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A Randomized Clinical Trial of Insulin Glargine and Aspart, Compared to NPH and Regular Insulin in Children with Type 1 Diabetes Mellitus

AUTHORS

Aria Setoodeh 1 , * , Parastoo Rostami 2 , Ali Rabbani 3 , Maryam Nakhaei-Moghadam 4 , Farnaz Najmi-Varzaneh 5 , Nima Rezaei 6

AUTHORS INFORMATION

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How to Cite: Setoodeh A , Rostami P, Rabbani A, Nakhaei-Moghadam M, Najmi-Varzaneh F, et al. A Randomized Clinical Trial of Insulin Glargine and Aspart, Compared to NPH and Regular Insulin in Children with Type 1 Diabetes Mellitus, Iran J Pediatr. 2014 ; 24(2):173-178.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 24 (2); 173-178
Published Online: February 15, 2014
Article Type: Research Article
Received: February 24, 2013
Accepted: December 25, 2013

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Abstract

Objective: Appropriate treatment of patients with Type 1 diabetes mellitus (T1DM) is necessary to avoid further complications. This study was performed to compare the efficacy of insulin Glargine and Aspart with NPH insulin and regular insulin regimen in a group of children with T1DM. Methods: Forty patients with T1DM were enrolled in this study. During run-in, all subjects were treated with conventional therapy consisting of twice-daily NPH and thrice-daily regular. Following randomization, 20 subjects received Glargine and Aspart and 20 subjects received NPH and Regular insulin. Findings: Mean HbA1c was 8.8% and 8.6% at first and 8.4% and 8.2% at the end of study for subjects randomized initially to Glargine and Aspart and for those randomized to NPH and Regular, respectively (P>0.05). Mean fasting blood glucose (FBS) of the subjects randomized initially to Glargine and Aspart was 217±101 mg/dL, with no significant difference to 196±75 mg/dL for those randomized to NPH and Regular (P=0.48). This was also true at the end of the study. The difference in total cholesterol and triglyceride between the two groups in the beginning of study and at the end did not show any significance. Conclusion: The current study showed no significant difference in glycemic control [Glycated hemoglobin (HbA1c) and FBS] and lipid profile (total cholesterol and triglyceride) between two regimes.

 

Keywords

Type 1 Diabetes Mellitus Insulin Glargine Insulin Aspart Conventional Therapy

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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