The Relationship of Aluminium and Silver to Neural Tube Defects; a Case Control

AUTHORS

Ruth Martínez-Cruz 1 , Pedro Hernández Cruz 1 , Margarito Martínez Cruz 2 , Flor de María Harp-Iturribarria 3 , Elvira Sivet-Chiñas 4 , María de Jesús Ramírez-Altamirano 5 , Patricia Fenton-Navarro 4 , Eduardo Pérez-Campos 6 , *

1 Center of Medical and Biological Research, Benito Juarez University of Oaxaca (UABJO), & Multidisciplinary Research Center. UNAM-UABJO, Oaxaca, Mexico

2 Department of Biochemistry and Immunology, Technological Institute of Oaxaca, Mexico

3 Mexican Geological Center, Oaxaca Unit, Mexico

4 Department of Genetics, General Hospital “Aurelio Valdivieso”, Mexico

5 Chemistry Department, Technological Institute of Oaxaca, Mexico

6 Department of Biochemistry and Immunology, Technological Institute of Oaxaca, & Multidisciplinary Research Center. UNAM-UABJO, Oaxaca, Mexico

How to Cite: Martínez-Cruz R, Hernández Cruz P, Martínez Cruz M, Harp-Iturribarria F D M, Sivet-Chiñas E, et al. The Relationship of Aluminium and Silver to Neural Tube Defects; a Case Control, Iran J Pediatr. 2015 ; 22(3):369-374.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 22 (3); 369-374
Published Online: September 30, 2012
Article Type: Research Article
Received: May 18, 2011
Accepted: March 15, 2012

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Abstract

Objective: The purpose of this study was to identify the relationship of neurotoxic inorganic elements in the hair of patients with the diagnosis of Neural Tube Defects. Our initial hypothesis was that neurotoxic inorganic elements were associated with Neural Tube Defects.
Methods: Twenty-three samples of hair from newborns were obtained from the General Hospital, “Aurelio Valdivieso” in the city of Oaxaca, Mexico. The study group included 8 newborn infants with neural tube pathology. The control group was composed of 15 newborns without this pathology. The presence of inorganic elements in the hair samples was determined by inductively-coupled plasma spectroscopy (spectroscopic emission of the plasma).
Findings: The population of newborns with Neural Tube Defects showed significantly higher values of the following elements than the control group: Aluminium, Neural Tube Defects 152.77±51.06 µg/g, control group 76.24±27.89 µg/g; Silver, Neural Tube Defects 1.45±0.76, control group 0.25±0.53 µg/g; Potassium, Neural Tube Defects 553.87±77.91 µg/g, control group 341.13±205.90 µg/g. Association was found at 75 percentile between aluminium plus silver, aluminium plus potassium, silver plus potassium, and potassium plus sodium.
Conclusion: In the hair of newborns with Neural Tube Defects, the following metals were increased: aluminium, silver. Given the neurotoxicity of the same, and association of Neural Tube Defects with aluminum and silver, one may infer that they may be participating as factors in the development of Neural Tube Defects.

 

Keywords

Aluminium Silver Hair Newborns Neural Tube Defects

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