Diagnostic Value of Provocative Test by Insulin Combined with Clonidine for Growth Hormone Deficiency in Children

AUTHORS

Cheng Guo 1 , Li Chen 2 , *

How to Cite: Guo C, Chen L. Diagnostic Value of Provocative Test by Insulin Combined with Clonidine for Growth Hormone Deficiency in Children, Iran J Pediatr. 2013 ; 23(3):315-320.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 23 (3); 315-320
Published Online: May 05, 2013
Article Type: Research Article
Received: March 14, 2012
Accepted: April 06, 2013

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Abstract

Objective: To evaluate the diagnostic value of provocative test by insulin combined with clonidine for growth hormone deficiency (GHD) during childhood
Methods: Eighty children underwent a provocative test with insulin(0.075U/Kg, intravenous) combined with clonidine (4μg/kg, orally). Among them, 40 children underwent clonidine provocative test, 40 children underwent insulin tolerance test (ITT) in another day.
Findings: The specificity of ITT+clonidine test (74%, 88%) was remarkably higher than that of ITT (48%) or clonidine test (65%). ITT+clonidine test had a better accuracy (75%, 85%) than that of ITT (63%) or clonidine test (73%)
Conclusion: We conclude that the combined clonidine+insulin test is a feasible, reliable, convenient, time saving, and safe tool for evaluation of the growth hormone (GH) axes than the clonidine test or ITT.

 

Keywords

Clonidine Insulin Growth Hormone Growth Hormone Deficiency Short Stature

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