Is Supplementation Efficacious in Maintaining Adequate Plasma Levels of Vitamin A and E for Thalassemic Patients Undergoing Hematopoietic Stem Cell Transplantation? A Cross-Sectional Study

AUTHORS

Ava Mansouri 1 , * , Mannan Hajimahmoodi 2 , Molouk Hadjibabaie 3 , Amir-Ali Hamidieh 4 , Alireza Ahmadvand 5 , Sahebeh Kazempanah 6 , Naficeh Sadeghi 7 , Ardeshir Ghavamzadeh 8

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How to Cite: Mansouri A, Hajimahmoodi M, Hadjibabaie M, Hamidieh A, Ahmadvand A , et al. Is Supplementation Efficacious in Maintaining Adequate Plasma Levels of Vitamin A and E for Thalassemic Patients Undergoing Hematopoietic Stem Cell Transplantation? A Cross-Sectional Study, Iran J Pediatr. 2014 ; 24(1):35-41.

ARTICLE INFORMATION

Iranian Journal of Pediatrics: 24 (1); 35-41
Published Online: January 02, 2014
Article Type: Research Article
Received: February 27, 2013
Accepted: November 18, 2013

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Abstract

Objective: Thalassemia along with hematopoietic stem cell transplantation (HSCT) can lead to major oxidative stress. Vitamins A and E are antioxidants which protect membrane from lipid peroxidation. We sought to determine for the first time, whether vitamins A and E supplementation is efficacious in maintaining or increasing plasma level of these vitamins in thalassemic children undergoing HSCT. Methods: A cross-sectional study was performed on 50 children with β-thalassemia major hospitalized for HSCT. Patients took a daily multivitamin. Plasma vitamins A and E levels were measured at four different times: on admission, HSCT day (day 0), day 7 and day 14 after HSCT. Findings: Plasma vitamin A and E were abnormal on admission in most patients (62.0% and 60.0% respectively). Ratio of patient with normal to abnormal plasma level of the vitamins improved from baseline to a peak on day 7 then deteriorated afterward until day 14. There was an increasingly positive correlation between daily oral intake and plasma vitamin A at different times, but plasma vitamin E showed inverse correlation at first which tended towards no correlation subsequently. In multivariate analysis, supplementation significantly changed plasma level of vitamin A at different measurement time (P=0.001) within study subjects. But, plasma level of vitamin E showed no significant difference (P=0.2). Conclusion: Our findings suggest that oral supplementation could have beneficial effects due to increasing plasma vitamin A level and preventing plasma vitamin E depletion.

 

Keywords

Thalassemia Hematopoietic Stem Cell Transplantation Vitamin A Vitamin E Dietary Supplements

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