Interstitial Lung Disease in a Patient with Chronic Granulomatous Disease

AUTHORS

Nima Rezaei 1 , Sara Kashef 2 , Mozhgan Moghtaderi 2 , *

1 Research Group for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran & Molecular Immunology Research Center; and Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran

2 Allergy Research Center, Shiraz University of Medical Sciences, Shiraz & Department of Pediatrics, Division of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran

How to Cite: Rezaei N, Kashef S, Moghtaderi M. Interstitial Lung Disease in a Patient with Chronic Granulomatous Disease, Iran J Pediatr. 2016 ; 22(1):129-132.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 22 (1); 129-132
Published Online: March 31, 2012
Article Type: Case Report
Received: October 27, 2010
Accepted: March 03, 2011

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Abstract

Background: Chronic granulomatous disease (CGD) is an inherited phagocytes defect, characterized by defects of NADPH-oxidase and inability of bacterial killing, which leads to recurrent life-threatening infections. Respiratory problems, which are the major cause of morbidity in CGD, usually result from recurrent severe infections; however, vigorous inflammatory response could also cause respiratory diseases.
Case Presentation: Herein, an 11 year-old patient with CGD is presented who suffered from chronic cough and dyspnea for 7 years. Considering the results of chest X-ray, high-resolution computed tomography, and pulmonary function test, the diagnosis of interstitial lung disease was made.
Conclusion: Early recognition of manifestations associated with CGD and appropriate treatment could prevent further complications and reduce morbidity and mortality in this group of patients.

 

Keywords

Chronic Granulomatous Disease Interstitial Lung Disease Immunodeficiency

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