Iranian Journal of Pediatrics

Published by: Kowsar

The Relationship of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Gastrointestinal Bleeding in Henoch-Schonlein Purpura

Ozlem Bostan Gayret 1 , * , Meltem Erol 1 and Hikmet Tekin Nacaroglu 2
Authors Information
1 Bagcilar Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey
2 Bagcilar Training and Research Hospital, Department of Pediatric Allergy, Istanbul, Turkey
Article information
  • Iranian Journal of Pediatrics: October 2016, 26 (5); e8191
  • Published Online: October 10, 2016
  • Article Type: Research Article
  • Received: August 9, 2016
  • Revised: September 6, 2016
  • Accepted: October 1, 2016
  • DOI: 10.5812/ijp.8191

To Cite: Gayret O B, Erol M, Tekin Nacaroglu H. The Relationship of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Gastrointestinal Bleeding in Henoch-Schonlein Purpura, Iran J Pediatr. 2016 ;26(5):e8191. doi: 10.5812/ijp.8191.

Abstract
Copyright: Copyright © 2016, Iranian Journal of Pediatrics. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
Footnotes
References
  • 1. Saulsbury FT. Clinical update: Henoch-Schonlein purpura. Lancet. 2007; 369(9566): 976-8[DOI][PubMed]
  • 2. Barut K, Sahin S, Adrovic A, Kasapcopur O. Diagnostic approach and current treatment options in childhood vasculitis. Turk Pediatri Ars. 2015; 50(4): 194-205[DOI][PubMed]
  • 3. Pohl M. Henoch-Schonlein purpura nephritis. Pediatr Nephrol. 2015; 30(2): 245-52[DOI][PubMed]
  • 4. Calvino MC, Llorca J, Garcia-Porrua C, Fernandez-Iglesias JL, Rodriguez-Ledo P, Gonzalez-Gay MA. Henoch-Schonlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study. Medicine (Baltimore). 2001; 80(5): 279-90[PubMed]
  • 5. Trapani S, Micheli A, Grisolia F, Resti M, Chiappini E, Falcini F, et al. Henoch Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature. Semin Arthritis Rheum. 2005; 35(3): 143-53[DOI][PubMed]
  • 6. Cull DL, Rosario V, Lally KP, Ratner I, Mahour GH. Surgical implications of Henoch-Schonlein purpura. J Pediatr Surg. 1990; 25(7): 741-3[PubMed]
  • 7. Trnka P. Henoch-Schonlein purpura in children. J Paediatr Child Health. 2013; 49(12): 995-1003[DOI][PubMed]
  • 8. Saulsbury FT, Kesler RW. Thrombocytosis in Henoch-Schonlein purpura. Clin Pediatr (Phila). 1983; 22(3): 185-7[PubMed]
  • 9. Lin SJ, Huang JL, Hsieh KH. Clinical and laboratory correlation of acute Henoch-Schonlein purpura in children. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1998; 39(2): 94-8[PubMed]
  • 10. Makay B, Gucenmez OA, Duman M, Unsal E. The relationship of neutrophil-to-lymphocyte ratio with gastrointestinal bleeding in Henoch-Schonlein purpura. Rheumatol Int. 2014; 34(9): 1323-7[DOI][PubMed]
  • 11. Tanoglu A, Karagoz E. Predictive role of neutrophil to lymphocyte ratio in Henoch-Schonlein purpura related gastrointestinal bleeding. Rheumatol Int. 2014; 34(9): 1331-2[DOI][PubMed]
  • 12. Balta S, Demirkol S, Kucuk U. The platelet lymphocyte ratio may be useful inflammatory indicator in clinical practice. Hemodial Int. 2013; 17(4): 668-9[DOI][PubMed]
  • 13. Ozen S, Ruperto N, Dillon MJ, Bagga A, Barron K, Davin JC, et al. EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides. Ann Rheum Dis. 2006; 65(7): 936-41[DOI][PubMed]
  • 14. de Almeida JL, Campos LM, Paim LB, Leone C, Koch VH, Silva CA. Renal involvement in Henoch-Schonlein purpura: a multivariate analysis of initial prognostic factors. J Pediatr (Rio J). 2007; 83(3): 259-66[DOI][PubMed]
  • 15. Wang D, Yang JX, Cao DY, Wan XR, Feng FZ, Huang HF, et al. Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther. 2013; 6: 211-6[DOI][PubMed]
  • 16. Park CH, Han DS, Jeong JY, Eun CS, Yoo KS, Jeon YC, et al. The Optimal Cut-Off Value of Neutrophil-to-Lymphocyte Ratio for Predicting Prognosis in Adult Patients with Henoch-Schonlein Purpura. PLoS One. 2016; 11(4): 153238[DOI][PubMed]
  • 17. Besbas N, Saatci U, Ruacan S, Ozen S, Sungur A, Bakkaloglu A, et al. The role of cytokines in Henoch Schonlein purpura. Scand J Rheumatol. 1997; 26(6): 456-60[PubMed]
  • 18. Ha TS. The role of tumor necrosis factor-alpha in Henoch-Schonlein purpura. Pediatr Nephrol. 2005; 20(2): 149-53[DOI][PubMed]
  • 19. Sen BB, Rifaioglu EN, Ekiz O, Inan MU, Sen T, Sen N. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol. 2014; 33(3): 223-7[DOI][PubMed]
  • 20. Fu H, Qin B, Hu Z, Ma N, Yang M, Wei T, et al. Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015; 61(3-4): 269-73[PubMed]
  • 21. Uslu AU, Kucuk A, Sahin A, Ugan Y, Yilmaz R, Gungor T, et al. Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Int J Rheum Dis. 2015; 18(7): 731-5[DOI][PubMed]
  • 22. Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med. 1999; 27(7): 1230-51[PubMed]
  • 23. Feng JF, Huang Y, Chen QX. Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma. World J Surg Oncol. 2014; 12: 58[DOI][PubMed]
  • 24. Templeton AJ, Ace O, McNamara MG, Al-Mubarak M, Vera-Badillo FE, Hermanns T, et al. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2014; 23(7): 1204-12[DOI][PubMed]
  • 25. Yildiz A, Yuksel M, Oylumlu M, Polat N, Akyuz A, Acet H, et al. The Utility of the Platelet-Lymphocyte Ratio for Predicting No Reflow in Patients With ST-Segment Elevation Myocardial Infarction. Clin Appl Thromb Hemost. 2015; 21(3): 223-8[DOI][PubMed]
  • 26. Azab B, Shah N, Akerman M, McGinn JJ. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis. 2012; 34(3): 326-34[DOI][PubMed]
  • 27. Gary T, Pichler M, Belaj K, Hafner F, Gerger A, Froehlich H, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS One. 2013; 8(7): 67688[DOI][PubMed]
  • 28. Wu Y, Chen Y, Yang X, Chen L, Yang Y. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. Int Immunopharmacol. 2016; 36: 94-9[DOI][PubMed]
  • 29. Ronkainen J, Koskimies O, Ala-Houhala M, Antikainen M, Merenmies J, Rajantie J, et al. Early prednisone therapy in Henoch-Schonlein purpura: a randomized, double-blind, placebo-controlled trial. J Pediatr. 2006; 149(2): 241-7[DOI][PubMed]
  • 30. Weiss PF, Klink AJ, Localio R, Hall M, Hexem K, Burnham JM, et al. Corticosteroids may improve clinical outcomes during hospitalization for Henoch-Schonlein purpura. Pediatrics. 2010; 126(4): 674-81[DOI][PubMed]
  • 31. Jauhola O, Ronkainen J, Koskimies O, Ala-Houhala M, Arikoski P, Holtta T, et al. Outcome of Henoch-Schonlein purpura 8 years after treatment with a placebo or prednisone at disease onset. Pediatr Nephrol. 2012; 27(6): 933-9[DOI][PubMed]
  • 32. Kaser A, Brandacher G, Steurer W, Kaser S, Offner FA, Zoller H, et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood. 2001; 98(9): 2720-5[PubMed]
  • 33. van Gameren MM, Willemse PH, Mulder NH, Limburg PC, Groen HJ, Vellenga E, et al. Effects of recombinant human interleukin-6 in cancer patients: a phase I-II study. Blood. 1994; 84(5): 1434-41[PubMed]
  • 34. Lin CY, Yang YH, Lee CC, Huang CL, Wang LC, Chiang BL. Thrombopoietin and interleukin-6 levels in Henoch-Schonlein purpura. J Microbiol Immunol Infect. 2006; 39(6): 476-82[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader