Iranian Journal of Pediatrics

Published by: Kowsar

Utility of Lubiprostone for Japanese Children with Functional Constipation

Yoshimitsu Fujii 1 , * and Tetsuji Morimoto 1
Authors Information
1 Division of Pediatrics, Tohoku Medical and Pharmaceutical University, Sendai, Japan
Article information
  • Iranian Journal of Pediatrics: 29 (1); e81563
  • Published Online: January 14, 2019
  • Article Type: Case Report
  • Received: June 30, 2018
  • Revised: October 14, 2018
  • Accepted: November 13, 2018
  • DOI: 10.5812/ijp.81563

To Cite: Fujii Y, Morimoto T. Utility of Lubiprostone for Japanese Children with Functional Constipation, Iran J Pediatr. Online ahead of Print ; 29(1):e81563. doi: 10.5812/ijp.81563.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Li F, Fu T, Tong WD, Liu BH, Li CX, Gao Y, et al. Lubiprostone is effective in the treatment of chronic idiopathic constipation and irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials. Mayo Clin Proc. 2016;91(4):456-68. doi: 10.1016/j.mayocp.2016.01.015. [PubMed: 27046523].
  • 2. Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: A double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Aliment Pharmacol Ther. 2007;25(11):1351-61. doi: 10.1111/j.1365-2036.2007.03320.x. [PubMed: 17509103].
  • 3. Mearin F, Ciriza C, Minguez M, Rey E, Mascort JJ, Pena E, et al. Clinical practice guideline: Irritable bowel syndrome with constipation and functional constipation in the adult. Rev Esp Enferm Dig. 2016;108(6):332-63. doi: 10.17235/reed.2016.4389/2016. [PubMed: 27230827].
  • 4. Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition. Guideline of pediatric chronic functional constipation treatment (Japanese). 2013. Japanese. Available from:
  • 5. Hyman PE, Di Lorenzo C, Prestridge LL, Youssef NN, Ueno R. Lubiprostone for the treatment of functional constipation in children. J Pediatr Gastroenterol Nutr. 2014;58(3):283-91. doi: 10.1097/MPG.0000000000000176. [PubMed: 24048162].
  • 6. Fujii Y, Yamanouchi S, Kato S. [Usefulness of the bristol stool form scale in the diagnosis and the severity assessment of pediatric functional constipation]. J Jpn Pediatr Soc. 2014;118:791-6. Japanese.
  • 7. Abe T, Hachiro Y, Ebisawa Y, Hishiyama H, Murakami M, Kunimoto M. Efficacy of itopride in the prevention of lubiprostone-induced nausea. Open J Gastroenterol. 2014;4(9):305. doi: 10.4236/ojgas.2014.49044.

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