Risk Factors and Predictors of Mortality in Critically ill Children with Extensively-Drug Resistant Acinetobacter baumannii Infection in a Pediatric Intensive Care Unit

AUTHORS

Kapil Kapoor 1 , * , Sumidha Jain 2 , Mamta Jajoo 3 , Swati Dublish 4 , Vikas Dabas 5 , Vikas Manchanda 6

1

2

3

4

5

6

How to Cite: Kapoor K, Jain S , Jajoo M , Dublish S , Dabas V , et al. Risk Factors and Predictors of Mortality in Critically ill Children with Extensively-Drug Resistant Acinetobacter baumannii Infection in a Pediatric Intensive Care Unit, Iran J Pediatr. 2014 ; 24(5):569-574.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 24 (5); 569-574
Published Online: September 11, 2014
Article Type: Research Article
Received: October 30, 2013
Accepted: May 05, 2014

Crossmark

CHEKING

READ FULL TEXT
Abstract

 

Objective: Acinetobacter baumannii is an important emerging cause for extensively-drug resistant (XDR) hospital associated infections (HAIs) in pediatric intensive care units (PICU). The study was done to evaluate the risk factors, outcome, antibiotic sensitivity pattern, and predictors of mortality in critically ill children with XDR A. baumannii infection. Methods: Retrospective case control study, done in the PICU of a tertiary care pediatric hospital of India from April 2010 to March 2012. Findings: Eighty-five children who developed XDR A. baumannii infection matched to 170 controls. Majority (76%) of the organisms were isolated from endotracheal lavage. The mortality rate was 28.2% (24/85). The factors found to be significantly associated with A. baumannii infection were prior use of broad-spectrum antibiotics, major surgeries done, prolonged PICU stay, use of central venous catheters, and mechanical ventilation. The predictors of mortality associated with A. baumannii infection were acute kidney injury, presence of septic shock, and disseminated intravascular coagulopathy. Colistin found to be the single most effective drug against XDR A. baumannii infection. Conclusion: XDR A. baumannii infections are associated with high morbidity and mortality in critically ill children. Early diagnosis and treatment are crucial. Implementation of infection control practices and rational use of antibiotics are required to control such infections.

 

Keywords

Acinetobacter Baumannii Extensively-Drug Resistant Hospital Associated Infection Children

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

References

  • 1.

    Reference are available on the PDF.

  • COMMENTS

    LEAVE A COMMENT HERE: