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Treatment of Children with Advanced-Stage Lymphoblastic Lymphoma with Pegaspargase

AUTHORS

Jian Chang 1 , * , Zhang Yu-tong 2 , FENG Li-hua 3 , Zhong Xiao-dan 4 , Wang Li-zhe 5

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How to Cite: Chang J , Yu-tong Z, Li-hua F, Xiao-dan Z , Li-zhe W. Treatment of Children with Advanced-Stage Lymphoblastic Lymphoma with Pegaspargase, Iran J Pediatr. 2014 ; 24(1):75-80.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 24 (1); 75-80
Published Online: January 26, 2014
Article Type: Research Article
Received: April 06, 2013
Accepted: December 08, 2013

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Abstract

Objective: To evaluate the feasibility of Pegaspargase instead of L-asparaginase to treat children with advanced-stage lymphoblastic lymphoma (LBL) on the Berlin-Frankfurt-Munster (BFM)-95 protocol. Methods: Fifty-four newly diagnosed patients with stage III or IV LBL and without any treatment were enrolled in this study. Pegaspargase took place of L-asparaginase in BFM-95. The complications and treatment responses of patients treated on the BFM-95 protocol and modified BFM-95 protocol were then evaluated respectively. Findings: For LBL patients treated with BFM-95 protocol or modified BFM-95 protocol, the complete response, event-free survival, overall survival were similar. Stage 4 myelosuppression was the most common complication in both groups. Besides that, among 31 patients receiving modified BFM-95 protocol, coagulation defects were the most common complication. In contrast, anaphylactic reaction was the most common complication in the other 23 patients receiving BFM-95 protocol. Conclusion: Modified BFM-95 protocol is available to children with advanced-stage LBL with an equal outcome and enhances its compliance and decreases the incidence of anaphylactic reaction, compared to BFM-95 protocol. Coagulation defects are the major complication and tolerable in modified one.

 

Keywords

Pegaspargase L-Asparaginase Lymphoblastic Lymphoma Chemotherapy

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