Activation of human monocytes by Streptococcus mutans serotype f polysaccharide: immunoglobulin G Fc receptor expression and tumor necrosis factor and interleukin-1 production. Infect Immun. 1991;59(9):3261-6. [PubMed: 1831797]. [PubMed Central: PMC258161].
  • 25. Pezelj-Ribaric S, Prso IB, Abram M, Glazar I, Brumini G, Simunovic-Soskic M. Salivary levels of tumor necrosis factor-alpha in oral lichen planus. Mediators Inflamm. 2004;13(2):131-3. doi: 10.1080/09629350410001688530. [PubMed: 15203556]. [PubMed Central: PMC1781548].
  • 26. SahebJamee M, Eslami M, AtarbashiMoghadam F, Sarafnejad A. Salivary concentration of TNFalpha, IL1 alpha, IL6, and IL8 in oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2008;13(5):E292-5. [PubMed: 18449112].
  • 27. Gornowicz A, Tokajuk G, Bielawska A, Maciorkowska E, Jablonski R, Wojcicka A, et al. The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries. Med Sci Monit. 2014;20:1095-100. doi: 10.12659/MSM.890468. [PubMed: 24974109]. [PubMed Central: PMC4087079].
  • 28. Ranadheer E, Nayak UA, Reddy NV, Rao VA. The relationship between salivary IgA levels and dental caries in children. J Indian Soc Pedod Prev Dent. 2011;29(2):106-12. doi: 10.4103/0970-4388.84681. [PubMed: 21911947].
  • 29. Madden KS, Felten DL. Experimental basis for neural-immune interactions. Physiol Rev. 1995;75(1):77-106. doi: 10.1152/physrev.1995.75.1.77. [PubMed: 7831399].
  • 30. Fagiolo U, Cossarizza A, Scala E, Fanales-Belasio E, Ortolani C, Cozzi E, et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol. 1993;23(9):2375-8. doi: 10.1002/eji.1830230950. [PubMed: 8370415].
  • 31. Rich EA, Mincek MA, Armitage KB, Duffy EG, Owen DC, Fayen JD, et al. Accessory function and properties of monocytes from healthy elderly humans for T lymphocyte responses to mitogen and antigen. Gerontology. 1993;39(2):93-108. doi: 10.1159/000213519. [PubMed: 8514204].
  • 32. Kamma J, Mombelli A, Tsinidou K, Vasdekis V, Giannopoulou C. Cytokines in gingival crevicular fluid of adolescents and young adults. Oral Microbiol Immunol. 2009;24(1):7-10. doi: 10.1111/j.1399-302X.2008.00466.x. [PubMed: 19121063].
  • 33. Mariotti A. Sex steroid hormones and cell dynamics in the periodontium. Crit Rev Oral Biol Med. 1994;5(1):27-53. doi: 10.1177/10454411940050010201. [PubMed: 7999949].
  • 34. Vittek J, Munnangi P, Gordon G, Rappaport S, Southren A. Progesterone receptors in human gingiva. IRCS Med Sci. 1982;10(5):381-4.

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