Iranian Journal of Pediatrics

Published by: Kowsar

Low Serum Mannose Binding Lectin (MBL) Levels and -221 YX Genotype of MBL2 Gene Are Susceptible to Neonatal Sepsis in the Chinese Han Population

Heng Xue 1 , 2 , Xiaoguang Xue 1 , Changyi Yang 3 , * , Qingquan Chen 2 , Ni Lin 2 , Yujun Lin 4 , Min Chen 2 , * , Dongdong Rao 1 and Huizi Lin 3
Authors Information
1 Department of Laboratory Medicine, Fujian Provincial Maternity and Children Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China
2 Department of Laboratory Medicine, Medical Technology and Engineering College, Fujian Medical University, Fuzhou, China
3 Department of Neonatology, Fujian Provincial Maternity and Children Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China
4 The fourth ward, Fuzhou Tuberculosis Prevention and Cure Hospital, Fuzhou, China
Corresponding Authors:
Article information
  • Iranian Journal of Pediatrics: June 2017, 27 (3); e9448
  • Published Online: February 8, 2017
  • Article Type: Research Article
  • Received: October 23, 2016
  • Revised: December 11, 2016
  • Accepted: January 13, 2017
  • DOI: 10.5812/ijp.9448

To Cite: Xue H, Xue X, Yang C, Chen Q, Lin N, et al. Low Serum Mannose Binding Lectin (MBL) Levels and -221 YX Genotype of MBL2 Gene Are Susceptible to Neonatal Sepsis in the Chinese Han Population, Iran J Pediatr. 2017 ; 27(3):e9448. doi: 10.5812/ijp.9448.

Copyright © 2017, Growth & Development Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Lawn JE, Cousens S, Zupan J, Lancet Neonatal Survival Steering T. 4 million neonatal deaths: when? Where? Why? Lancet. 2005; 365(9462): 891-900[DOI][PubMed]
  • 2. Adib M, Bakhshiani Z, Navaei F, Saheb Fosoul F, Fouladi S, Kazemzadeh H. Procalcitonin: a reliable marker for the diagnosis of neonatal sepsis. Iran J Basic Med Sci. 2012; 15(2): 777-82[PubMed]
  • 3. Krishnaveni P, Vanitha M, Pradeep G. Estimation of serum amyloid A protein in neonatal sepsis: a prospective study. Int J Med Sci Public Health. 2016; 5(8): 1665[DOI]
  • 4. Angeletti S, Battistoni F, Fioravanti M, Bernardini S, Dicuonzo G. Procalcitonin and mid-regional pro-adrenomedullin test combination in sepsis diagnosis. Clin Chem Lab Med. 2013; 51(5): 1059-67[DOI][PubMed]
  • 5. Zurek J, Vavrina M. Procalcitonin Biomarker Kinetics to Predict Multiorgan Dysfunction Syndrome in Children With Sepsis and Systemic Inflammatory Response Syndrome. Iran J Pediatr. 2015; 25(1)[DOI][PubMed]
  • 6. de Benedetti F, Auriti C, D'Urbano LE, Ronchetti MP, Rava L, Tozzi A, et al. Low serum levels of mannose binding lectin are a risk factor for neonatal sepsis. Pediatr Res. 2007; 61(3): 325-8[DOI][PubMed]
  • 7. Ozkan H, Koksal N, Cetinkaya M, Kilic S, Celebi S, Oral B, et al. Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia. J Perinatol. 2012; 32(3): 210-7[DOI][PubMed]
  • 8. Wahab Mohamed WA, Saeed MA. Mannose-binding lectin serum levels in neonatal sepsis and septic shock. J Matern Fetal Neonatal Med. 2012; 25(4): 411-4[DOI][PubMed]
  • 9. Giubergia V, Salim M, Fraga J, Castiglioni N, Sen L, Castanos C, et al. Post-infectious bronchiolitis obliterans and mannose-binding lectin insufficiency in Argentinean children. Respirology. 2015; 20(6): 982-6[DOI][PubMed]
  • 10. Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche JD, et al. Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort. Clin Infect Dis. 2015; 61(5): 695-703[DOI][PubMed]
  • 11. Zhang AQ, Yue CL, Pan W, Gao JW, Zeng L, Gu W, et al. Mannose-binding lectin polymorphisms and the risk of sepsis: evidence from a meta-analysis. Epidemiol Infect. 2014; 142(10): 2195-206[DOI][PubMed]
  • 12. Frakking FN, Brouwer N, van Eijkelenburg NK, Merkus MP, Kuijpers TW, Offringa M, et al. Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis. Clin Exp Immunol. 2007; 150(2): 255-62[DOI][PubMed]
  • 13. Ozdemir O, Dinleyici EC, Tekin N, Colak O, Aksit MA. Low-mannose-binding lectin levels in susceptibility to neonatal sepsis in preterm neonates with fetal inflammatory response syndrome. J Matern Fetal Neonatal Med. 2010; 23(9): 1009-13[DOI][PubMed]
  • 14. Gao DN, Zhang Y, Ren YB, Kang J, Jiang L, Feng Z, et al. Relationship of serum mannose-binding lectin levels with the development of sepsis: a meta-analysis. Inflammation. 2015; 38(1): 338-47[DOI][PubMed]
  • 15. Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, et al. Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis. 2012; 12(12): 919-24[DOI][PubMed]
  • 16. Chen QQ, Dong F, Chen M, Gao F, Liu QC. Arg194–Arg399 haplotype of XRCC1 gene is susceptible to lung cancer in the Han population. Eur J Inflam. 2016; 14(1): 27-33
  • 17. Chen Q, Xue H, Chen M, Gao F, Xu J, Liu Q, et al. High serum trypsin levels and the -409 T/T genotype of PRSS1 gene are susceptible to neonatal sepsis. Inflammation. 2014; 37(5): 1751-6[DOI][PubMed]
  • 18. Zinyama-Gutsire RB, Chasela C, Madsen HO, Rusakaniko S, Kallestrup P, Christiansen M, et al. Role of mannose-binding lectin deficiency in HIV-1 and schistosoma infections in a rural adult population in Zimbabwe. PLoS One. 2015; 10(4)[DOI][PubMed]
  • 19. Das BK, Panda AK. MBL-2 polymorphisms (codon 54 and Y-221X) and low MBL levels are associated with susceptibility to multi organ dysfunction in P. falciparum malaria in Odisha, India. Front Microbiol. 2015; 6: 778[DOI][PubMed]
  • 20. Prencipe G, Azzari C, Moriondo M, Devito R, Inglese R, Pezzullo M, et al. Association between mannose-binding lectin gene polymorphisms and necrotizing enterocolitis in preterm infants. J Pediatr Gastroenterol Nutr. 2012; 55(2): 160-5[DOI][PubMed]
  • 21. Auriti C, Prencipe G, Inglese R, Azzari C, Ronchetti MP, Tozzi A, et al. Role of mannose-binding lectin in nosocomial sepsis in critically ill neonates. Hum Immunol. 2010; 71(11): 1084-8[DOI][PubMed]
  • 22. Liu L, Ning B. The role of MBL2 gene polymorphism in sepsis incidence. Int J Clin Exp Pathol. 2015; 8(11): 15123-7[PubMed]
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