Iranian Journal of Pediatrics

Published by: Kowsar
Uncorrected Proof scheduled for 29 (4)

Bronchoalveolar Lavage to Treat Neonatal Meconium Aspiration Syndrome Under Monitoring of Lung Ultrasound Based on a Prospective Case Series Study

Ru-Xin Qiu 1 , Xiao-Ling Ren 1 , Jing Liu 1 , 2 , * , Jian-Jun Li 1 , Yue-Qiao Gao 1 and Rong-Ming Xia 1
Authors Information
1 Department of Neonatology and NICU, Beijing Chaoyang District Maternal and Child Healthcare Hospital, Beijing, China
2 Department of Neonatology and NICU of Bayi Children's Hospital, The Army General Hospital of the Chinese PLA, Beijing, China
Article information
  • Iranian Journal of Pediatrics: In Press (In Press); e90012
  • Published Online: August 6, 2019
  • Article Type: Research Article
  • Received: January 29, 2019
  • Revised: April 18, 2019
  • Accepted: May 25, 2019
  • DOI: 10.5812/ijp.90012

How to Cite: Qiu R, Ren X, Liu J , Li J, Gao Y, et al. Bronchoalveolar Lavage to Treat Neonatal Meconium Aspiration Syndrome Under Monitoring of Lung Ultrasound Based on a Prospective Case Series Study, Iran J Pediatr. Online ahead of Print ; In Press(In Press):e90012. doi: 10.5812/ijp.90012.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. van Ierland Y, de Beaufort AJ. Why does meconium cause meconium aspiration syndrome? Current concepts of MAS pathophysiology. Early Hum Dev. 2009;85(10):617-20. doi: 10.1016/j.earlhumdev.2009.09.009. [PubMed: 19833459].
  • 2. Parker TA, Kinsella JP. Meconium aspiration syndrome. In: Gleason CA, Devaskar SU, editors. Avery's diseases of the newborn. 9th ed. Philadelphia, USA: Elsevier Saunders; 2012. p. 652-3.
  • 3. Dargaville PA, Copnell B, New Zealand Neonatal Network ; Australian. The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics. 2006;117(5):1712-21. doi: 10.1542/peds.2005-2215. [PubMed: 16651329].
  • 4. Xu H, Hofmeyr J, Roy C, Fraser W. Intrapartum amnioinfusion for meconium-stained amniotic fluid: A systematic review of randomised controlled trials. BJOG. 2007;114(4):383-90. doi: 10.1111/j.1471-0528.2007.01262.x. [PubMed: 17378813].
  • 5. Liu J, Cao HY, Fu W. Lung ultrasonography to diagnose meconium aspiration syndrome of the newborn. J Int Med Res. 2016;44(6):1534-42. doi: 10.1177/0300060516663954. [PubMed: 27807253]. [PubMed Central: PMC5536754].
  • 6. Liu J, Cao HY, Chen SW. Lung ultrasonography for the diagnosis of meconium aspiration syndrome of the newborn infants. Chin J Appl Clin Pediatr. 2016;31(16):1227-30.
  • 7. Liu J, Ren XL, Fu W, Liu Y, Xia RM. Bronchoalveolar lavage for the treatment of neonatal pulmonary atelectasis under lung ultrasound monitoring. J Matern Fetal Neonatal Med. 2017;30(19):2362-6. doi: 10.1080/14767058.2016.1248935. [PubMed: 27756159].
  • 8. Liu J, Ren XL, Li JJ. POC-LUS guiding pleural puncture drainage to treat neonatal pulmonary atelectasis caused by congenital massive effusion. J Matern Fetal Neonatal Med. 2018:1-3. doi: 10.1080/14767058.2018.1526921. [PubMed: 30244617].
  • 9. Piastra M, Yousef N, Brat R, Manzoni P, Mokhtari M, De Luca D. Lung ultrasound findings in meconium aspiration syndrome. Early Hum Dev. 2014;90 Suppl 2:S41-3. doi: 10.1016/S0378-3782(14)50011-4. [PubMed: 25220126].
  • 10. Abu-Shaweesh JM. Meconium aspiration syndrome. In: Martin RJ, Fanaroff AA, Walsh MC, editors. Fanaroff and Martin's neonatal-perinatal medicine. 9th ed. Louis, USA: Elsevier Mosby; 2011. p. 1157-60.
  • 11. Ping Kirk AH, Sng QW, Zhang LQ, Ming Wong JJ, Puthucheary J, Lee JH. Characteristics and outcomes of long-stay patients in the pediatric intensive care unit. J Pediatr Intensive Care. 2018;7(1):1-6. doi: 10.1055/s-0037-1601337. [PubMed: 31073460]. [PubMed Central: PMC6260322].
  • 12. Liu J, Xia RM, Ren XL, Li JJ. The new application of point-of-care lung ultrasound in guiding or assisting neonatal severe lung disease treatment based on a case series. J Matern Fetal Neonatal Med. 2019:1-9. doi: 10.1080/14767058.2019.1590332. [PubMed: 30835592].
  • 13. Choi HJ, Hahn S, Lee J, Park BJ, Lee SM, Kim HS, et al. Surfactant lavage therapy for meconium aspiration syndrome: A systematic review and meta-analysis. Neonatology. 2012;101(3):183-91. doi: 10.1159/000329822. [PubMed: 22067375].
  • 14. Colman N, Figueroa J, McCracken C, Hebbar K. Simulation-based team training improves team performance among pediatric intensive care unit staff. J Pediatr Intensive Care. 2019;8(2):83-91. doi: 10.1055/s-0038-1676469. [PubMed: 31093460]. [PubMed Central: PMC6517053].
  • 15. Liu J, Copetti R, Sorantin E, Lovrenski J, Rodriguez-Fanjul J, Kurepa D, et al. Protocol and guidelines for point-of-care lung ultrasound in diagnosing neonatal pulmonary diseases based on international expert consensus. J Vis Exp. 2019;6(145). e58990. doi: 10.3791/58990. [PubMed: 30907892].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments